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BMC Medical Research Methodology

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  1. Content type: Research article

    Parametric distributions based on individual patient data can be used to represent both stochastic and parameter uncertainty. Although general guidance is available on how parameter uncertainty should be accou...

    Authors: Koen Degeling, Maarten J. IJzerman, Miriam Koopman and Hendrik Koffijberg

    Citation: BMC Medical Research Methodology 2017 17:170

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  2. Content type: Research article

    Recruitment rates of older people in epidemiological studies, although relatively higher than in clinical trials, have declined in recent years. This study aimed to explore motivating factors and concerns amon...

    Authors: Alicja M. Baczynska, Sarah C. Shaw, Harnish P. Patel, Avan A. Sayer and Helen C. Roberts

    Citation: BMC Medical Research Methodology 2017 17:167

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  3. Content type: Research article

    Diagnostic tests are performed in a subset of the population who are at higher risk, resulting in undiagnosed cases among those who do not receive the test. This poses a challenge for estimating the prevalence...

    Authors: Nanhua Zhang, Si Cheng, Lilliam Ambroggio, Todd A. Florin and Maurizio Macaluso

    Citation: BMC Medical Research Methodology 2017 17:168

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  4. Content type: Research article

    Summary of findings tables in systematic reviews are highly informative but require epidemiological training to be interpreted correctly. The usage of fishbone diagrams as graphical displays could offer resear...

    Authors: Gerald Gartlehner, Marie-Therese Schultes, Viktoria Titscher, Laura C. Morgan, Georgiy V. Bobashev, Peyton Williams and Suzanne L. West

    Citation: BMC Medical Research Methodology 2017 17:169

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  5. Content type: Research article

    The variable “small for gestational age,” frequently defined as birth weight below the 10th percentile in a gestational age and sex-normalized population, is nowadays generally perceived as a more adequate mea...

    Authors: Geneviève Lefebvre and Mariia Samoilenko

    Citation: BMC Medical Research Methodology 2017 17:165

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  6. Content type: Research article

    The bias caused by drop-out is an important factor in large population-based epidemiological studies. Many studies account for it by weighting their longitudinal data, but to date there is no detailed final ap...

    Authors: Steffen C. E. Schmidt and Alexander Woll

    Citation: BMC Medical Research Methodology 2017 17:164

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  7. Content type: Research article

    Clinical studies in children are necessary yet conducting multiple visits at study centers remains challenging. The success of “care-at-home” initiatives and remote clinical trials suggests their potential to ...

    Authors: Belinda von Niederhäusern, Ramon Saccilotto, Sabine Schädelin, Victoria Ziesenitz, Pascal Benkert, Marie-Luise Decker, Anya Hammann, Julia Bielicki, Marc Pfister and Christiane Pauli-Magnus

    Citation: BMC Medical Research Methodology 2017 17:163

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  8. Content type: Research article

    As implementation science advances, the number of interventions to promote the translation of evidence into healthcare, health systems, or health policy is growing. Accordingly, classification schemes for thes...

    Authors: Susan E. Slaughter, Gabrielle L. Zimmermann, Megan Nuspl, Heather M. Hanson, Lauren Albrecht, Rosmin Esmail, Khara Sauro, Amanda S. Newton, Maoliosa Donald, Michele P. Dyson, Denise Thomson and Lisa Hartling

    Citation: BMC Medical Research Methodology 2017 17:161

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  9. Content type: Research article

    Missing data may seriously compromise inferences from randomised clinical trials, especially if missing data are not handled appropriately. The potential bias due to missing data depends on the mechanism causi...

    Authors: Janus Christian Jakobsen, Christian Gluud, Jørn Wetterslev and Per Winkel

    Citation: BMC Medical Research Methodology 2017 17:162

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  10. Content type: Research article

    The Marginal Structural Cox Model (Cox-MSM), an alternative approach to handle time-dependent confounder, was introduced for survival analysis and applied to estimate the joint causal effect of two time-depend...

    Authors: Clovis Lusivika-Nzinga, Hana Selinger-Leneman, Sophie Grabar, Dominique Costagliola and Fabrice Carrat

    Citation: BMC Medical Research Methodology 2017 17:160

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  11. Content type: Technical advance

    Randomization is considered to be a key feature to protect against bias in randomized clinical trials. Randomization induces comparability with respect to known and unknown covariates, mitigates selection bias...

    Authors: Ralf-Dieter Hilgers, Diane Uschner, William F. Rosenberger and Nicole Heussen

    Citation: BMC Medical Research Methodology 2017 17:159

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  12. Content type: Research article

    In healthcare research, outcomes with skewed probability distributions are common. Sample size calculations for such outcomes are typically based on estimates on a transformed scale (e.g. log) which may someti...

    Authors: Aidan G. O’Keeffe, Gareth Ambler and Julie A. Barber

    Citation: BMC Medical Research Methodology 2017 17:157

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  13. Content type: Research article

    The Alcohol Use Disorders Identification Test (AUDIT) is a commonly used scale to measure severity of alcohol consumption that contains an item asking if anyone has expressed concern about your drinking or sug...

    Authors: John A. Cunningham, Alexandra Godinho, Vladyslav Kushnir and Nicolas Bertholet

    Citation: BMC Medical Research Methodology 2017 17:158

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  14. Content type: Research article

    The follow-up rate, a standard index of the completeness of follow-up, is important for assessing the validity of a cohort study. A common method for estimating the follow-up rate, the “Percentage Method”, def...

    Authors: Xiaonan Xue, Ilir Agalliu, Mimi Y. Kim, Tao Wang, Juan Lin, Reza Ghavamian and Howard D. Strickler

    Citation: BMC Medical Research Methodology 2017 17:155

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  15. Content type: Research article

    Regulations, study design complexity and amounts of collected and shared data in clinical trials render efficient data handling procedures inevitable. Recent research suggests that electronic data capture can ...

    Authors: Robert Fleischmann, Anne-Marie Decker, Antje Kraft, Knut Mai and Sein Schmidt

    Citation: BMC Medical Research Methodology 2017 17:153

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  16. Content type: Research article

    Exploratory preclinical, as well as clinical trials, may involve a small number of patients, making it difficult to calculate and analyze the pharmacokinetic (PK) parameters, especially if the PK parameters sh...

    Authors: Sudeep Pradhan, Byungjeong Song, Jaeyeon Lee, Jung-woo Chae, Kyung Im Kim, Hyun-moon Back, Nayoung Han, Kwang-il Kwon and Hwi-yeol Yun

    Citation: BMC Medical Research Methodology 2017 17:154

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  17. Content type: Research article

    Mechanical Turk (MTurk) is an online portal operated by Amazon where ‘requesters’ (individuals or businesses) can submit jobs for ‘workers.’ MTurk is used extensively by academics as a quick and cheap means of...

    Authors: John A. Cunningham, Alexandra Godinho and Vladyslav Kushnir

    Citation: BMC Medical Research Methodology 2017 17:156

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  18. Content type: Research article

    Our objective was to assess the frequency of data extraction errors and its potential impact on results in systematic reviews. Furthermore, we evaluated the effect of different extraction methods, reviewer cha...

    Authors: Tim Mathes, Pauline Klaßen and Dawid Pieper

    Citation: BMC Medical Research Methodology 2017 17:152

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  19. Content type: Research article

    An up-to-date systematic review is important for researchers to decide whether to embark on new research or continue supporting ongoing studies. The aim of this study is to examine the time taken between the l...

    Authors: Wilson W. S. Tam, Kenneth K. H. Lo, Parames Khalechelvam, Joey Seah and Shawn Y. S. Goh

    Citation: BMC Medical Research Methodology 2017 17:151

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  20. Content type: Research article

    There are detailed reviews about different recruitment strategies, but not with regard to differences between recruitment of hospital-based versus office-based physicians. Within this study, the two different ...

    Authors: S. R. Zeissig, V. Weyer-Elberich, K. Emrich, H. Binder, S. Fischbeck, B. H. Imruck, P. Friedrich-Mai, M. E. Beutel and M. Blettner

    Citation: BMC Medical Research Methodology 2017 17:150

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  21. Content type: Research article

    It is important to quantify the dose response for a drug in phase 2a clinical trials so the optimal doses can then be selected for subsequent late phase trials. In a phase 2a clinical trial of new lead drug be...

    Authors: Feng Liu, Stephen J. Walters and Steven A. Julious

    Citation: BMC Medical Research Methodology 2017 17:149

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  22. Content type: Research Article

    The use of health-related quality of life (HRQoL) as an endpoint in cancer clinical trials is growing rapidly. Hence, research into the statistical approaches used to analyze HRQoL data is of major importance,...

    Authors: Antoine Barbieri, Jean Peyhardi, Thierry Conroy, Sophie Gourgou, Christian Lavergne and Caroline Mollevi

    Citation: BMC Medical Research Methodology 2017 17:148

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  23. Content type: Research article

    It is challenging for current statistical models to predict clinical progression of Parkinson’s disease (PD) because of the involvement of multi-domains and longitudinal data.

    Authors: Ming Wang, Zheng Li, Eun Young Lee, Mechelle M. Lewis, Lijun Zhang, Nicholas W. Sterling, Daymond Wagner, Paul Eslinger, Guangwei Du and Xuemei Huang

    Citation: BMC Medical Research Methodology 2017 17:147

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  24. Content type: Research article

    Several statistical approaches have been proposed to assess and correct for exposure measurement error. We aimed to provide a critical overview of the most common approaches used in nutritional epidemiology.

    Authors: Derrick A. Bennett, Denise Landry, Julian Little and Cosetta Minelli

    Citation: BMC Medical Research Methodology 2017 17:146

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