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  1. Observational studies are increasingly being used to provide supplementary evidence in addition to Randomized Control Trials (RCTs) because they provide a scale and diversity of participants and outcomes that ...

    Authors: Chinmay Belthangady, Will Stedden and Beau Norgeot

    Citation: BMC Medical Research Methodology 2021 21:190

    Content type: Research

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  2. Single group data present unique challenges for synthesises of evidence. Proportional meta-analysis is becoming an increasingly common technique employed for the synthesis of single group data. Proportional me...

    Authors: Timothy Hugh Barker, Celina Borges Migliavaca, Cinara Stein, Verônica Colpani, Maicon Falavigna, Edoardo Aromataris and Zachary Munn

    Citation: BMC Medical Research Methodology 2021 21:189

    Content type: Commentary

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  3. Patient-centered care is an essential component of health care quality. To achieve patient-centered care, health care authorities should have a clear definition and an applicable tool to measure the extent of ...

    Authors: Hana Hasan Webair, Tengku Alina Tengku Ismail, Shaiful Bahari Ismail, Azza Jameel Khaffaji, Nik Hazlina Nik Hussain, Azidah Abdul Kadir, Rosediani Muhamad, Fatin Aina Abu Bakar, Nur Raihan Ismail and Nagwa Badri

    Citation: BMC Medical Research Methodology 2021 21:188

    Content type: Research

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  4. Fundamental to the success of clinical research that involves human participants is the quality of the data that is generated. To ensure data quality, clinical trials must comply with the Good Clinical Practic...

    Authors: Lauren Houston, Ping Yu, Allison Martin and Yasmine Probst

    Citation: BMC Medical Research Methodology 2021 21:187

    Content type: Research

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  5. The emergence of antimicrobial resistance across populations is a global threat to public health. Surveillance programs often monitor human and animal populations to evaluate trends of emergence in these popul...

    Authors: Min Zhang, Chong Wang and Annette M. O’Connor

    Citation: BMC Medical Research Methodology 2021 21:186

    Content type: Research article

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  6. There are significant challenges associated with studies of people released from custodial settings, including loss to follow-up in the community. Interpretation of findings with consideration of differences b...

    Authors: Ashleigh Cara Stewart, Reece Cossar, Shelley Walker, Anna Lee Wilkinson, Brendan Quinn, Paul Dietze, Rebecca Winter, Amy Kirwan, Michael Curtis, James R. P. Ogloff, Stuart Kinner, Campbell Aitken, Tony Butler, Emma Woods and Mark Stoové

    Citation: BMC Medical Research Methodology 2021 21:185

    Content type: Research

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  7. Reviews of qualitative studies allow for deeper understanding of concepts and findings beyond the single qualitative studies. Concerns on study reporting quality led to the publication of the COREQ-guidelines ...

    Authors: Y. de Jong, E. M. van der Willik, J. Milders, C. G. N. Voorend, Rachael L. Morton, F. W. Dekker, Y. Meuleman and M. van Diepen

    Citation: BMC Medical Research Methodology 2021 21:184

    Content type: Research

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  8. Systematic and scoping literature searches are increasingly resource intensive. We present the results of a scoping review which combines the use of a novel artificial-intelligence-(AI)-assisted Medline search...

    Authors: Jane Whelan, Mohammad Ghoniem, Nicolas Médoc, Mike Apicella and Ekkehard Beck

    Citation: BMC Medical Research Methodology 2021 21:183

    Content type: Research

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  9. Healthcare decisions are ideally based on clinical trial results, published in study registries, as journal articles or summarized in secondary research articles. In this research project, we investigated the ...

    Authors: Anette Blümle, Katharina Wollmann, Karin Bischoff, Philipp Kapp, Szimonetta Lohner, Edris Nury, Kai Nitschke, Jasmin Zähringer, Gerta Rücker and Martin Schumacher

    Citation: BMC Medical Research Methodology 2021 21:182

    Content type: Research article

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  10. Interrupted time series (ITS) studies are frequently used to evaluate the effects of population-level interventions or exposures. However, examination of the performance of statistical methods for this design ...

    Authors: Simon L. Turner, Andrew B. Forbes, Amalia Karahalios, Monica Taljaard and Joanne E. McKenzie

    Citation: BMC Medical Research Methodology 2021 21:181

    Content type: Research

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  11. Since primary data collection can be time-consuming and expensive, surgical site infections (SSIs) could ideally be monitored using routinely collected administrative data. We derived and internally validated ...

    Authors: Yelena Petrosyan, Kednapa Thavorn, Glenys Smith, Malcolm Maclure, Roanne Preston, Carl van Walravan and Alan J. Forster

    Citation: BMC Medical Research Methodology 2021 21:179

    Content type: Research

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  12. Variations in clinical practice contribute to negative outcomes for children with cancer. Research in this area is imperative to standardise practice, yet such research is challenging to undertake, and a signi...

    Authors: Natalie Bradford, Christine Cashion, Paula Condon, Shelley Rumble and Alison Bowers

    Citation: BMC Medical Research Methodology 2021 21:178

    Content type: Research

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  13. Non-proportional hazards are common with time-to-event data but the majority of randomised clinical trials (RCTs) are designed and analysed using approaches which assume the treatment effect follows proportion...

    Authors: Kim Jachno, Stephane Heritier and Rory Wolfe

    Citation: BMC Medical Research Methodology 2021 21:177

    Content type: Research

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  14. Participation in epidemiologic studies has been declining over the last decades. In addition to postal invitations and phone calls, home visits can be conducted to increase participation. The aim of this study...

    Authors: Lilian Krist, Ahmed Bedir, Julia Fricke, Alexander Kluttig and Rafael Mikolajczyk

    Citation: BMC Medical Research Methodology 2021 21:176

    Content type: Research

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  15. Randomized controlled trials (RCT) are considered the ideal design for evaluating the efficacy of interventions. However, conducting a successful RCT has technological and logistical challenges. Defects in ran...

    Authors: Sina Kianersi, Maya Luetke, Christina Ludema, Alexander Valenzuela and Molly Rosenberg

    Citation: BMC Medical Research Methodology 2021 21:175

    Content type: Research article

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  16. The use of auxiliary variables with maximum likelihood parameter estimation for surveys that miss data by design is not a widespread approach, despite its documented improved efficiency over traditional approa...

    Authors: George Vamvakas, Courtenay Norbury and Andrew Pickles

    Citation: BMC Medical Research Methodology 2021 21:173

    Content type: Article

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  17. While web conferencing technologies are being widely used in communication and collaboration, their uptake in conducting research field work has been relatively slow. The benefits that these technologies offer...

    Authors: Kate Anderson, Alana Gall, Tamara Butler, Brian Arley, Kirsten Howard, Alan Cass and Gail Garvey

    Citation: BMC Medical Research Methodology 2021 21:172

    Content type: Research

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  18. Null hypothesis significance testing (NHST) is among the most frequently employed methods in the biomedical sciences. However, the problems of NHST and p-values have been discussed widely and various Bayesian alt...

    Authors: Riko Kelter

    Citation: BMC Medical Research Methodology 2021 21:171

    Content type: Research article

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  19. To model the progression of geographic atrophy (GA) in patients with age-related macular degeneration (AMD) by building a suitable statistical regression model for GA size measurements obtained from fundus aut...

    Authors: Charlotte Behning, Monika Fleckenstein, Maximilian Pfau, Christine Adrion, Lukas Goerdt, Moritz Lindner, Steffen Schmitz-Valckenberg, Frank G Holz and Matthias Schmid

    Citation: BMC Medical Research Methodology 2021 21:170

    Content type: Research

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  20. Machine learning tools that semi-automate data extraction may create efficiencies in systematic review production. We evaluated a machine learning and text mining tool’s ability to (a) automatically extract da...

    Authors: Allison Gates, Michelle Gates, Shannon Sim, Sarah A. Elliott, Jennifer Pillay and Lisa Hartling

    Citation: BMC Medical Research Methodology 2021 21:169

    Content type: Research

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  21. Randomization is the foundation of any clinical trial involving treatment comparison. It helps mitigate selection bias, promotes similarity of treatment groups with respect to important known and unknown confo...

    Authors: Vance W. Berger, Louis Joseph Bour, Kerstine Carter, Jonathan J. Chipman, Colin C. Everett, Nicole Heussen, Catherine Hewitt, Ralf-Dieter Hilgers, Yuqun Abigail Luo, Jone Renteria, Yevgen Ryeznik, Oleksandr Sverdlov and Diane Uschner

    Citation: BMC Medical Research Methodology 2021 21:168

    Content type: Research

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  22. Few definitive guidelines exist for rigorous large-scale prospective evaluation of nonrandomized programs and policies that require longitudinal primary data collection. In Veterans Affairs (VA) we identified ...

    Authors: Valerie A. Smith, Courtney Harold Van Houtven, Jennifer H. Lindquist and Susan N. Hastings

    Citation: BMC Medical Research Methodology 2021 21:167

    Content type: Research article

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  23. Knowledge regarding symptom clusters may inform targeted interventions. The current study investigated symptom clusters among cancer survivors, using machine learning techniques on a large data set.

    Authors: Koen I. Neijenhuijs, Carel F. W. Peeters, Henk van Weert, Pim Cuijpers and Irma Verdonck-de Leeuw

    Citation: BMC Medical Research Methodology 2021 21:166

    Content type: Research

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  24. A considerable proportion of SARS-CoV-2 transmission occurs from asymptomatic and pre-symptomatic cases. Therefore, different polymerase chain reaction (PCR)- or rapid antigen test (RAT)-based approaches are b...

    Authors: Ralf Krumkamp, Benno Kreuels, Veronika K. Jaeger, Jürgen May, Rafael Mikolajczyk and André Karch

    Citation: BMC Medical Research Methodology 2021 21:165

    Content type: Research article

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  25. An essential aspect of preventing further COVID-19 outbreaks and to learn for future pandemics is the evaluation of different political strategies, which aim at reducing transmission of and mortality due to CO...

    Authors: Maja von Cube, Jéan-Francois Timsit, Andreas Kammerlander and Martin Schumacher

    Citation: BMC Medical Research Methodology 2021 21:164

    Content type: Research

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  26. The COVID-19 pandemic is currently a severe challenge for healthcare workers, with a considerable impact on their mental health. In order to focus preventive and rehabilitation measures it’s fundamental to ide...

    Authors: A Fattori, F Cantù, A Comotti, V Tombola, E Colombo, C Nava, L Bordini, L Riboldi, M Bonzini and P Brambilla

    Citation: BMC Medical Research Methodology 2021 21:163

    Content type: Research

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  27. Although many studies have investigated agreement between survey and hospitalization data for disease prevalence, it is unknown whether exposure-chronic disease associations vary based on data collection metho...

    Authors: Howard E. Alper, Jennifer Brite, James E. Cone and Robert M. Brackbill

    Citation: BMC Medical Research Methodology 2021 21:162

    Content type: Research

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  28. Non-participation in cohort studies, if associated with both the exposure and occurrence of the event, can introduce bias in the estimates of interest. This study aims to identify factors associated with follo...

    Authors: Leila Cheraghi, Parisa Amiri, Golnaz Vahedi-Notash, Sara Jalali-Farahani, Davood Khalili and Fereidoun Azizi

    Citation: BMC Medical Research Methodology 2021 21:161

    Content type: Research

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  29. Data monitoring of clinical trials is a tool aimed at reducing the risks of random errors (e.g. clerical errors) and systematic errors, which include misinterpretation, misunderstandings, and fabrication. Trad...

    Authors: Markus Harboe Olsen, Mathias Lühr Hansen, Sanam Safi, Janus Christian Jakobsen, Gorm Greisen and Christian Gluud

    Citation: BMC Medical Research Methodology 2021 21:160

    Content type: Research

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  30. HIV prevention measures in sub-Saharan Africa are still short of attaining the UNAIDS 90–90-90 fast track targets set in 2014. Identifying predictors for HIV status may facilitate targeted screening interventi...

    Authors: Charles K. Mutai, Patrick E. McSharry, Innocent Ngaruye and Edouard Musabanganji

    Citation: BMC Medical Research Methodology 2021 21:159

    Content type: Research

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  31. Authors: Jan W. van der Scheer, Matthew Woodward, Akbar Ansari, Tim Draycott, Cathy Winter, Graham Martin, Karolina Kuberska, Natalie Richards, Ruth Kern and Mary Dixon-Woods

    Citation: BMC Medical Research Methodology 2021 21:156

    Content type: Correction

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    The original article was published in BMC Medical Research Methodology 2021 21:103

  32. Linking independent sources of data describing the same individuals enable innovative epidemiological and health studies but require a robust record linkage approach. We describe a hybrid record linkage proces...

    Authors: Yue Jiao, Fabienne Lesueur, Chloé-Agathe Azencott, Maïté Laurent, Noura Mebirouk, Lilian Laborde, Juana Beauvallet, Marie-Gabrielle Dondon, Séverine Eon-Marchais, Anthony Laugé, Catherine Noguès, Nadine Andrieu, Dominique Stoppa-Lyonnet and Sandrine M. Caputo

    Citation: BMC Medical Research Methodology 2021 21:155

    Content type: Research article

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  33. Collinearity is a common and problematic phenomenon in studies on public health. It leads to inflation in variance of estimator and reduces test power. This phenomenon can occur in any model. In this study, a ...

    Authors: Sanaz Khalili, Javad Faradmal, Hossein Mahjub, Babak Moeini and Khadijeh Ezzati-Rastegar

    Citation: BMC Medical Research Methodology 2021 21:154

    Content type: Research

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  34. The Iberoamerican Cochrane Network is currently developing an extensive project to identify Spanish-language journals that publish original clinical research in Spain and Latin America. The project is called B...

    Authors: Vivienne C. Bachelet, María S. Navarrete, Constanza Barrera-Riquelme, Víctor A. Carrasco, Matías Dallaserra, Rubén A. Díaz, Álvaro A. Ibarra, Francisca J. Lizana, Nicolás Meza-Ducaud, Macarena G. Saavedra, Camila Tapia-Davegno, Alonso F. Vergara and Julio Villanueva

    Citation: BMC Medical Research Methodology 2021 21:153

    Content type: Research

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  35. Cluster randomised trials (CRTs) are increasingly used to evaluate non-pharmacological interventions for improving child health. Although methodological challenges of CRTs are well documented, the characterist...

    Authors: Kitty Parker, Michael Nunns, ZhiMin Xiao, Tamsin Ford and Obioha C. Ukoumunne

    Citation: BMC Medical Research Methodology 2021 21:152

    Content type: Research

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  36. Converting electronic health record (EHR) entries to useful clinical inferences requires one to address the poor scalability of existing implementations of Generalized Linear Mixed Models (GLMM) for repeated m...

    Authors: Cristian G. Bologa, Vernon Shane Pankratz, Mark L. Unruh, Maria Eleni Roumelioti, Vallabh Shah, Saeed Kamran Shaffi, Soraya Arzhan, John Cook and Christos Argyropoulos

    Citation: BMC Medical Research Methodology 2021 21:151

    Content type: Technical advance

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  37. Initially, the Cochrane risk of bias (RoB) tool had a domain for “blinding of participants, personnel and outcome assessors”. In the 2011 tool, the assessment of blinding was split into two domains: blinding o...

    Authors: Ognjen Barcot, Matija Boric, Svjetlana Dosenovic and Livia Puljak

    Citation: BMC Medical Research Methodology 2021 21:149

    Content type: Research article

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  38. Google Trends (GT) is being used as an epidemiological tool to study coronavirus disease (COVID-19) by identifying keywords in search trends that are predictive for the COVID-19 epidemiological burden. However...

    Authors: Kenichiro Sato, Tatsuo Mano, Atsushi Iwata and Tatsushi Toda

    Citation: BMC Medical Research Methodology 2021 21:147

    Content type: Research

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  39. Already at hospital admission, clinicians require simple tools to identify hospitalized COVID-19 patients at high risk of mortality. Such tools can significantly improve resource allocation and patient managem...

    Authors: Hamid Reza Marateb, Maja von Cube, Ramin Sami, Shaghayegh Haghjooy Javanmard, Marjan Mansourian, Babak Amra, Forogh Soltaninejad, Mojgan Mortazavi, Peyman Adibi, Nilufar Khademi, Nastaran Sadat Hosseini, Arash Toghyani, Razieh Hassannejad, Miquel Angel Mañanas, Harald Binder and Martin Wolkewitz

    Citation: BMC Medical Research Methodology 2021 21:146

    Content type: Research article

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  40. A large multi-center survey was conducted to understand patients’ perspectives on biobank study participation with particular focus on racial and ethnic minorities. In order to enrich the study sample with rac...

    Authors: Aya A. Mitani, Nathaniel D. Mercaldo, Sebastien Haneuse and Jonathan S. Schildcrout

    Citation: BMC Medical Research Methodology 2021 21:145

    Content type: Research article

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  41. Case–control studies based on pharmaco-epidemiological databases typically use decision rules to determine exposure status from information on dates of prescription redemptions, although this induces misclassi...

    Authors: Henrik Støvring, Anton Pottegård and Jesper Hallas

    Citation: BMC Medical Research Methodology 2021 21:144

    Content type: Research article

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  42. Various interacting and interdependent components comprise complex interventions. These components create difficulty in assessing the true impact of interventions designed to improve patient-centered outcomes....

    Authors: Maricela Cruz, Marco A. Pinto-Orellana, Daniel L. Gillen and Hernando C. Ombao

    Citation: BMC Medical Research Methodology 2021 21:143

    Content type: Software

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  43. Standard practice for conducting systematic reviews (SRs) is time consuming and involves the study team screening hundreds or thousands of citations. As the volume of medical literature grows, the citation set...

    Authors: Katie O’Hearn, Cameron MacDonald, Anne Tsampalieros, Leo Kadota, Ryan Sandarage, Supun Kotteduwa Jayawarden, Michele Datko, John M. Reynolds, Thanh Bui, Shagufta Sultan, Margaret Sampson, Misty Pratt, Nick Barrowman, Nassr Nama, Matthew Page and James Dayre McNally

    Citation: BMC Medical Research Methodology 2021 21:142

    Content type: Research

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  44. Children are more vulnerable to adverse drug reactions (ADRs) due to complex changes in the body during the growth process and lack specific pharmacoepidemiologic studies. Causality and Avoidability assessment...

    Authors: Elisangela da Costa Lima, Thais de Barros Fernandes, Adair Freitas, Juliana Freire de Lima Sias, Marcelo Gerardin Poirot Land, Mariana Tschoepke Aires, Louise Bracken and Matthew Peak

    Citation: BMC Medical Research Methodology 2021 21:141

    Content type: Research

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