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  1. Although there are discussions regarding standards of the analysis of patient-reported outcomes and quality of life (QOL) in oncology clinical trials, that of QOL with death events is not within their scope. F...

    Authors: Kentaro Sakamaki and Takuya Kawahara
    Citation: BMC Medical Research Methodology 2022 22:259
  2. To describe the temporal trend of the number of new congenital heart disease (CHD) cases among newborns in Jinhua from 2019 to 2020 and explored an appropriate model to fit and forecast the tendency of CHD.

    Authors: Weize Xu, Zehua Shao, Hongliang Lou, Jianchuan Qi, Jihua Zhu, Die Li and Qiang Shu
    Citation: BMC Medical Research Methodology 2022 22:257
  3. Assessing the long term effects of many surgical interventions tested in pragmatic RCTs may require extended periods of participant follow-up to assess effectiveness and use patient-reported outcomes that requ...

    Authors: Nick R. Parsons, Nigel Stallard, Helen Parsons, Aminul Haque, Martin Underwood, James Mason, Iftekhar Khan, Matthew L. Costa, Damian R. Griffin, James Griffin, David J. Beard, Jonathan A. Cook, Loretta Davies, Jemma Hudson and Andrew Metcalfe
    Citation: BMC Medical Research Methodology 2022 22:256
  4. Qualitative longitudinal research (QLR) comprises qualitative studies, with repeated data collection, that focus on the temporality (e.g., time and change) of a phenomenon. The use of QLR is increasing in heal...

    Authors: Åsa Audulv, Elisabeth O. C. Hall, Åsa Kneck, Thomas Westergren, Liv Fegran, Mona Kyndi Pedersen, Hanne Aagaard, Kristianna Lund Dam and Mette Spliid Ludvigsen
    Citation: BMC Medical Research Methodology 2022 22:255
  5. By substituting the general ‘susceptibility factor’ concept for the conventional ‘gene’ concept in the case-only approach for gene-environment interaction, the case-only approach can also be used in environmen...

    Authors: Jinyoung Moon and Hwan-Cheol Kim
    Citation: BMC Medical Research Methodology 2022 22:254
  6. The Symptom Checklist (SCL) developed by the Health Behaviour in School-aged Children (HBSC) study is a non-clinical measure of psychosomatic complaints (e.g., headache and feeling low) that has been used in n...

    Authors: Andreas Heinz, Philipp E. Sischka, Carolina Catunda, Alina Cosma, Irene García-Moya, Nelli Lyyra, Anne Kaman, Ulrike Ravens-Sieberer and William Pickett
    Citation: BMC Medical Research Methodology 2022 22:253
  7. Men are often viewed as a difficult group to recruit for psychological research, including in psycho-oncology. Whilst research has demonstrated the effectiveness of small monetary incentives for encouraging re...

    Authors: Megan McIntosh, Melissa J. Opozda, Michael O’Callaghan, Andrew D. Vincent, Daniel A. Galvão and Camille E. Short
    Citation: BMC Medical Research Methodology 2022 22:252
  8. In the context of the COVID-19 pandemic, social science research has required recruiting many prospective participants. Many researchers have explicitly taken advantage of widespread public interest in COVID-1...

    Authors: Eric B. Kennedy, Mia Charifson, Megan Jehn, Eric A. Jensen and Jenna Vikse
    Citation: BMC Medical Research Methodology 2022 22:251
  9. Missing data are ubiquitous in randomised controlled trials. Although sensitivity analyses for different missing data mechanisms (missing at random vs. missing not at random) are widely recommended, they are r...

    Authors: Andreas Staudt, Jennis Freyer-Adam, Till Ittermann, Christian Meyer, Gallus Bischof, Ulrich John and Sophie Baumann
    Citation: BMC Medical Research Methodology 2022 22:250
  10. Participant recruitment is one of the main challenges in research. It is suggested that including researcher photographs might increase participation rates, but empirical evidence is lacking. This study within...

    Authors: Barbara Prediger, Nadja Könsgen, Ana-Mihaela Bora, Anna Schlimbach and Dawid Pieper
    Citation: BMC Medical Research Methodology 2022 22:249
  11. Previous studies support cultural tailoring of recruitment materials as a strategy to promote the enrollment of minoritized groups in clinical trials. However, there is a lack of guidance for research teams to...

    Authors: Jennifer Cunningham-Erves, Sheila V. Kusnoor, Victoria Villalta-Gil, Sarah C. Stallings, Jabari S. Ichimura, Tiffany L. Israel, Paul A. Harris and Consuelo H. Wilkins
    Citation: BMC Medical Research Methodology 2022 22:248
  12. The Posttraumatic growth inventory (PTGI) aims to assess the positive psychological changes that individuals can perceive after a traumatic life event such as a cancer diagnosis. Several French translations of...

    Authors: Yseulys Dubuy, Véronique Sébille, Marianne Bourdon, Jean-Benoit Hardouin and Myriam Blanchin
    Citation: BMC Medical Research Methodology 2022 22:246
  13. The ARena study (Sustainable Reduction of Antimicrobial Resistance in German Ambulatory Care) is a three-arm, cluster randomized trial to evaluate a multifaceted implementation program in a German primary care...

    Authors: Lukas Kühn, Dorothea Kronsteiner, Petra Kaufmann-Kolle, Edith Andres, Joachim Szecsenyi, Michel Wensing and Regina Poss-Doering
    Citation: BMC Medical Research Methodology 2022 22:243
  14. A sample size justification is required for all studies and should give the minimum number of subjects to be recruited for the study to achieve its primary objective. The aim of this review is to describe samp...

    Authors: Oscar Han, Hao Wei Tan, Steven Julious, Laura Sutton, Richard Jacques, Ellen Lee, Jen Lewis and Stephen Walters
    Citation: BMC Medical Research Methodology 2022 22:242
  15. Many studies rely on self-reported height and weight. While a substantial body of literature exists on misreporting of height and weight, little exists on improving accuracy. The aim of this study was to deter...

    Authors: Nina Van Dyke, Eric J. Drinkwater and Jerome N. Rachele
    Citation: BMC Medical Research Methodology 2022 22:241
  16. One of the most important formats to disseminate the evidence in health to different populations are Cochrane Plain Language Summaries (PLSs). PLSs should be written in a simplified language, easily understand...

    Authors: Aleksandra Banić, Mahir Fidahić, Jelena Šuto, Rea Roje, Ivana Vuka, Livia Puljak and Ivan Buljan
    Citation: BMC Medical Research Methodology 2022 22:240
  17. Risk-prediction tools allow classifying individuals into risk groups based on risk thresholds. Such risk categorization is often used to inform screening schemes by offering screening only to individuals at in...

    Authors: Vinzenz Voelkel, Teresa Draeger, Sietse van Mossel, Sabine Siesling and Hendrik Koffijberg
    Citation: BMC Medical Research Methodology 2022 22:239
  18. We provide an overview of Bayesian estimation, hypothesis testing, and model-averaging and illustrate how they benefit parametric survival analysis. We contrast the Bayesian framework to the currently dominant...

    Authors: František Bartoš, Frederik Aust and Julia M. Haaf
    Citation: BMC Medical Research Methodology 2022 22:238
  19. Public health research frequently relies on collaborations with community-based organizations, and these partnerships can be essential to the success of a project. However, while public health ethics and overs...

    Authors: Rebecca Fielding-Miller, Sarah Kim, Jeanette Bowles, Samantha Streuli and Peter Davidson
    Citation: BMC Medical Research Methodology 2022 22:237
  20. Previous research has demonstrated that individual risk of mental illness is associated with individual, co-resident, and household risk factors. However, modelling the overall effect of these risk factors pre...

    Authors: Hend Gabr, Mohammed Baragilly and Brian H. Willis
    Citation: BMC Medical Research Methodology 2022 22:236
  21. A classic methodology used in evaluating the impact of health policy interventions is interrupted time-series (ITS) analysis, applying a quasi-experimental design that uses both pre- and post-policy data witho...

    Authors: Huan Jiang, Xinyang Feng, Shannon Lange, Alexander Tran, Jakob Manthey and Jürgen Rehm
    Citation: BMC Medical Research Methodology 2022 22:235
  22. Systematic reviews that synthesize safety outcomes pose challenges (e.g. rare events), which raise questions for grading the strength of the body of evidence. This is maybe one reason why in many potentially i...

    Authors: Tim Mathes, Nina-Kristin Mann, Petra Thürmann, Andreas Sönnichsen and Dawid Pieper
    Citation: BMC Medical Research Methodology 2022 22:234
  23. One critical variable in the time series analysis is the change point, which is the point where an abrupt change occurs in chronologically ordered observations. Existing parametric models for change point dete...

    Authors: Xiang Chen, Hui Wang, Weixuan Lyu and Ran Xu
    Citation: BMC Medical Research Methodology 2022 22:233
  24. Interrater reliability, aka intercoder reliability, is defined as true agreement between raters, aka coders, without chance agreement. It is used across many disciplines including medical and health research t...

    Authors: Xinshu Zhao, Guangchao Charles Feng, Song Harris Ao and Piper Liping Liu
    Citation: BMC Medical Research Methodology 2022 22:232
  25. Retention (participants completing a trial) is a persistent, and often under-studied, challenge within clinical trials. Research on retention has focussed on understanding the actions of participants who decid...

    Authors: Taylor Coffey, Eilidh Duncan, Heather Morgan and Katie Gillies
    Citation: BMC Medical Research Methodology 2022 22:231
  26. Restrictions in systematic reviews (SRs) can lead to bias and may affect conclusions. Therefore, it is important to report whether and which restrictions were used. This study aims to examine the use of restri...

    Authors: Jasmin Helbach, Dawid Pieper, Tim Mathes, Tanja Rombey, Hajo Zeeb, Katharina Allers and Falk Hoffmann
    Citation: BMC Medical Research Methodology 2022 22:230
  27. An increasing number of large-scale multi-modal research initiatives has been conducted in the typically developing population, e.g. Dev. Cogn. Neur. 32:43-54, 2018; PLoS Med. 12(3):e1001779, 2015; Elam and Van E...

    Authors: A. Llera, M. Brammer, B. Oakley, J. Tillmann, M. Zabihi, J. S. Amelink, T. Mei, T. Charman, C. Ecker, F. Dell’Acqua, T. Banaschewski, C. Moessnang, S. Baron-Cohen, R. Holt, S. Durston, D. Murphy…
    Citation: BMC Medical Research Methodology 2022 22:229
  28. Platform trials can evaluate the efficacy of several experimental treatments compared to a control. The number of experimental treatments is not fixed, as arms may be added or removed as the trial progresses. ...

    Authors: Marta Bofill Roig, Pavla Krotka, Carl-Fredrik Burman, Ekkehard Glimm, Stefan M. Gold, Katharina Hees, Peter Jacko, Franz Koenig, Dominic Magirr, Peter Mesenbrink, Kert Viele and Martin Posch
    Citation: BMC Medical Research Methodology 2022 22:228
  29. Studies have shown that data collection by medical record abstraction (MRA) is a significant source of error in clinical research studies relying on secondary use data. Yet, the quality of data collected using...

    Authors: Maryam Y. Garza, Tremaine Williams, Sahiti Myneni, Susan H. Fenton, Songthip Ounpraseuth, Zhuopei Hu, Jeannette Lee, Jessica Snowden, Meredith N. Zozus, Anita C. Walden, Alan E. Simon, Barbara McClaskey, Sarah G. Sanders, Sandra S. Beauman, Sara R. Ford, Lacy Malloch…
    Citation: BMC Medical Research Methodology 2022 22:227
  30. When interested in a time-to-event outcome, competing events that prevent the occurrence of the event of interest may be present. In the presence of competing events, various estimands have been suggested for ...

    Authors: Elisavet Syriopoulou, Sarwar I. Mozumder, Mark J. Rutherford and Paul C. Lambert
    Citation: BMC Medical Research Methodology 2022 22:226
  31. The use of routine data will be essential in future healthcare research. Therefore, harmonizing procedure codes is a first step to facilitate this approach as international research endeavour. An example for t...

    Authors: Sibylle C. Mellinghoff, Caroline Bruns, Rouvier Al-Monajjed, Florian B. Cornely, Maria Grosheva, Jürgen A. Hampl, Carolin Jakob, Felix C. Koehler, Max Lechmann, Bijan Maged, Christina Otto-Lambertz, Robert Rongisch, Jule Rutz, Jon Salmanton-Garcia, Georg Schlachtenberger, Jannik Stemler…
    Citation: BMC Medical Research Methodology 2022 22:225
  32. Meaningfully interpreting patient-reported outcomes (PRO) results from randomized clinical trials requires that the PRO scores obtained in the trial have the same meaning across patients and previous applicati...

    Authors: Angély Loubert, Antoine Regnault, Véronique Sébille and Jean-Benoit Hardouin
    Citation: BMC Medical Research Methodology 2022 22:224
  33. Depression is common in the human immunodeficiency virus (HIV)-hepatitis C virus (HCV) co-infected population. Demographic, behavioural, and clinical data collected in research settings may be of help in ident...

    Authors: Gayatri Marathe, Erica E. M. Moodie, Marie-Josée Brouillette, Joseph Cox, Curtis Cooper, Charlotte Lanièce Delaunay, Brian Conway, Mark Hull, Valérie Martel-Laferrière, Marie-Louise Vachon, Sharon Walmsley, Alexander Wong and Marina B. Klein
    Citation: BMC Medical Research Methodology 2022 22:223
  34. Cluster randomised trials (CRTs) are often designed with a small number of clusters, but it is not clear which analysis methods are optimal when the outcome is binary. This simulation study aimed to determine ...

    Authors: Jennifer A. Thompson, Clemence Leyrat, Katherine L. Fielding and Richard J. Hayes
    Citation: BMC Medical Research Methodology 2022 22:222
  35. In response to the COVID-19 pandemic many clinical studies have been initiated leading to the need for efficient ways to track and analyze study results. We expanded our previous project that tracked registere...

    Authors: Craig S. Mayer and Vojtech Huser
    Citation: BMC Medical Research Methodology 2022 22:221
  36. To identify and describe the use of the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach for rating the certainty of systematic reviews (SRs) evidence published in urology an...

    Authors: Shuang Zhang, Qi-Jun Wu and Shu-Xin Liu
    Citation: BMC Medical Research Methodology 2022 22:220
  37. To measure the specific effectiveness of a given treatment in a randomised controlled trial, the intervention and control groups have to be similar in all factors not distinctive to the experimental treatment....

    Authors: D.’Alessandro Giandomenico, Ruffini Nuria, Aquino Alessandro, Galli Matteo, Innocenti Mattia, Tramontano Marco and Cerritelli Francesco
    Citation: BMC Medical Research Methodology 2022 22:219
  38. Diagnosing urinary tract infections (UTIs) in children in the emergency department (ED) is challenging due to the variable clinical presentations and difficulties in obtaining a urine sample free from contamin...

    Authors: Jessica A. Ramsay, Steven Mascaro, Anita J. Campbell, David A. Foley, Ariel O. Mace, Paul Ingram, Meredith L. Borland, Christopher C. Blyth, Nicholas G. Larkins, Tim Robertson, Phoebe C. M. Williams, Thomas L. Snelling and Yue Wu
    Citation: BMC Medical Research Methodology 2022 22:218
  39. Anchored covariate-adjusted indirect comparisons inform reimbursement decisions where there are no head-to-head trials between the treatments of interest, there is a common comparator arm shared by the studies...

    Authors: Antonio Remiro-Azócar
    Citation: BMC Medical Research Methodology 2022 22:217
  40. Long-term prophylactic therapy is considered the standard of care for hemophilia A patients. This study models the long-term clinical and cost outcomes of two factor VIII (FVIII) products using a pharmacokinet...

    Authors: Rong Chen, Dmitry Gultyaev, Johanna Lister, Rong Han, Nan Hu, Jean Malacan, Alexander Solms, Parth Vashi, Jamie O’Hara and Shanlian Hu
    Citation: BMC Medical Research Methodology 2022 22:215
  41. Adolescent pregnancies and sexually-transmitted infections continue to impact 15 – 19-year-olds across the globe. The lack of sexual reproductive health information (SRH) in resource-limited settings due to cu...

    Authors: Paul Macharia, Antoni Pérez-Navarro, Irene Inwani, Ruth Nduati and Carme Carrion
    Citation: BMC Medical Research Methodology 2022 22:213
  42. Models, theories, and frameworks (MTFs) provide the foundation for a cumulative science of implementation, reflecting a shared, evolving understanding of various facets of implementation. One under-represented...

    Authors: Justin Presseau, Danielle Kasperavicius, Isabel Braganca Rodrigues, Jessica Braimoh, Andrea Chambers, Cole Etherington, Lora Giangregorio, Jenna C. Gibbs, Anik Giguere, Ian D. Graham, Olena Hankivsky, Alison M. Hoens, Jayna Holroyd-Leduc, Christine Kelly, Julia E. Moore, Matteo Ponzano…
    Citation: BMC Medical Research Methodology 2022 22:212
  43. Hospital length of stay (LOS) is a key indicator of hospital care management efficiency, cost of care, and hospital planning. Hospital LOS is often used as a measure of a post-medical procedure outcome, as a g...

    Authors: Gustavo A. Fernandez and Kristina P. Vatcheva
    Citation: BMC Medical Research Methodology 2022 22:211

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