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  1. There is increasing interest in clinical prediction models for rare outcomes such as suicide, psychiatric hospitalizations, and opioid overdose. Accurate model validation is needed to guide model selection and...

    Authors: R Yates Coley, Qinqing Liao, Noah Simon and Susan M. Shortreed
    Citation: BMC Medical Research Methodology 2023 23:33
    Content type: Research article Published on:

  2. Authors: Gloria A. Aguayo, Lu Zhang, Michel Vaillant, Moses Ngari, Magali Perquin, Valerie Moran, Laetitia Huiart, Rejko Krüger, Francisco Azuaje, Cyril Ferdynus and Guy Fagherazzi
    Citation: BMC Medical Research Methodology 2023 23:32
    Content type: Correction Published on:

    The original article was published in BMC Medical Research Methodology 2023 23:8

  3. A previously developed decision model to prioritize surgical procedures in times of scarce surgical capacity used quality of life (QoL) primarily derived from experts in one center. These estimates are key inp...

    Authors: Benjamin Y. Gravesteijn, Kira S. van Hof, Eline Krijkamp, Franck Asselman, C. René Leemans, Anouk M.I.A. van Alphen, Henriëtte van der Horst, Guy Widdershoven, Leonie Baatenburg de Jong, Hester Lingsma, Jan Busschbach and Rob Baatenburg de Jong
    Citation: BMC Medical Research Methodology 2023 23:31
    Content type: Research Published on:

  4. Diagnostic tests are important in clinical medicine. To determine the test performance indices — test sensitivity, specificity, likelihood ratio, predictive values, etc. — the test results should be compared a...

    Authors: Farrokh Habibzadeh and Hooman Roozbehi
    Citation: BMC Medical Research Methodology 2023 23:30
    Content type: Research Published on:

  7. The registration of clinical trials is required by law in Switzerland. We investigated (1) the proportion of registered and prospectively registered clinical trials, (2) the availability of results for ethical...

    Authors: Katharina Klatte, Constantin Sluka, Viktoria Gloy, Ala Taji Heravi, Christof Schönenberger, Nienke Jones, Elena Brunnschweiler, Christiane Pauli-Magnus and Matthias Briel
    Citation: BMC Medical Research Methodology 2023 23:27
    Content type: Research Published on:

  8. Authors: R. K. Ismail, F. M. N. H. Schramel, M. van Dartel, A. M. G. Pasmooij, C. M. Cramer-van der Welle, D. L. Hilarius, A. de Boer, M. W. J. M. Wouters and E. M. W. van de Garde
    Citation: BMC Medical Research Methodology 2023 23:26
    Content type: Correction Published on:

    The original article was published in BMC Medical Research Methodology 2023 23:1

  9. Numerous clinical trials have been initiated to find effective treatments for COVID-19. These trials have often been initiated in regions where the pandemic has already peaked. Consequently, achieving full enr...

    Authors: Danni Wu, Keith S. Goldfeld and Eva Petkova
    Citation: BMC Medical Research Methodology 2023 23:25
    Content type: Research Published on:

  10. One of the main challenges of the COVID-19 pandemic is to make sense of available, but often heterogeneous and noisy data. This contribution presents a data-driven methodology that allows exploring the hospita...

    Authors: Alberto Aleta, Juan Luis Blas-Laína, Gabriel Tirado Anglés and Yamir Moreno
    Citation: BMC Medical Research Methodology 2023 23:24
    Content type: Research Published on:

  11. Multivariate longitudinal data are under-utilized for survival analysis compared to cross-sectional data (CS - data collected once across cohort). Particularly in cardiovascular risk prediction, despite availa...

    Authors: Hieu T. Nguyen, Henrique D. Vasconcellos, Kimberley Keck, Jared P. Reis, Cora E. Lewis, Steven Sidney, Donald M. Lloyd-Jones, Pamela J. Schreiner, Eliseo Guallar, Colin O. Wu, João A.C. Lima and Bharath Ambale-Venkatesh
    Citation: BMC Medical Research Methodology 2023 23:23
    Content type: Research Published on:

  12. The Pooled Cohort Equations (PCEs) are race- and sex-specific Cox proportional hazards (PH)-based models used for 10-year atherosclerotic cardiovascular disease (ASCVD) risk prediction with acceptable discrimi...

    Authors: Yu Deng, Lei Liu, Hongmei Jiang, Yifan Peng, Yishu Wei, Zhiyang Zhou, Yizhen Zhong, Yun Zhao, Xiaoyun Yang, Jingzhi Yu, Zhiyong Lu, Abel Kho, Hongyan Ning, Norrina B. Allen, John T. Wilkins, Kiang Liu…
    Citation: BMC Medical Research Methodology 2023 23:22
    Content type: Research Published on:

  13. Patient-reported physical function (PF) is a key endpoint in cancer clinical trials. Using complex statistical methods, common metrics have been developed to compare scores from different patient-reported outc...

    Authors: T Schurr, F Loth, E Lidington, C Piccinin, JI Arraras, M Groenvold, B Holzner, M van Leeuwen, MA Petersen, H Schmidt, T Young and JM Giesinger
    Citation: BMC Medical Research Methodology 2023 23:21
    Content type: Research Published on:

  14. Reporting quality is a critical issue in health sciences. Adopting the reporting guidelines has been approved to be an effective way of enhancing the reporting quality and transparency of clinical research. In...

    Authors: Yuting Duan, Lingyun Zhao, Yanfang Ma, Jingyuan Luo, Juexuan Chen, Jiangxia Miao, Xuan Zhang, David Moher and Zhaoxiang Bian
    Citation: BMC Medical Research Methodology 2023 23:20
    Content type: Research article Published on:

  15. Advantages of meta-analysis depend on the assumptions underlying the statistical procedures used being met. One of the main assumptions that is usually taken for granted is the normality underlying the populat...

    Authors: Desirée Blázquez-Rincón, Julio Sánchez-Meca, Juan Botella and Manuel Suero
    Citation: BMC Medical Research Methodology 2023 23:19
    Content type: Research Published on:

  16. To have confidence in one's interpretation of treatment effects assessed by comparing trial results to external controls, minimizing bias is a critical step. We sought to investigate different methods for caus...

    Authors: Jinma Ren, Paul Cislo, Joseph C. Cappelleri, Patrick Hlavacek and Marco DiBonaventura
    Citation: BMC Medical Research Methodology 2023 23:18
    Content type: Research Published on:

  17. Ensuring motivated and successful study participation is a key challenge in the design and conduct of health research studies. Previously, recruitment barriers and facilitators have been identified mainly from...

    Authors: Jonas Lander, Andrea Heiberger, Julia Von Sommoggy, Anja Alexandra Schulz, Carolin Dresch, Hala Altawil, Gwendolyn Schmitt and Markus Antonius Wirtz
    Citation: BMC Medical Research Methodology 2023 23:17
    Content type: Research Published on:

  18. High quality longitudinal studies investigating changes in health behaviours over the transition into early adulthood are critical. However, recruiting and retaining adolescents is challenging. This study expl...

    Authors: Stephanie T. Jong, Rebecca Stevenson, Eleanor M. Winpenny, Kirsten Corder and Esther M. F. van Sluijs
    Citation: BMC Medical Research Methodology 2023 23:16
    Content type: Research Published on:

  19. Surveys are common research tools, and questionnaires revisions are a common occurrence in longitudinal studies. Revisions can, at times, introduce systematic shifts in measures of interest. We formulate that ...

    Authors: Chung-Han Liang, Da-Wei Wang and Mei-Lien Pan
    Citation: BMC Medical Research Methodology 2023 23:15
    Content type: Research Published on:

  20. Accurately estimating elderly patients’ rehospitalisation risk benefits clinical decisions and service planning. However, research in rehospitalisation and repeated hospitalisation yielded only models with mod...

    Authors: Jingjing Guan, Eman Leung, Kin-on Kwok and Frank Youhua Chen
    Citation: BMC Medical Research Methodology 2023 23:14
    Content type: Research Published on:

  21. Country-specific value sets for the EQ-5D are available which reflect preferences for health states elicited from the general population. This allows the transformation of responses on EQ-5D to health state ut...

    Authors: Ayesha Sajjad, Matthijs M. Versteegh, Irene Santi, Jan Busschbach, Judit Simon and Leona Hakkaart-van Roijen
    Citation: BMC Medical Research Methodology 2023 23:13
    Content type: Research Published on:

  22. When evaluating the impact of environmental exposures on human health, study designs often include a series of repeated measurements. The goal is to determine whether populations have different trajectories of...

    Authors: Kylie K. Harrall, Keith E. Muller, Anne P. Starling, Dana Dabelea, Kelsey E. Barton, John L. Adgate and Deborah H. Glueck
    Citation: BMC Medical Research Methodology 2023 23:12
    Content type: Research Published on:

  23. Confounding is a common issue in epidemiological research. Commonly used confounder-adjustment methods include multivariable regression analysis and propensity score methods. Although it is common practice to ...

    Authors: Noah A. Schuster, Judith J. M. Rijnhart, Lisa C. Bosman, Jos W. R. Twisk, Thomas Klausch and Martijn W. Heymans
    Citation: BMC Medical Research Methodology 2023 23:11
    Content type: Research Published on:

  24. Novel survey methods are needed to tackle declining response rates. The 2020 National Maternity Survey included a randomised controlled trial (RCT) and social media survey to compare different combinations of ...

    Authors: Siân Harrison, Fiona Alderdice and Maria A. Quigley
    Citation: BMC Medical Research Methodology 2023 23:10
    Content type: Research Published on:

    The Correction to this article has been published in BMC Medical Research Methodology 2023 23:28

  26. In the older general population, neurodegenerative diseases (NDs) are associated with increased disability, decreased physical and cognitive function. Detecting risk factors can help implement prevention measu...

    Authors: Gloria A. Aguayo, Lu Zhang, Michel Vaillant, Moses Ngari, Magali Perquin, Valerie Moran, Laetitia Huiart, Rejko Krüger, Francisco Azuaje, Cyril Ferdynus and Guy Fagherazzi
    Citation: BMC Medical Research Methodology 2023 23:8
    Content type: Research Published on:

    The Correction to this article has been published in BMC Medical Research Methodology 2023 23:32

  28. Studies reporting statistically significant effect estimates tend to be more frequently published compared to studies reporting non-significant or equivalent estimates. Consequently, this may lead to distortio...

    Authors: Jadbinder Seehra, Hadil Khraishi and Nikolaos Pandis
    Citation: BMC Medical Research Methodology 2023 23:6
    Content type: Research Published on:

  29. In the development of prediction models for a clinical event, it is common to use the static prediction modeling (SPM), a regression model that relates baseline predictors to the time to event. In many situati...

    Authors: Yi Yao, Liang Li, Brad Astor, Wei Yang and Tom Greene
    Citation: BMC Medical Research Methodology 2023 23:5
    Content type: Research Published on:

  30. Clinical information collected in electronic health records (EHRs) is becoming an essential source to emulate randomized experiments. Since patients do not interact with the healthcare system at random, the lo...

    Authors: Sumeet Kalia, Olli Saarela, Michael Escobar, Rahim Moineddin and Michelle Greiver
    Citation: BMC Medical Research Methodology 2023 23:4
    Content type: Research Published on:

  31. In inter-rater agreement studies, the assessment behaviour of raters can be influenced by their experience, training levels, the degree of willingness to take risks, and the availability of clear guidelines fo...

    Authors: Haydar Demirhan and Ayfer Ezgi Yilmaz
    Citation: BMC Medical Research Methodology 2023 23:3
    Content type: Research Published on:

  32. Due to the high cost and high failure rate of Phase III trials where a classical group sequential design (GSD) is usually used, seamless Phase II/III designs are more and more popular to improve trial efficien...

    Authors: Guanhong Miao, Jason J. Z. Liao, Jing Yang and Keaven Anderson
    Citation: BMC Medical Research Methodology 2023 23:2
    Content type: Research Published on:

  33. Many studies have compared real-world clinical outcomes of immunotherapy in patients with metastatic non-small cell lung cancer (NSCLC) with reported outcomes data from pivotal trials. However, any differences...

    Authors: R. K. Ismail, F. M. N. H. Schramel, M. van Dartel, A. M. G. Pasmooij, C. M. Cramer-van der Welle, D. L. Hilarius, A. de Boer, M. W. J. M. Wouters and E. M. W. van de Garde
    Citation: BMC Medical Research Methodology 2023 23:1
    Content type: Research Published on:

    The Correction to this article has been published in BMC Medical Research Methodology 2023 23:26

  34. The high number of COVID-19 deaths is a serious threat to the world. Demographic and clinical biomarkers are significantly associated with the mortality risk of this disease. This study aimed to implement Gene...

    Authors: Samad Moslehi, Hossein Mahjub, Maryam Farhadian, Ali Reza Soltanian and Mojgan Mamani
    Citation: BMC Medical Research Methodology 2022 22:339
    Content type: Research Published on:

  35. CVD-patients with higher levels of cardiac anxiety suffer psychologically, as well as being at increased risk for cardiac morbidity and mortality. Therefore it is important to be able to assess CA in a clinica...

    Authors: Philip Leissner, Claes Held, Elisabet Rondung and Erik M. G. Olsson
    Citation: BMC Medical Research Methodology 2022 22:338
    Content type: Research Published on:

  36. Estimating the average effect of a treatment, exposure, or intervention on health outcomes is a primary aim of many medical studies. However, unbalanced covariates between groups can lead to confounding bias w...

    Authors: Jiaqin Xu, Kecheng Wei, Ce Wang, Chen Huang, Yaxin Xue, Rui Zhang, Guoyou Qin and Yongfu Yu
    Citation: BMC Medical Research Methodology 2022 22:337
    Content type: Research Published on:

  37. Many metagenomic studies have linked the imbalance in microbial abundance profiles to a wide range of diseases. These studies suggest utilizing the microbial abundance profiles as potential markers for metagen...

    Authors: Mustafa Alshawaqfeh, Salahelden Rababah, Abdullah Hayajneh, Ammar Gharaibeh and Erchin Serpedin
    Citation: BMC Medical Research Methodology 2022 22:336
    Content type: Software Published on:

  38. An external control arm is a cohort of control patients that are collected from data external to a single-arm trial. To provide an unbiased estimation of efficacy, the clinical profiles of patients from single...

    Authors: Nicolas Loiseau, Paul Trichelair, Maxime He, Mathieu Andreux, Mikhail Zaslavskiy, Gilles Wainrib and Michael G. B. Blum
    Citation: BMC Medical Research Methodology 2022 22:335
    Content type: Research article Published on:

  39. For over three decades researchers have developed critical appraisal tools (CATs) for assessing the scientific quality of research overviews. Most established CATs for reviews in evidence-based medicine and ev...

    Authors: Thomas L. Heise, Andreas Seidler, Maria Girbig, Alice Freiberg, Adrienne Alayli, Maria Fischer, Wolfgang Haß and Hajo Zeeb
    Citation: BMC Medical Research Methodology 2022 22:334
    Content type: Research Published on:

  40. Modern configurational comparative methods (CCMs) of causal inference, such as Qualitative Comparative Analysis (QCA) and Coincidence Analysis (CNA), have started to make inroads into medical and health resear...

    Authors: Alrik Thiem, Lusine Mkrtchyan and Zuzana Sebechlebská
    Citation: BMC Medical Research Methodology 2022 22:333
    Content type: Research Published on:

  41. The Rasch model allows for linear measurement based on ordinal item responses from rating scales commonly used to assess health outcomes. Such linear measures may be inconvenient since they are expressed as lo...

    Authors: Joakim Ekstrand, Albert Westergren, Kristofer Årestedt, Amanda Hellström and Peter Hagell
    Citation: BMC Medical Research Methodology 2022 22:332
    Content type: Research Published on:

  42. Machine learning has been used to develop predictive models to support clinicians in making better and more reliable decisions. The high volume of collected data in the lung transplant process makes it possibl...

    Authors: Marsa Gholamzadeh, Hamidreza Abtahi and Reza Safdari
    Citation: BMC Medical Research Methodology 2022 22:331
    Content type: Research Published on:

  43. Identifying mechanisms to maintain CBPR studies during an infectious disease pandemic is vital. The current paper describes the changes in methods and processes conducted within a CBPR mixed-methods study to a...

    Authors: Nicole Farmer, Ralph Thadeus Tuason, Narjis Kazmi, Sharon Flynn, Valerie Mitchell, Kimberly Middleton, Robert Cox, Kristina Franklin, Talya Gordon, Alyssa Baginski and Gwenyth R. Wallen
    Citation: BMC Medical Research Methodology 2022 22:330
    Content type: Research article Published on:

  44. Many clinical practice guidelines are based on randomised controlled trials conducted in secondary or tertiary care setting and general practitioners frequently question their relevance for primary care patien...

    Authors: Amandine Dugard, Elsa Tavernier, Agnès Caille, Agnès Dechartres, Adeline Hoang, Bruno Giraudeau and Clarisse Dibao-Dina
    Citation: BMC Medical Research Methodology 2022 22:329
    Content type: Research Published on:

  45. Precision medicine is an emerging field that involves the selection of treatments based on patients’ individual prognostic data. It is formalized through the identification of individualized treatment rules (I...

    Authors: Gilson D. Honvoh, Hunyong Cho and Michael R. Kosorok
    Citation: BMC Medical Research Methodology 2022 22:328
    Content type: Research Published on:

  46. Due to economical and ethical reasons, the two-stage designs have been widely used for Phase 2 single-arm trials in oncology because the designs allow us to stop the trial early if the proposed treatment is li...

    Authors: Wonsuk Yoo, Seongho Kim, Michael Garcia, Shwetal Mehta and Nader Sanai
    Citation: BMC Medical Research Methodology 2022 22:327
    Content type: Research Published on:

  47. Availability of linked biomedical and social science data has risen dramatically in past decades, facilitating holistic and systems-based analyses. Among these, Bayesian networks have great potential to tackle...

    Authors: Xuejia Ke, Katherine Keenan and V. Anne Smith
    Citation: BMC Medical Research Methodology 2022 22:326
    Content type: Research Published on:

  48. Prognostic information for patients with hypertension is largely based on population averages. The purpose of this study was to compare the performance of four machine learning approaches for personalized pred...

    Authors: Yuanchao Feng, Alexander A. Leung, Xuewen Lu, Zhiying Liang, Hude Quan and Robin L. Walker
    Citation: BMC Medical Research Methodology 2022 22:325
    Content type: Research Published on:

  49. The role of immunological responses to exposed bacteria on disease incidence is increasingly under investigation. With many bacterial species, and many potential antibody reactions to a particular species, the...

    Authors: Tanvi Mehta, Yaakov Malinovsky, Christian C. Abnet and Paul S. Albert
    Citation: BMC Medical Research Methodology 2022 22:324
    Content type: Research Published on:

  50. Research about the decision to participate in a clinical study has tended to be limited to single indications and has focused on narrow sets of study and participant characteristics. This study applied stated ...

    Authors: Caitlin Thomas, Sarah Mulnick, Nicolas Krucien and Kevin Marsh
    Citation: BMC Medical Research Methodology 2022 22:323
    Content type: Research Published on:
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BMC Medical Research Methodology

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