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  1. Contact tracing data of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is used to estimate basic epidemiological parameters. Contact tracing data could also be potentially used for assessin...

    Authors: Karikalan Nagarajan, Malaisamy Muniyandi, Bharathidasan Palani and Senthil Sellappan

    Citation: BMC Medical Research Methodology 2020 20:233

    Content type: Research article

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  2. Psychiatric disorders may occur as a single episode or be persistent and relapsing, sometimes leading to suicidal behaviours. The exact causes of psychiatric disorders are hard to determine but easy access to ...

    Authors: Sharmin Sharker, Lloyd Balbuena, Gene Marcoux and Cindy Xin Feng

    Citation: BMC Medical Research Methodology 2020 20:232

    Content type: Research article

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  3. Emergency Departments (EDs) are a first point-of-contact for many youth with mental health and suicidality concerns and can serve as an effective recruitment source for randomized controlled trials (RCTs) of m...

    Authors: Matthew Tracey, Yaron Finkelstein, Reva Schachter, Kristin Cleverley, Suneeta Monga, Melanie Barwick, Peter Szatmari, Myla E. Moretti, Andrew Willan, Joanna Henderson and Daphne J. Korczak

    Citation: BMC Medical Research Methodology 2020 20:231

    Content type: Research article

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  4. Master of public health (MPH) plays an important role in Chinese medical education, and the dissertations is an important part of MPH education. In MPH dissertations, most are observational studies. Compared w...

    Authors: Shuangyang Dai, Xiaobin Zhou, Hong Xu, Beibei Li and Jingao Zhang

    Citation: BMC Medical Research Methodology 2020 20:230

    Content type: Research article

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  5. Defining incident cases has always been a challenging issue for researchers working with routine data. Lookback periods should enable researchers to identify and exclude recurrent cases and increase the accura...

    Authors: Jelena Epping, Siegfried Geyer and Juliane Tetzlaff

    Citation: BMC Medical Research Methodology 2020 20:229

    Content type: Research article

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  6. COVID-19, the disease caused by the highly infectious and transmissible coronavirus SARS-CoV-2, has quickly become a morbid global pandemic. Although the impact of SARS-CoV-2 infection in children is less clin...

    Authors: Rosiane Lima, Elizabeth F. Gootkind, Denis De la Flor, Laura J. Yockey, Evan A. Bordt, Paolo D’Avino, Shen Ning, Katerina Heath, Katherine Harding, Jaclyn Zois, Grace Park, Margot Hardcastle, Kathleen A. Grinke, Sheila Grimmel, Susan P. Davidson, Pamela J. Forde…

    Citation: BMC Medical Research Methodology 2020 20:228

    Content type: Research article

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  7. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Junhao Liu, Jo Wick, Renee’ H. Martin, Caitlyn Meinzer, Dooti Roy and Byron Gajewski

    Citation: BMC Medical Research Methodology 2020 20:227

    Content type: Correction

    Published on:

    The original article was published in BMC Medical Research Methodology 2020 20:211

  8. Methodological studies – studies that evaluate the design, analysis or reporting of other research-related reports – play an important role in health research. They help to highlight issues in the conduct of r...

    Authors: Lawrence Mbuagbaw, Daeria O. Lawson, Livia Puljak, David B. Allison and Lehana Thabane

    Citation: BMC Medical Research Methodology 2020 20:226

    Content type: Commentary

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  9. Claims databases are generally considered inadequate for obesity research due to suboptimal capture of body mass index (BMI) measurements. This might not be true for bariatric surgery because of reimbursement ...

    Authors: Xiaojuan Li, Kristina H. Lewis, Katherine Callaway, J. Frank Wharam and Sengwee Toh

    Citation: BMC Medical Research Methodology 2020 20:225

    Content type: Research article

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  10. Clinical Trials (CTs) help in testing and validating the safety and efficacy of newly discovered drugs on specific patient population cohorts. However, these trials usually experience many challenges, such as ...

    Authors: Ilhaam A. Omar, Raja Jayaraman, Khaled Salah, Mecit Can Emre Simsekler, Ibrar Yaqoob and Samer Ellahham

    Citation: BMC Medical Research Methodology 2020 20:224

    Content type: Technical advance

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  11. Health-related quality of life (HRQoL) has become a major endpoint to assess the clinical benefit of new therapeutic strategies in oncology clinical trials. Typically, HRQoL outcomes are analyzed using linear ...

    Authors: B. Cuer, C. Mollevi, A. Anota, E. Charton, B. Juzyna, T. Conroy and C. Touraine

    Citation: BMC Medical Research Methodology 2020 20:223

    Content type: Research article

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  12. Parallel intervention studies involving volunteers usually require a procedure to allocate the subjects to study-arms. Statistical models to evaluate the different outcomes of the study-arms will include study...

    Authors: Eric D. Schoen and Suzan Wopereis

    Citation: BMC Medical Research Methodology 2020 20:222

    Content type: Technical advance

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  13. Event-related potentials (ERP) data are widely used in brain studies that measure brain responses to specific stimuli using electroencephalogram (EEG) with multiple electrodes. Previous ERP data analyses haven...

    Authors: Ye Lin, Jianhui Zhou, Swapna Kumar, Wanze Xie, Sarah K. G. Jensen, Rashidul Haque, Charles A. Nelson, William A. Petri Jr and Jennie Z. Ma

    Citation: BMC Medical Research Methodology 2020 20:221

    Content type: Research article

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  14. Because of unknown features of the COVID-19 and the complexity of the population affected, standard clinical trial designs on treatments may not be optimal in such patients. We propose two independent clinical...

    Authors: Shesh N. Rai, Chen Qian, Jianmin Pan, Anand Seth, Deo Kumar Srivastava and Aruni Bhatnagar

    Citation: BMC Medical Research Methodology 2020 20:220

    Content type: Research article

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  15. Evaluating a candidate marker or developing a model for predicting risk of future conditions is one of the major goals in medicine. However, model development and assessment for a time-to-event outcome may be ...

    Authors: Rajib Dey, Giada Sebastiani and Paramita Saha-Chaudhuri

    Citation: BMC Medical Research Methodology 2020 20:219

    Content type: Technical advance

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  16. The data from immuno-oncology (IO) therapy trials often show delayed effects, cure rate, crossing hazards, or some mixture of these phenomena. Thus, the proportional hazards (PH) assumption is often violated s...

    Authors: Jason J. Z. Liao, G. Frank Liu and Wen-Chi Wu

    Citation: BMC Medical Research Methodology 2020 20:218

    Content type: Technical advance

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  17. Realist methodologies are increasingly being used to evaluate complex interventions in health and social care. Programme theory (ideas and assumptions of how a particular intervention works) development is the...

    Authors: Susanne Coleman, Judy M. Wright, Jane Nixon, Lisette Schoonhoven, Maureen Twiddy and Joanne Greenhalgh

    Citation: BMC Medical Research Methodology 2020 20:217

    Content type: Research article

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  18. This paper reports the construction and use of a specific method for qualitative medical research: The Inductive Process to Analyze the Structure of lived Experience (IPSE), an inductive and phenomenological appr...

    Authors: Jordan Sibeoni, Laurence Verneuil, Emilie Manolios and Anne Révah-Levy

    Citation: BMC Medical Research Methodology 2020 20:216

    Content type: Technical advance

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  19. Collection of biospecimens is a critical first step to understanding the impact of COVID-19 on pregnant women and newborns - vulnerable populations that are challenging to enroll and at risk of exclusion from ...

    Authors: Lydia L. Shook, Jessica E. Shui, Adeline A. Boatin, Samantha Devane, Natalie Croul, Lael M. Yonker, Juan D. Matute, Rosiane S. Lima, Muriel Schwinn, Dana Cvrk, Laurel Gardner, Robin Azevedo, Suzanne Stanton, Evan A. Bordt, Laura J. Yockey, Alessio Fasano…

    Citation: BMC Medical Research Methodology 2020 20:215

    Content type: Research article

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  20. Clinical uncertainty and equipoise are vague notions that play important roles in contemporary problems of medical care and research, including the design and conduct of pragmatic trials. Our goal was to show ...

    Authors: Robert Fahed, Tim E. Darsaut, Behzad Farzin, Miguel Chagnon and Jean Raymond

    Citation: BMC Medical Research Methodology 2020 20:214

    Content type: Research article

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  21. Although protocol registration of systematic reviews/meta-analysis (SR/MA) is still not mandatory, it is highly recommended that authors publish their SR/MA protocols prior to submitting their manuscripts for ...

    Authors: Gehad Mohamed Tawfik, Hoang Thi Nam Giang, Sherief Ghozy, Ahmed M. Altibi, Hend Kandil, Huu-Hoai Le, Peter Samuel Eid, Ibrahim Radwan, Omar Mohamed Makram, Tong Thi Thu Hien, Mahmoud Sherif, As-Saba Hossain, Tai Luu Lam Thang, Livia Puljak, Hosni Salem, Tarek Numair…

    Citation: BMC Medical Research Methodology 2020 20:213

    Content type: Research article

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  22. Monitoring and reporting of drug safety during a clinical trial is essential to its success. More recent attention to drug safety has encouraged statistical methods development for monitoring and detecting pot...

    Authors: Junhao Liu, Jo Wick, Renee’ H. Martin, Caitlyn Meinzer, Dooti Roy and Byron Gajewski

    Citation: BMC Medical Research Methodology 2020 20:211

    Content type: Research article

    Published on:

    The Correction to this article has been published in BMC Medical Research Methodology 2020 20:227

  23. Evidence is needed regarding effective incentive strategies to increase clinician survey response rates. Cash cards are increasingly used as survey incentives; they are appealing because of their convenience a...

    Authors: Lydia E. Pace, Yeonsoo S. Lee, Nadine Tung, Jada G. Hamilton, Camila Gabriel, Sahitya C. Raja, Colby Jenkins, Anthony Braswell, Susan M. Domchek, Heather Symecko, Kelsey Spielman, Beth Y. Karlan, Jenny Lester, Daniella Kamara, Jeffrey Levin, Kelly Morgan…

    Citation: BMC Medical Research Methodology 2020 20:210

    Content type: Research article

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  24. Severe asthma exerts a disproportionately heavy burden on patients and health care. Due to the heterogeneity of the severe asthma population, many patients need to be evaluated to understand the clinical featu...

    Authors: J. Mark FitzGerald, Trung N. Tran, Marianna Alacqua, Alan Altraja, Vibeke Backer, Leif Bjermer, Unnur Bjornsdottir, Arnaud Bourdin, Guy Brusselle, Lakmini Bulathsinhala, John Busby, Giorgio W. Canonica, Victoria Carter, Isha Chaudhry, You Sook Cho, George Christoff…

    Citation: BMC Medical Research Methodology 2020 20:212

    Content type: Research article

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  25. As the whole world is experiencing the cascading effect of a new pandemic, almost every aspect of modern life has been disrupted. Because of health emergencies during this period, widespread fear has resulted ...

    Authors: Atanu Bhattacharjee, Gajendra K. Vishwakarma, Souvik Banerjee and Sharvari Shukla

    Citation: BMC Medical Research Methodology 2020 20:209

    Content type: Research article

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  26. The coronavirus pandemic (Covid-19) presents a variety of challenges for ongoing clinical trials, including an inevitably higher rate of missing outcome data, with new and non-standard reasons for missingness....

    Authors: Suzie Cro, Tim P. Morris, Brennan C. Kahan, Victoria R. Cornelius and James R. Carpenter

    Citation: BMC Medical Research Methodology 2020 20:208

    Content type: Research article

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  27. Three-level data arising from repeated measures on individuals who are clustered within larger units are common in health research studies. Missing data are prominent in such longitudinal studies and multiple ...

    Authors: Rushani Wijesuriya, Margarita Moreno-Betancur, John B. Carlin and Katherine J. Lee

    Citation: BMC Medical Research Methodology 2020 20:207

    Content type: Research article

    Published on:

  28. The clinical progress of patients hospitalized due to COVID-19 is often associated with severe pneumonia which may require intensive care, invasive ventilation, or extracorporeal membrane oxygenation (ECMO). T...

    Authors: Derek Hazard, Klaus Kaier, Maja von Cube, Marlon Grodd, Lars Bugiera, Jerome Lambert and Martin Wolkewitz

    Citation: BMC Medical Research Methodology 2020 20:206

    Content type: Research article

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  29. Recruitment of adolescents to intervention studies is a known challenge. For randomized controlled trials (RCT) to be generalizable, reach must be assessed, which means ascertaining how many of the intended po...

    Authors: Markus Saarijärvi, Lars Wallin, Philip Moons, Hanna Gyllensten and Ewa-Lena Bratt

    Citation: BMC Medical Research Methodology 2020 20:205

    Content type: Research article

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  30. In the presence of dependent censoring even after stratification of baseline covariates, the Kaplan–Meier estimator provides an inconsistent estimate of risk. To account for dependent censoring, time-varying c...

    Authors: Takuya Kawahara, Tomohiro Shinozaki and Yutaka Matsuyama

    Citation: BMC Medical Research Methodology 2020 20:204

    Content type: Research article

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  31. Psychological safety is a dynamic team-level phenomenon which exists when team members believe that it is safe to take interpersonal risks. In healthcare teams, the presence of psychological safety is critical...

    Authors: Róisín O’Donovan, Desirée Van Dun and Eilish McAuliffe

    Citation: BMC Medical Research Methodology 2020 20:203

    Content type: Research article

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  32. Longitudinal cohort studies have made significant contributions to medical discoveries and provide the impetus for health interventions which reduce the risk of disease. Establishing and maintaining these coho...

    Authors: Leesa Costello, Julie Dare, Manon Dontje and Leon Straker

    Citation: BMC Medical Research Methodology 2020 20:202

    Content type: Research article

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  33. Social media has changed the way surgeons communicate worldwide, particularly in dissemination of trial results. However, it is unclear if social media could be used in recruitment to surgical trials. This stu...

    Authors: Carly Nichola Bisset, Ben Carter, Jennifer Law, Jonathan Hewitt, Kat Parmar and Susan Joan Moug

    Citation: BMC Medical Research Methodology 2020 20:201

    Content type: Research article

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  34. While conducting systemic reviews, searching for ongoing or unpublished trials is critical to address publication bias. As of April 2019, records of ongoing or unpublished randomized and/or quasi-randomized co...

    Authors: Masahiro Banno, Yasushi Tsujimoto and Yuki Kataoka

    Citation: BMC Medical Research Methodology 2020 20:200

    Content type: Research article

    Published on:

  35. Missing data are common in statistical analyses, and imputation methods based on random forests (RF) are becoming popular for handling missing data especially in biomedical research. Unlike standard imputation...

    Authors: Shangzhi Hong and Henry S. Lynn

    Citation: BMC Medical Research Methodology 2020 20:199

    Content type: Research article

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  36. Randomised controlled trials (RCTs) are the gold standard for evidence-based practice. However, RCTs can have limitations. For example, translation of findings into practice can be limited by design features, ...

    Authors: Agnieszka Lemanska, Rachel C. Byford, Clare Cruickshank, David P. Dearnaley, Filipa Ferreira, Clare Griffin, Emma Hall, William Hinton, Simon de Lusignan, Julian Sherlock and Sara Faithfull

    Citation: BMC Medical Research Methodology 2020 20:198

    Content type: Research article

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  37. Under competing risks, the commonly used sub-distribution hazard ratio (SHR) is not easy to interpret clinically and is valid only under the proportional sub-distribution hazard (SDH) assumption. This paper intro...

    Authors: Jingjing Lyu, Yawen Hou and Zheng Chen

    Citation: BMC Medical Research Methodology 2020 20:197

    Content type: Research article

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  38. The number of confirmed COVID-19 cases divided by population size is used as a coarse measurement for the burden of disease in a population. However, this fraction depends heavily on the sampling intensity and...

    Authors: Ola Brynildsrud

    Citation: BMC Medical Research Methodology 2020 20:196

    Content type: Research article

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  39. Controlling unobserved confounding still remains a great challenge in observational studies, and a series of strict assumptions of the existing methods usually may be violated in practice. Therefore, it is urg...

    Authors: Lu Liu, Lei Hou, Yuanyuan Yu, Xinhui Liu, Xiaoru Sun, Fan Yang, Qing Wang, Ming Jing, Yeping Xu, Hongkai Li and Fuzhong Xue

    Citation: BMC Medical Research Methodology 2020 20:195

    Content type: Technical advance

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  41. Two-dimensional personalized medicine (2-PM) models are tools for measuring individual benefits of medical treatments for chronic diseases which have potential applications in personalized medicine. These mode...

    Authors: Zhiwen Wang and Francisco J. Diaz

    Citation: BMC Medical Research Methodology 2020 20:193

    Content type: Research article

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  42. Although the WHO Trial Registration Data Set (TRDS) has been published for many years, the quality of clinical trial registrations with traditional Chinese medicine (TCM) is still not satisfactory, especially ...

    Authors: Xuan Zhang, Liang Lan, Jacky C. P. Chan, Linda L. D. Zhong, Chung-Wah Cheng, Wai-Ching Lam, Ran Tian, Chen Zhao, Tai-Xiang Wu, Hong-Cai Shang, Ai-Ping Lyu and Zhao-Xiang Bian

    Citation: BMC Medical Research Methodology 2020 20:192

    Content type: Research article

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  43. Vaccine clinical studies typically provide time-resolved data on adaptive response read-outs in response to the administration of that particular vaccine to a cohort of individuals. However, modeling such data...

    Authors: Dicle Hasdemir, Robert A. van den Berg, Antoine van Kampen and Age K. Smilde

    Citation: BMC Medical Research Methodology 2020 20:191

    Content type: Research article

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  44. In pairwise meta-analysis, the contribution of each study to the pooled estimate is given by its weight, which is based on the inverse variance of the estimate from that study. For network meta-analysis (NMA),...

    Authors: Gerta Rücker, Adriani Nikolakopoulou, Theodoros Papakonstantinou, Georgia Salanti, Richard D. Riley and Guido Schwarzer

    Citation: BMC Medical Research Methodology 2020 20:190

    Content type: Research article

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  45. Most researchers in Uzbekistan prefer to publish their reports in journals of their home country. Moreover, the proportion of healthcare practitioners who prefer to use these national sources of information al...

    Authors: Timur Aripov, Dilfuza Aniyozova and Irina Gorbunova

    Citation: BMC Medical Research Methodology 2020 20:189

    Content type: Research article

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  46. Evaluating women’s satisfaction should reflect the entire maternity care experience (antenatal, intrapartum and postnatal). The Women’s Experience Maternity Care Scale (WEMCS) questionnaire enables this assess...

    Authors: L. Floris and C. de Labrusse

    Citation: BMC Medical Research Methodology 2020 20:188

    Content type: Research article

    Published on:

  47. With declining response proportions in population-based research the importance of evaluating the effectiveness of measures aimed at improving response increases. We investigated whether an additional flyer wi...

    Authors: Stefan Rach, Kathrin Günther and Birte Hadeler

    Citation: BMC Medical Research Methodology 2020 20:187

    Content type: Research article

    Published on:

  48. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Muriel Buri, Armin Curt, John Steeves and Torsten Hothorn

    Citation: BMC Medical Research Methodology 2020 20:186

    Content type: Correction

    Published on:

    The original article was published in BMC Medical Research Methodology 2020 20:104

  50. Network meta-analysis synthesises data from a number of clinical trials in order to assess the comparative efficacy of multiple healthcare interventions in similar patient populations. In situations where clin...

    Authors: Rhiannon K. Owen, Sylwia Bujkiewicz, Douglas G. Tincello and Keith R. Abrams

    Citation: BMC Medical Research Methodology 2020 20:184

    Content type: Research article

    Published on:

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