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  1. Screening for eligible patients continues to pose a great challenge for many clinical trials. This has led to a rapidly growing interest in standardizing computable representations of eligibility criteria (EC)...

    Authors: Ahmed Rafee, Sarah Riepenhausen, Philipp Neuhaus, Alexandra Meidt, Martin Dugas and Julian Varghese
    Citation: BMC Medical Research Methodology 2022 22:141
  2. Health surveys are commonly somewhat non-representative of their target population, potentially limiting the generalisability of prevalence estimates for health/behaviour characteristics and disease to the pop...

    Authors: Sarsha Yap, Qingwei Luo, Stephen Wade, Marianne Weber, Emily Banks, Karen Canfell, Dianne L. O’Connell and Julia Steinberg
    Citation: BMC Medical Research Methodology 2022 22:140
  3. Social media has led to fundamental changes in the way that people look for and share health related information. There is increasing interest in using this spontaneously generated patient experience data as a...

    Authors: Julia Walsh, Christine Dwumfour, Jonathan Cave and Frances Griffiths
    Citation: BMC Medical Research Methodology 2022 22:139
  4. Stigmatized behaviours are often underreported, especially in pregnancy, making them challenging to address. The Alcohol and Child Development Study (ACDS) seeks to inform prevention of foetal alcohol harm, li...

    Authors: David Tappin, Daniel Mackay, Lucy Reynolds and Niamh Fitzgerald
    Citation: BMC Medical Research Methodology 2022 22:138
  5. With the spread of COVID-19, the time-series prediction of COVID-19 has become a research hotspot. Unlike previous epidemics, COVID-19 has a new pattern of long-time series, large fluctuations, and multiple pe...

    Authors: Haoran Dai, Wen Cao, Xiaochong Tong, Yunxing Yao, Feilin Peng, Jingwen Zhu and Yuzhen Tian
    Citation: BMC Medical Research Methodology 2022 22:137
  6. Manually extracted data points from health records are collated on an institutional, provincial, and national level to facilitate clinical research. However, the labour-intensive clinical chart review process ...

    Authors: Yifu Chen, Lucy Hao, Vito Z. Zou, Zsuzsanna Hollander, Raymond T. Ng and Kathryn V. Isaac
    Citation: BMC Medical Research Methodology 2022 22:136
  7. Valid and reliable research tools to assess children’s and adolescent’s health-related behaviour are highly needed across the globe. Rapid economic development, globalization, and associated lifestyle challeng...

    Authors: Jaroslav Kohoutek, Marek Maráček, Kwok Ng and Zdenek Hamrik
    Citation: BMC Medical Research Methodology 2022 22:135
  8. Guideline adaptation provides an important alternative to de novo guideline development by making the process more efficient and reducing unnecessary duplication. The quality evaluation of international guidel...

    Authors: Daniela D’angelo, Daniela Coclite, Antonello Napoletano, Silvia Gianola, Greta Castellini, Roberto Latina, Laura Iacorossi, Alice Josephine Fauci and Primiano Iannone
    Citation: BMC Medical Research Methodology 2022 22:134
  9. Prior work has shown that combining bootstrap imputation with tree-based machine learning variable selection methods can provide good performances achievable on fully observed data when covariate and outcome d...

    Authors: Jung-Yi Joyce Lin, Liangyuan Hu, Chuyue Huang, Ji Jiayi, Steven Lawrence and Usha Govindarajulu
    Citation: BMC Medical Research Methodology 2022 22:132
  10. A relative survival approach is often used in population-based cancer studies, where other cause (or expected) mortality is assumed to be the same as the mortality in the general population, given a specific c...

    Authors: Yuliya Leontyeva, Hannah Bower, Oskar Gauffin, Paul C Lambert and Therese M.-L. Andersson
    Citation: BMC Medical Research Methodology 2022 22:130
  11. Many clinical trial procedures were often undertaken in-person prior to the COVID-19 pandemic, which has resulted in adaptations to these procedures to enable trials to continue. The aim of this study was to u...

    Authors: Robin Chatters, Cindy L. Cooper, Alicia O’Cathain, Caroline Murphy, Athene Lane, Katie Sutherland, Christopher Burton, Angela Cape and Louis Tunnicliffe
    Citation: BMC Medical Research Methodology 2022 22:128
  12. The Numerical Rating Scale (NRS) and Patient-rated wrist/hand evaluation (PRWHE) are patient-reported outcomes frequently used for evaluating pain and function of the wrist and hand. The aim of this study was ...

    Authors: Susanna Stjernberg-Salmela, Teemu Karjalainen, Joona Juurakko, Pirjo Toivonen, Eero Waris, Simo Taimela, Clare L. Ardern, Teppo L. N. Järvinen and Jarkko Jokihaara
    Citation: BMC Medical Research Methodology 2022 22:127
  13. Prediction and classification algorithms are commonly used in clinical research for identifying patients susceptible to clinical conditions such as diabetes, colon cancer, and Alzheimer’s disease. Developing a...

    Authors: Arinjita Bhattacharyya, Subhadip Pal, Riten Mitra and Shesh Rai
    Citation: BMC Medical Research Methodology 2022 22:126
  14. The health crisis resulting from the global COVID-19 pandemic highlighted more than ever the need for rapid, reliable and safe methods of diagnosis and monitoring of respiratory diseases. To study pulmonary in...

    Authors: Lorena Álvarez-Rodríguez, Joaquim de Moura, Jorge Novo and Marcos Ortega
    Citation: BMC Medical Research Methodology 2022 22:125
  15. The growing volume of health data provides new opportunities for medical research. By using existing registries, large populations can be studied over a long period of time. Patient-level linkage of registries...

    Authors: Marianne J. Heins, Kelly M. de Ligt, Janneke Verloop, Sabine Siesling and Joke C. Korevaar
    Citation: BMC Medical Research Methodology 2022 22:124
  16. There are currently no methodological studies on the performance of the statistical models for estimating intervention effects based on the time-to-recurrent-event (TTRE) in stepped wedge cluster randomised tr...

    Authors: Shunsuke Oyamada, Shih-Wei Chiu and Takuhiro Yamaguchi
    Citation: BMC Medical Research Methodology 2022 22:123
  17. Missing data are common in longitudinal studies, and more so, in studies of older adults, who are susceptible to health and functional decline that limit completion of assessments. We assessed the extent, curr...

    Authors: Chinenye Okpara, Chidozie Edokwe, George Ioannidis, Alexandra Papaioannou, Jonathan D. Adachi and Lehana Thabane
    Citation: BMC Medical Research Methodology 2022 22:122
  18. Instrumental variable (IV) analysis holds the potential to estimate treatment effects from observational data. IV analysis potentially circumvents unmeasured confounding but makes a number of assumptions, such...

    Authors: I. E. Ceyisakar, N. van Leeuwen, E. W. Steyerberg and H. F. Lingsma
    Citation: BMC Medical Research Methodology 2022 22:121
  19. It is often challenging to determine which variables need to be included in the g-computation algorithm under the time-varying setting. Conditioning on instrumental variables (IVs) is known to introduce greate...

    Authors: Kosuke Inoue, Atsushi Goto, Naoki Kondo and Tomohiro Shinozaki
    Citation: BMC Medical Research Methodology 2022 22:120
  20. With the increasing use of mobile technology, ecological momentary assessments (EMAs) may enable routine monitoring of patient health outcomes and patient experiences of care by health agencies. This rapid rev...

    Authors: Rebecca J. Mitchell, Rory Goggins and Reidar P. Lystad
    Citation: BMC Medical Research Methodology 2022 22:119
  21. The COVID-19 pandemic has led to a high interest in mathematical models describing and predicting the diverse aspects and implications of the virus outbreak. Model results represent an important part of the in...

    Authors: Lukas Refisch, Fabian Lorenz, Torsten Riedlinger, Hannes Taubenböck, Martina Fischer, Linus Grabenhenrich, Martin Wolkewitz, Harald Binder and Clemens Kreutz
    Citation: BMC Medical Research Methodology 2022 22:116
  22. Stepped wedge trials are an appealing and potentially powerful cluster randomized trial design. However, they are frequently implemented with a small number of clusters. Standard analysis methods for these tri...

    Authors: Kelsey L. Grantham, Jessica Kasza, Stephane Heritier, John B. Carlin and Andrew B. Forbes
    Citation: BMC Medical Research Methodology 2022 22:112
  23. Cluster randomised trials often randomise a small number of units, putting them at risk of poor balance of covariates across treatment arms. Covariate constrained randomisation aims to reduce this risk by remo...

    Authors: Caroline Kristunas, Michael Grayling, Laura J. Gray and Karla Hemming
    Citation: BMC Medical Research Methodology 2022 22:111
  24. Systematic reviews of in-vitro studies, like any other study, can be of heterogeneous quality. The present study aimed to evaluate the methodological quality of systematic reviews of in-vitro dental studies.

    Authors: Christopher Hammel, Nikolaos Pandis, Dawid Pieper and Clovis Mariano Faggion Jr
    Citation: BMC Medical Research Methodology 2022 22:110
  25. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Georgia B. Black, Sandra van Os, Samantha Machen and Naomi J. Fulop
    Citation: BMC Medical Research Methodology 2022 22:109

    The original article was published in BMC Medical Research Methodology 2021 21:274

  26. Smoking remains a leading cause of disease burden globally. Declining youth smoking prevalence is an essential feature of effective tobacco control; however, accurate data are required to assess progress. This...

    Authors: Eden M. Barrett, Raglan Maddox, Joanne Thandrayen, Emily Banks, Raymond Lovett, Christina Heris and Katherine A. Thurber
    Citation: BMC Medical Research Methodology 2022 22:108
  27. Systematic reviews (SRs) are valuable resources as they address specific clinical questions by summarizing all existing relevant studies. However, finding all information to include in systematic reviews can b...

    Authors: Elena Stallings, Andrea Gaetano-Gil, Noelia Alvarez-Diaz, Ivan Solà, Jesús López-Alcalde, Daniel Molano and Javier Zamora
    Citation: BMC Medical Research Methodology 2022 22:107
  28. Our study aimed to compare the reference distributions of serum creatinine and urea obtained by direct sampling technique and two indirect sampling techniques including the Gaussian Mixture Model (GMM) and the...

    Authors: Ruohua Yan, Kun Li, Yaqi Lv, Yaguang Peng, Nicholas Van Halm-Lutterodt, Wenqi Song, Xiaoxia Peng and Xin Ni
    Citation: BMC Medical Research Methodology 2022 22:106
  29. Over the last years, the number of systematic reviews published is steadily increasing due to the global interest in this type of evidence synthesis. However, little is known about the characteristics of this ...

    Authors: Luísa Prada, Ana Prada, Miguel Marques Antunes, Ricardo M. Fernandes, João Costa, Joaquim J. Ferreira and Daniel Caldeira
    Citation: BMC Medical Research Methodology 2022 22:105
  30. In 2007, AMSTAR (A MeaSurement Tool to Assess systematic Reviews), a critical appraisal tool for systematic reviews (SRs), was published, and it has since become one of the most widely used instruments for SR ...

    Authors: Ruzica Bojcic, Mate Todoric and Livia Puljak
    Citation: BMC Medical Research Methodology 2022 22:104
  31. Various statistical approaches can be used to deal with unmeasured confounding when estimating treatment effects in observational studies, each with its own pros and cons. This study aimed to compare treatment...

    Authors: Marzyeh Amini, Nikki van Leeuwen, Frank Eijkenaar, Rob van de Graaf, Noor Samuels, Robert van Oostenbrugge, Ido R. van den Wijngaard, Pieter Jan van Doormaal, Yvo B. W. E. M. Roos, Charles Majoie, Bob Roozenbeek, Diederik Dippel, James Burke and Hester F. Lingsma
    Citation: BMC Medical Research Methodology 2022 22:103
  32. Early rehabilitation is the foundation for recovery for those admitted to an intensive care unit. Appropriate assessment of consciousness is needed before any rehabilitative intervention begins.

    Authors: Xiaoxiang Yan, Lingjun Xiao, Meixin Liao, Jiajian Huang, Zhijie He and Tiebin Yan
    Citation: BMC Medical Research Methodology 2022 22:102
  33. Describe and evaluate the methodological conduct of prognostic prediction models developed using machine learning methods in oncology.

    Authors: Paula Dhiman, Jie Ma, Constanza L. Andaur Navarro, Benjamin Speich, Garrett Bullock, Johanna A. A. Damen, Lotty Hooft, Shona Kirtley, Richard D. Riley, Ben Van Calster, Karel G. M. Moons and Gary S. Collins
    Citation: BMC Medical Research Methodology 2022 22:101
  34. Internal and external validity are the most relevant components when critically appraising randomized controlled trials (RCTs) for systematic reviews. However, there is no gold standard to assess external vali...

    Authors: Andres Jung, Julia Balzer, Tobias Braun and Kerstin Luedtke
    Citation: BMC Medical Research Methodology 2022 22:100
  35. In clinical trials, there is considerable interest in investigating whether a treatment effect is similar in all patients, or that one or more prognostic variables indicate a differential response to treatment...

    Authors: Willi Sauerbrei and Patrick Royston
    Citation: BMC Medical Research Methodology 2022 22:98
  36. The present study examines the psychometric properties of the German adaptation of the Client Attachment to Therapist Scale (CATS). The validity of the scale as originally proposed has recently been brought in...

    Authors: Katja Petrowski, Bjarne Schmalbach, Joram Ronel, Ileana Schmalbach and Elisabeth Olliges
    Citation: BMC Medical Research Methodology 2022 22:96
  37. Cancer survival represents one of the main indicators of interest in cancer epidemiology. However, the survival of cancer patients can be affected by several factors, such as comorbidities, that may interact w...

    Authors: Francisco Javier Rubio, Danilo Alvares, Daniel Redondo-Sanchez, Rafael Marcos-Gragera, María-José Sánchez and Miguel Angel Luque-Fernandez
    Citation: BMC Medical Research Methodology 2022 22:95
  38. Over the last two decades, telephone surveys based on random digit dialing have developed considerably. At the same time, however, the proportion of the population with a cell phone has increased, whereas land...

    Authors: Noémie Soullier, Stéphane Legleye and Jean-Baptiste Richard
    Citation: BMC Medical Research Methodology 2022 22:94
  39. Data from certain subgroups of clinical interest may not be presented in primary manuscripts or conference abstract presentations. In an effort to enable secondary data analyses, we propose a workflow to retri...

    Authors: Joseph J. Zhao, Nicholas L. Syn, Benjamin Kye Jyn Tan, Dominic Wei Ting Yap, Chong Boon Teo, Yiong Huak Chan and Raghav Sundar
    Citation: BMC Medical Research Methodology 2022 22:93
  40. Although standardized measures to assess substance use are available, most studies use variations of these measures making it challenging to harmonize data across studies. The aim of this study was to evaluate...

    Authors: Marjan Javanbakht, Johnny Lin, Amy Ragsdale, Soyeon Kim, Suzanne Siminski and Pamina Gorbach
    Citation: BMC Medical Research Methodology 2022 22:90

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