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  1. Although randomized trials and systematic reviews provide the best evidence to guide medical practice, many permanent neonatal diabetes mellitus (PNDM) studies have been published as case reports. However, the...

    Authors: Pengli Jia, Ling Wang, Xi Yang, WenTing Pei, Chang Xu, Jinglin Feng and Ying Han
    Citation: BMC Medical Research Methodology 2024 24:117
  2. Extended illness-death models (a specific class of multistate models) are a useful tool to analyse situations like hospital-acquired infections, ventilation-associated pneumonia, and transfers between hospital...

    Authors: Marlon Grodd, Susanne Weber and Martin Wolkewitz
    Citation: BMC Medical Research Methodology 2024 24:116
  3. Nested case–control (NCC) designs are efficient for developing and validating prediction models that use expensive or difficult-to-obtain predictors, especially when the outcome is rare. Previous research has ...

    Authors: Barbara Rentroia-Pacheco, Domenico Bellomo, Inge M. M. Lakeman, Marlies Wakkee, Loes M. Hollestein and David van Klaveren
    Citation: BMC Medical Research Methodology 2024 24:115
  4. Smoking is a critical risk factor responsible for over eight million annual deaths worldwide. It is essential to obtain information on smoking habits to advance research and implement preventive measures such ...

    Authors: Ali Ebrahimi, Margrethe Bang Høstgaard Henriksen, Claus Lohman Brasen, Ole Hilberg, Torben Frøstrup Hansen, Lars Henrik Jensen, Abdolrahman Peimankar and Uffe Kock Wiil
    Citation: BMC Medical Research Methodology 2024 24:114
  5. Health administrative databases play a crucial role in population-level multimorbidity surveillance. Determining the appropriate retrospective or lookback period (LP) for observing prevalent and newly diagnose...

    Authors: Marc Simard, Elham Rahme, Marjolaine Dubé, Véronique Boiteau, Denis Talbot and Caroline Sirois
    Citation: BMC Medical Research Methodology 2024 24:113
  6. Orphan diseases, exemplified by T-cell prolymphocytic leukemia, present inherent challenges due to limited data availability and complexities in effective care. This study delves into harnessing the potential ...

    Authors: Gunjan Chandra, Junfeng Wang, Pekka Siirtola and Juha Röning
    Citation: BMC Medical Research Methodology 2024 24:112
  7. A Generalized Linear Mixed Model (GLMM) is recommended to meta-analyze diagnostic test accuracy studies (DTAs) based on aggregate or individual participant data. Since a GLMM does not have a closed-form likeli...

    Authors: Yixin Zhao, Bilal Khan and Zelalem F. Negeri
    Citation: BMC Medical Research Methodology 2024 24:111
  8. Systematic literature reviews (SLRs) are critical for life-science research. However, the manual selection and retrieval of relevant publications can be a time-consuming process. This study aims to (1) develop...

    Authors: Jingcheng Du, Ekin Soysal, Dong Wang, Long He, Bin Lin, Jingqi Wang, Frank J. Manion, Yeran Li, Elise Wu and Lixia Yao
    Citation: BMC Medical Research Methodology 2024 24:108
  9. Semiparametric survival analysis such as the Cox proportional hazards (CPH) regression model is commonly employed in endometrial cancer (EC) study. Although this method does not need to know the baseline hazar...

    Authors: Xingfeng Li, Diana Marcus, James Russell, Eric O. Aboagye, Laura Burney Ellis, Alexander Sheeka, Won-Ho Edward Park, Nishat Bharwani, Sadaf Ghaem-Maghami and Andrea G. Rockall
    Citation: BMC Medical Research Methodology 2024 24:107
  10. During the COVID-19 pandemic, many intensive care units (ICUs) halted research to focus on COVID-19-specific studies.

    Authors: Brittany Dennis, Adam Deane, François Lauzier, Nicole Zytaruk, Miranda Hardie, Naomi Hammond, Simon Finfer, Yaseen Arabi, John Marshall, Lois Saunders, Diane Heels-Ansdell, John Myburgh, Serena Knowles, John Muscedere, Marlies Ostermann, Dorrilyn Rajbhandari…
    Citation: BMC Medical Research Methodology 2024 24:109
  11. Survival prediction using high-dimensional molecular data is a hot topic in the field of genomics and precision medicine, especially for cancer studies. Considering that carcinogenesis has a pathway-based path...

    Authors: Junjie Shen, Shuo Wang, Hao Sun, Jie Huang, Lu Bai, Xichao Wang, Yongfei Dong and Zaixiang Tang
    Citation: BMC Medical Research Methodology 2024 24:105
  12. Patient-Reported Outcome Measures (PROM) provide important information, however, missing PROM data threaten the interpretability and generalizability of findings by introducing potential bias. This study aims ...

    Authors: Johanne Dam Lyhne, Allan ‘Ben’ Smith, Lars Henrik Jensen, Torben Frøstrup Hansen, Lisbeth Frostholm and Signe Timm
    Citation: BMC Medical Research Methodology 2024 24:104
  13. Use of participatory research methods is increasing in research trials. Once partnerships are established with end-users, there is less guidance about processes research teams can use to successfully incorpora...

    Authors: Princess E. Ackland, Hildi J. Hagedorn, Marie E. Kenny, Hope A. Salameh, Shannon M. Kehle-Forbes, Allison M. Gustavson, Leyla E. Karimzadeh and Laura A. Meis
    Citation: BMC Medical Research Methodology 2024 24:103
  14. Multiple myeloma (MM) is the second most common haematological cancer worldwide. Along with related diseases including monoclonal gammopathy of undetermined significance (MGUS), plasma cell leukaemia (PCL) and...

    Authors: Naomi Aoki, Pin-Yen Chen, Wenming Chen, Wee Joo Chng, Gin Gin Gan, Yeow Tee Goh, Jian Hou, Jeffrey Huang, Kihyun Kim, Je Jung Lee, Jin Lu, Zoe K. McQuilten, Chang Ki Min, Elizabeth Moore, Laura Oliver, Neil A. Waters…
    Citation: BMC Medical Research Methodology 2024 24:102
  15. Vaccine efficacy (VE) assessed in a randomized controlled clinical trial can be affected by demographic, clinical, and other subject-specific characteristics evaluated as baseline covariates. Understanding the...

    Authors: Julie Dudášová, Zdeněk Valenta and Jeffrey R. Sachs
    Citation: BMC Medical Research Methodology 2024 24:101
  16. In the literature, the propriety of the meta-analytic treatment-effect produced by combining randomized controlled trials (RCT) and non-randomized studies (NRS) is questioned, given the inherent confounding in...

    Authors: John L. Moran and Ariel Linden
    Citation: BMC Medical Research Methodology 2024 24:99
  17. Language barriers can impact health care and outcomes. Valid and reliable language data is central to studying health inequalities in linguistic minorities. In Canada, language variables are available in admin...

    Authors: Ricardo Batista, Amy T. Hsu, Louise Bouchard, Michael Reaume, Emily Rhodes, Ewa Sucha, Eva Guerin, Denis Prud’homme, Douglas G. Manuel and Peter Tanuseputro
    Citation: BMC Medical Research Methodology 2024 24:98
  18. One of the most common causes of death worldwide is heart disease, including arrhythmia. Today, sciences such as artificial intelligence and medical statistics are looking for methods and models for correct an...

    Authors: Bahare Andayeshgar, Fardin Abdali-Mohammadi, Majid Sepahvand, Afshin Almasi and Nader Salari
    Citation: BMC Medical Research Methodology 2024 24:96
  19. Multimorbidity is typically associated with deficient health-related quality of life in mid-life, and the likelihood of developing multimorbidity in women is elevated. We address the issue of data sparsity in ...

    Authors: Dayana Benny, Mario Giacobini, Giuseppe Costa, Roberto Gnavi and Fulvio Ricceri
    Citation: BMC Medical Research Methodology 2024 24:95
  20. Accurate prevalence estimates of drug use and its harms are important to characterize burden and develop interventions to reduce negative health outcomes and disparities. Lack of a sampling frame for marginali...

    Authors: Abby E. Rudolph, Robin M. Nance, Georgiy Bobashev, Daniel Brook, Wajiha Akhtar, Ryan Cook, Hannah L. Cooper, Peter D. Friedmann, Simon D. W. Frost, Vivian F. Go, Wiley D. Jenkins, Philip T. Korthuis, William C. Miller, Mai T. Pho, Stephanie A. Ruderman, David W. Seal…
    Citation: BMC Medical Research Methodology 2024 24:94
  21. The dissemination of clinical trial results is an important scientific and ethical endeavour. This survey of completed interventional studies in a French academic center describes their reporting status.

    Authors: Anne Sophie Alix-Doucet, Constant Vinatier, Loïc Fin, Hervé Léna, Hélène Rangé, Clara Locher and Florian Naudet
    Citation: BMC Medical Research Methodology 2024 24:93
  22. The objective of this research was to create and validate an interpretable prediction model for drug-induced liver injury (DILI) during tuberculosis (TB) treatment.

    Authors: Yue Xiao, Yanfei Chen, Ruijian Huang, Feng Jiang, Jifang Zhou and Tianchi Yang
    Citation: BMC Medical Research Methodology 2024 24:92
  23. Observational data provide invaluable real-world information in medicine, but certain methodological considerations are required to derive causal estimates. In this systematic review, we evaluated the methodol...

    Authors: Heather Hufstedler, Nicole Mauer, Edmund Yeboah, Sinclair Carr, Sabahat Rahman, Alexander M. Danzer, Thomas P. A. Debray, Valentijn M.T. de Jong, Harlan Campbell, Paul Gustafson, Lauren Maxwell, Thomas Jaenisch, Ellicott C. Matthay and Till Bärnighausen
    Citation: BMC Medical Research Methodology 2024 24:91
  24. Invasive micropapillary carcinoma (IMPC) of the breast is known for its high propensity for lymph node (LN) invasion. Inadequate LN dissection may compromise the precision of prognostic assessments. This study...

    Authors: Xiangdi Meng, Furong Hao, Nan Wang, Peiyan Qin, Zhuojun Ju and Daqing Sun
    Citation: BMC Medical Research Methodology 2024 24:90
  25. Outliers, data points that significantly deviate from the norm, can have a substantial impact on statistical inference and provide valuable insights in data analysis. Multiple methods have been developed for o...

    Authors: Jiaxin Cai, Weiwei Hu, Yuhui Yang, Hong Yan and Fangyao Chen
    Citation: BMC Medical Research Methodology 2024 24:89
  26. The analysis of dental caries has been a major focus of recent work on modeling dental defect data. While a dental caries focus is of major importance in dental research, the examination of developmental defec...

    Authors: Everette P. Keller, Andrew B. Lawson, Carol L. Wagner and Susan G. Reed
    Citation: BMC Medical Research Methodology 2024 24:88
  27. Overweight is a major risk factor for non-communicable diseases (NCDs) in Europe, affecting almost 60% of all adults. Tackling obesity is therefore a key long-term health challenge and is vital to reduce prema...

    Authors: Ingrid Pelgrims, Brecht Devleesschauwer, Stefanie Vandevijvere, Eva M. De Clercq, Johan Van der Heyden and Stijn Vansteelandt
    Citation: BMC Medical Research Methodology 2024 24:87
  28. Prostate cancer is the most common cancer after non-melanoma skin cancer and the second leading cause of cancer deaths in US men. Its incidence and mortality rates vary substantially across geographical region...

    Authors: Ming Wang, Zheng Li, Jun Lu, Lijun Zhang, Yimei Li and Liangliang Zhang
    Citation: BMC Medical Research Methodology 2024 24:86
  29. Recruiting participants to clinical trials is an ongoing challenge, and relatively little is known about what recruitment strategies lead to better recruitment. Recruitment interventions can be considered comp...

    Authors: Natasha Hudek, Kelly Carroll, Seana Semchishen, Shelley Vanderhout, Justin Presseau, Jeremy Grimshaw, Dean A. Fergusson, Katie Gillies, Ian D. Graham, Monica Taljaard and Jamie C. Brehaut
    Citation: BMC Medical Research Methodology 2024 24:85
  30. An important application of ROC analysis is the determination of the optimal cut-point for biomarkers in diagnostic studies. This comprehensive review provides a framework of cut-point election for biomarkers ...

    Authors: Mojtaba Hassanzad and Karimollah Hajian-Tilaki
    Citation: BMC Medical Research Methodology 2024 24:84
  31. The timing of treating cancer patients is an essential factor in the efficacy of treatment. So, patients who will not respond to current therapy should receive a different treatment as early as possible. Machi...

    Authors: Elham Majd, Li Xing and Xuekui Zhang
    Citation: BMC Medical Research Methodology 2024 24:83
  32. This retrospective analysis aimed to comprehensively review the design and regulatory aspects of bioequivalence trials submitted to the Saudi Food and Drug Authority (SFDA) since 2017.

    Authors: Turki A. Althunian, Bader R. Alzenaidy, Raseel A. Alroba, Ohoud A. Almadani, Fahad A. Alqahtani, Albatool A. Binajlan, Amal I. Almousa, Deema K. Alamr, Malak S. Al-Mofada, Nora Y. Alsaqer, Hessa A. Alarfaj, Abdulmohsen A. Bahlewa, Mohammed A. Alharbi, Ali M. Alhomaidan, Abdulaziz A. Alsuwyeh and Abdulmohsen A. Alsaleh
    Citation: BMC Medical Research Methodology 2024 24:82
  33. Epidemiological studies in refugee settings are often challenged by the denominator problem, i.e. lack of population at risk data. We develop an empirical approach to address this problem by assessing relation...

    Authors: Stella Erdmann, Rosa Jahn, Sven Rohleder and Kayvan Bozorgmehr
    Citation: BMC Medical Research Methodology 2024 24:81
  34. Group sequential designs incorporating the option to stop for futility at the time point of an interim analysis can save time and resources. Thereby, the choice of the futility boundary importantly impacts the...

    Authors: Michaela Maria Freitag, Xieran Li and Geraldine Rauch
    Citation: BMC Medical Research Methodology 2024 24:80
  35. The screening process for systematic reviews and meta-analyses in medical research is a labor-intensive and time-consuming task. While machine learning and deep learning have been applied to facilitate this pr...

    Authors: Mahbod Issaiy, Hossein Ghanaati, Shahriar Kolahi, Madjid Shakiba, Amir Hossein Jalali, Diana Zarei, Sina Kazemian, Mahsa Alborzi Avanaki and Kavous Firouznia
    Citation: BMC Medical Research Methodology 2024 24:78
  36. SARS-CoV-2 vaccines are effective in reducing hospitalization, COVID-19 symptoms, and COVID-19 mortality for nursing home (NH) residents. We sought to compare the accuracy of various machine learning models, e...

    Authors: Komal Aryal, Fabrice I. Mowbray, Anna Miroshnychenko, Ryan P. Strum, Darly Dash, Michael P. Hillmer, Kamil Malikov, Andrew P. Costa and Aaron Jones
    Citation: BMC Medical Research Methodology 2024 24:77
  37. Legal requirements, certification specifications, as well as the demand for real world data on cancer research and treatment led to the decision to establish the University Clinical Cancer Registry Regensburg....

    Authors: Anna Saibold, Michael Koller, Karolina Mueller, Oliver Koelbl, Veronika Vielsmeier, Tobias Pukrop, Oliver Spies, Vivian Eilers, Cathleen Brese, Denise Amann and Julia Maurer
    Citation: BMC Medical Research Methodology 2024 24:76
  38. Diabetes is one of the top four non-communicable diseases that cause death and illness to many people around the world. This study aims to use an efficient count data model to estimate socio-environmental fact...

    Authors: Sauda Hatibu Mbwambo, Maurice C. Mbago and Gadde Srinivasa Rao
    Citation: BMC Medical Research Methodology 2024 24:75
  39. One key aspect of personalized medicine is to identify individuals who benefit from an intervention. Some approaches have been developed to estimate individualized treatment effects (ITE) with a single randomi...

    Authors: Florie Bouvier, Anna Chaimani, Etienne Peyrot, François Gueyffier, Guillaume Grenet and Raphaël Porcher
    Citation: BMC Medical Research Methodology 2024 24:74
  40. Misclassification bias (MB) is the deviation of measured from true values due to incorrect case assignment. This study compared MB when cystectomy status was determined using administrative database codes vs. ...

    Authors: James Ross, Luke T. Lavallee, Duane Hickling and Carl van Walraven
    Citation: BMC Medical Research Methodology 2024 24:73
  41. In the causal mediation analysis framework, several parametric regression-based approaches have been introduced in past years for decomposing the total effect of an exposure on a binary outcome into a direct e...

    Authors: Miguel Caubet, Kevin L’Espérance, Anita Koushik and Geneviève Lefebvre
    Citation: BMC Medical Research Methodology 2024 24:72
  42. Patients with multiple conditions present a growing challenge for healthcare provision. Measures of multimorbidity may support clinical management, healthcare resource allocation and accounting for the health ...

    Authors: Hannah Harrison, Samantha Ip, Cristina Renzi, Yangfan Li, Matthew Barclay, Juliet Usher-Smith, Georgios Lyratzopoulos, Angela Wood and Antonis C. Antoniou
    Citation: BMC Medical Research Methodology 2024 24:71
  43. Intensive longitudinal data (ILD) collected in near real time by mobile health devices provide a new opportunity for monitoring chronic diseases, early disease risk prediction, and disease prevention in health...

    Authors: Qing Yang, Meilin Jiang, Cai Li, Sheng Luo, Matthew J. Crowley and Ryan J. Shaw
    Citation: BMC Medical Research Methodology 2024 24:69
  44. The challenging nature of studies with incarcerated populations and other offender groups can impede the conduct of research, particularly that involving complex study designs such as randomised control trials...

    Authors: George Karystianis, Wilson Lukmanjaya, Iain Buchan, Paul Simpson, Natasha Ginnivan, Goran Nenadic and Tony Butler
    Citation: BMC Medical Research Methodology 2024 24:68

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