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  1. Causal mediation analysis plays a crucial role in examining causal effects and causal mechanisms. Yet, limited work has taken into consideration the use of sampling weights in causal mediation analysis. In thi...

    Authors: Donna L. Coffman, Haoyu Zhou, Katherine E. Castellano, Megan S. Schuler and Daniel F. McCaffrey
    Citation: BMC Medical Research Methodology 2024 24:133
  2. Accelerometers, devices that measure body movements, have become valuable tools for studying the fragmentation of rest-activity patterns, a core circadian rhythm dimension, using metrics such as inter-daily st...

    Authors: Ian Meneghel Danilevicz, Vincent Theodoor van Hees, Frank C. T. van der Heide, Louis Jacob, Benjamin Landré, Mohamed Amine Benadjaoud and Séverine Sabia
    Citation: BMC Medical Research Methodology 2024 24:132
  3. Dynamical mathematical models defined by a system of differential equations are typically not easily accessible to non-experts. However, forecasts based on these types of models can help gain insights into the...

    Authors: Gerardo Chowell, Amna Tariq, Sushma Dahal, Amanda Bleichrodt, Ruiyan Luo and James M. Hyman
    Citation: BMC Medical Research Methodology 2024 24:131
  4. Faced with the high cost and limited efficiency of classical randomized controlled trials, researchers are increasingly applying adaptive designs to speed up the development of new drugs. However, the applicat...

    Authors: Yuning Wang, Minghong Yao, Jiali Liu, Yanmei Liu, Yu Ma, Xiaochao Luo, Fan Mei, Hunong Xiang, Kang Zou, Ling Li and Xin Sun
    Citation: BMC Medical Research Methodology 2024 24:130
  5. While clinical coding is intended to be an objective and standardized practice, it is important to recognize that it is not entirely the case. The clinical and bureaucratic practices from event of death to a c...

    Authors: Alexandria Chung, George Addo Opoku-Pare and Holly Tibble
    Citation: BMC Medical Research Methodology 2024 24:129
  6. Clinical prediction models can help identify high-risk patients and facilitate timely interventions. However, developing such models for rare diseases presents challenges due to the scarcity of affected patien...

    Authors: Pedro Cardoso, Timothy J. McDonald, Kashyap A. Patel, Ewan R. Pearson, Andrew T. Hattersley, Beverley M. Shields and Trevelyan J. McKinley
    Citation: BMC Medical Research Methodology 2024 24:128
  7. An electrocardiogram is a medical examination tool for measuring different patterns of heart blood flow circle either in the form of usual or non-invasive patterns. These patterns are useful for the identifica...

    Authors: Uzair Iqbal, Riyad Almakki, Muhammad Usman, Abdullah Altameem, Mubarak Albathan and Abdul Khader Jilani
    Citation: BMC Medical Research Methodology 2024 24:127
  8. A growing number of older adults (ages 65+) live with Type 1 diabetes. Simultaneously, technologies such as continuous glucose monitoring (CGM) have become standard of care. There is thus a need to understand ...

    Authors: Anna R. Kahkoska, Cambray Smith, Laura A. Young and Kristen Hassmiller Lich
    Citation: BMC Medical Research Methodology 2024 24:126
  9. Mediation analysis is a powerful tool to identify factors mediating the causal pathway of exposure to health outcomes. Mediation analysis has been extended to study a large number of potential mediators in hig...

    Authors: Weiwei Hu, Shiyu Chen, Jiaxin Cai, Yuhui Yang, Hong Yan and Fangyao Chen
    Citation: BMC Medical Research Methodology 2024 24:125
  10. Multi-arm multi-stage (MAMS) randomised trial designs have been proposed to evaluate multiple research questions in the confirmatory setting. In designs with several interventions, such as the 8-arm 3-stage RO...

    Authors: Babak Choodari-Oskooei, Alexandra Blenkinsop, Kelly Handley, Thomas Pinkney and Mahesh K. B. Parmar
    Citation: BMC Medical Research Methodology 2024 24:124
  11. In contemporary society, depression has emerged as a prominent mental disorder that exhibits exponential growth and exerts a substantial influence on premature mortality. Although numerous research applied mac...

    Authors: Tumpa Rani Shaha, Momotaz Begum, Jia Uddin, Vanessa Yélamos Torres, Josep Alemany Iturriaga, Imran Ashraf and Md. Abdus Samad
    Citation: BMC Medical Research Methodology 2024 24:123
  12. Two propensity score (PS) based balancing covariate methods, the overlap weighting method (OW) and the fine stratification method (FS), produce superb covariate balance. OW has been compared with various weigh...

    Authors: Wen Wan, Manoradhan Murugesan, Robert S. Nocon, Joshua Bolton, R. Tamara Konetzka, Marshall H. Chin and Elbert S. Huang
    Citation: BMC Medical Research Methodology 2024 24:122
  13. Inequities in health access and outcomes exist between Indigenous and non-Indigenous populations. Embedded pragmatic randomized, controlled trials (ePCTs) can test the real-world effectiveness of health care i...

    Authors: Joanna Hikaka, Ellen M. McCreedy, Eric Jutkowitz, Ellen P. McCarthy and Rosa R. Baier
    Citation: BMC Medical Research Methodology 2024 24:121
  14. To describe the methodology for conducting the CalScope study, a remote, population-based survey launched by the California Department of Public Health (CDPH) to estimate SARS-CoV-2 seroprevalence and understa...

    Authors: Esther Lim, Megha L. Mehrotra, Katherine Lamba, Amanda Kamali, Kristina W. Lai, Erika Meza, Stephanie Bertsch-Merbach, Irvin Szeto, Catherine Ley, Andrew B. Martin, Julie Parsonnet, Peter Robinson, David Gebhart, Noemi Fonseca, Cheng-ting Tsai, David Seftel…
    Citation: BMC Medical Research Methodology 2024 24:120
  15. Responsiveness to the population’s non-clinical needs encompasses various dimensions, including responsive research and an educational outreach plan at the community level. This study aims to develop a communi...

    Authors: Hooman Khanpoor, Mohammad Amerzadeh, Ahad Alizadeh, Omid Khosravizadeh and Sima Rafiei
    Citation: BMC Medical Research Methodology 2024 24:119
  16. Intervention fidelity in health services research has been poor with a reported lack of understanding about what constitutes pragmatic adaptation of interventions and what constitutes failure to maintain inter...

    Authors: Abigail J. Hall, Victoria A. Goodwin and David J. Clarke
    Citation: BMC Medical Research Methodology 2024 24:118
  17. Although randomized trials and systematic reviews provide the best evidence to guide medical practice, many permanent neonatal diabetes mellitus (PNDM) studies have been published as case reports. However, the...

    Authors: Pengli Jia, Ling Wang, Xi Yang, WenTing Pei, Chang Xu, Jinglin Feng and Ying Han
    Citation: BMC Medical Research Methodology 2024 24:117
  18. Extended illness-death models (a specific class of multistate models) are a useful tool to analyse situations like hospital-acquired infections, ventilation-associated pneumonia, and transfers between hospital...

    Authors: Marlon Grodd, Susanne Weber and Martin Wolkewitz
    Citation: BMC Medical Research Methodology 2024 24:116
  19. Nested case–control (NCC) designs are efficient for developing and validating prediction models that use expensive or difficult-to-obtain predictors, especially when the outcome is rare. Previous research has ...

    Authors: Barbara Rentroia-Pacheco, Domenico Bellomo, Inge M. M. Lakeman, Marlies Wakkee, Loes M. Hollestein and David van Klaveren
    Citation: BMC Medical Research Methodology 2024 24:115
  20. Smoking is a critical risk factor responsible for over eight million annual deaths worldwide. It is essential to obtain information on smoking habits to advance research and implement preventive measures such ...

    Authors: Ali Ebrahimi, Margrethe Bang Høstgaard Henriksen, Claus Lohman Brasen, Ole Hilberg, Torben Frøstrup Hansen, Lars Henrik Jensen, Abdolrahman Peimankar and Uffe Kock Wiil
    Citation: BMC Medical Research Methodology 2024 24:114
  21. Health administrative databases play a crucial role in population-level multimorbidity surveillance. Determining the appropriate retrospective or lookback period (LP) for observing prevalent and newly diagnose...

    Authors: Marc Simard, Elham Rahme, Marjolaine Dubé, Véronique Boiteau, Denis Talbot and Caroline Sirois
    Citation: BMC Medical Research Methodology 2024 24:113
  22. Orphan diseases, exemplified by T-cell prolymphocytic leukemia, present inherent challenges due to limited data availability and complexities in effective care. This study delves into harnessing the potential ...

    Authors: Gunjan Chandra, Junfeng Wang, Pekka Siirtola and Juha Röning
    Citation: BMC Medical Research Methodology 2024 24:112
  23. A Generalized Linear Mixed Model (GLMM) is recommended to meta-analyze diagnostic test accuracy studies (DTAs) based on aggregate or individual participant data. Since a GLMM does not have a closed-form likeli...

    Authors: Yixin Zhao, Bilal Khan and Zelalem F. Negeri
    Citation: BMC Medical Research Methodology 2024 24:111
  24. Systematic literature reviews (SLRs) are critical for life-science research. However, the manual selection and retrieval of relevant publications can be a time-consuming process. This study aims to (1) develop...

    Authors: Jingcheng Du, Ekin Soysal, Dong Wang, Long He, Bin Lin, Jingqi Wang, Frank J. Manion, Yeran Li, Elise Wu and Lixia Yao
    Citation: BMC Medical Research Methodology 2024 24:108
  25. Semiparametric survival analysis such as the Cox proportional hazards (CPH) regression model is commonly employed in endometrial cancer (EC) study. Although this method does not need to know the baseline hazar...

    Authors: Xingfeng Li, Diana Marcus, James Russell, Eric O. Aboagye, Laura Burney Ellis, Alexander Sheeka, Won-Ho Edward Park, Nishat Bharwani, Sadaf Ghaem-Maghami and Andrea G. Rockall
    Citation: BMC Medical Research Methodology 2024 24:107
  26. During the COVID-19 pandemic, many intensive care units (ICUs) halted research to focus on COVID-19-specific studies.

    Authors: Brittany Dennis, Adam Deane, François Lauzier, Nicole Zytaruk, Miranda Hardie, Naomi Hammond, Simon Finfer, Yaseen Arabi, John Marshall, Lois Saunders, Diane Heels-Ansdell, John Myburgh, Serena Knowles, John Muscedere, Marlies Ostermann, Dorrilyn Rajbhandari…
    Citation: BMC Medical Research Methodology 2024 24:109
  27. Survival prediction using high-dimensional molecular data is a hot topic in the field of genomics and precision medicine, especially for cancer studies. Considering that carcinogenesis has a pathway-based path...

    Authors: Junjie Shen, Shuo Wang, Hao Sun, Jie Huang, Lu Bai, Xichao Wang, Yongfei Dong and Zaixiang Tang
    Citation: BMC Medical Research Methodology 2024 24:105
  28. Patient-Reported Outcome Measures (PROM) provide important information, however, missing PROM data threaten the interpretability and generalizability of findings by introducing potential bias. This study aims ...

    Authors: Johanne Dam Lyhne, Allan ‘Ben’ Smith, Lars Henrik Jensen, Torben Frøstrup Hansen, Lisbeth Frostholm and Signe Timm
    Citation: BMC Medical Research Methodology 2024 24:104
  29. Use of participatory research methods is increasing in research trials. Once partnerships are established with end-users, there is less guidance about processes research teams can use to successfully incorpora...

    Authors: Princess E. Ackland, Hildi J. Hagedorn, Marie E. Kenny, Hope A. Salameh, Shannon M. Kehle-Forbes, Allison M. Gustavson, Leyla E. Karimzadeh and Laura A. Meis
    Citation: BMC Medical Research Methodology 2024 24:103
  30. Multiple myeloma (MM) is the second most common haematological cancer worldwide. Along with related diseases including monoclonal gammopathy of undetermined significance (MGUS), plasma cell leukaemia (PCL) and...

    Authors: Naomi Aoki, Pin-Yen Chen, Wenming Chen, Wee Joo Chng, Gin Gin Gan, Yeow Tee Goh, Jian Hou, Jeffrey Huang, Kihyun Kim, Je Jung Lee, Jin Lu, Zoe K. McQuilten, Chang Ki Min, Elizabeth Moore, Laura Oliver, Neil A. Waters…
    Citation: BMC Medical Research Methodology 2024 24:102
  31. Vaccine efficacy (VE) assessed in a randomized controlled clinical trial can be affected by demographic, clinical, and other subject-specific characteristics evaluated as baseline covariates. Understanding the...

    Authors: Julie Dudášová, Zdeněk Valenta and Jeffrey R. Sachs
    Citation: BMC Medical Research Methodology 2024 24:101
  32. In the literature, the propriety of the meta-analytic treatment-effect produced by combining randomized controlled trials (RCT) and non-randomized studies (NRS) is questioned, given the inherent confounding in...

    Authors: John L. Moran and Ariel Linden
    Citation: BMC Medical Research Methodology 2024 24:99
  33. Language barriers can impact health care and outcomes. Valid and reliable language data is central to studying health inequalities in linguistic minorities. In Canada, language variables are available in admin...

    Authors: Ricardo Batista, Amy T. Hsu, Louise Bouchard, Michael Reaume, Emily Rhodes, Ewa Sucha, Eva Guerin, Denis Prud’homme, Douglas G. Manuel and Peter Tanuseputro
    Citation: BMC Medical Research Methodology 2024 24:98
  34. One of the most common causes of death worldwide is heart disease, including arrhythmia. Today, sciences such as artificial intelligence and medical statistics are looking for methods and models for correct an...

    Authors: Bahare Andayeshgar, Fardin Abdali-Mohammadi, Majid Sepahvand, Afshin Almasi and Nader Salari
    Citation: BMC Medical Research Methodology 2024 24:96
  35. Multimorbidity is typically associated with deficient health-related quality of life in mid-life, and the likelihood of developing multimorbidity in women is elevated. We address the issue of data sparsity in ...

    Authors: Dayana Benny, Mario Giacobini, Giuseppe Costa, Roberto Gnavi and Fulvio Ricceri
    Citation: BMC Medical Research Methodology 2024 24:95
  36. Accurate prevalence estimates of drug use and its harms are important to characterize burden and develop interventions to reduce negative health outcomes and disparities. Lack of a sampling frame for marginali...

    Authors: Abby E. Rudolph, Robin M. Nance, Georgiy Bobashev, Daniel Brook, Wajiha Akhtar, Ryan Cook, Hannah L. Cooper, Peter D. Friedmann, Simon D. W. Frost, Vivian F. Go, Wiley D. Jenkins, Philip T. Korthuis, William C. Miller, Mai T. Pho, Stephanie A. Ruderman, David W. Seal…
    Citation: BMC Medical Research Methodology 2024 24:94
  37. The dissemination of clinical trial results is an important scientific and ethical endeavour. This survey of completed interventional studies in a French academic center describes their reporting status.

    Authors: Anne Sophie Alix-Doucet, Constant Vinatier, Loïc Fin, Hervé Léna, Hélène Rangé, Clara Locher and Florian Naudet
    Citation: BMC Medical Research Methodology 2024 24:93
  38. The objective of this research was to create and validate an interpretable prediction model for drug-induced liver injury (DILI) during tuberculosis (TB) treatment.

    Authors: Yue Xiao, Yanfei Chen, Ruijian Huang, Feng Jiang, Jifang Zhou and Tianchi Yang
    Citation: BMC Medical Research Methodology 2024 24:92
  39. Observational data provide invaluable real-world information in medicine, but certain methodological considerations are required to derive causal estimates. In this systematic review, we evaluated the methodol...

    Authors: Heather Hufstedler, Nicole Mauer, Edmund Yeboah, Sinclair Carr, Sabahat Rahman, Alexander M. Danzer, Thomas P. A. Debray, Valentijn M.T. de Jong, Harlan Campbell, Paul Gustafson, Lauren Maxwell, Thomas Jaenisch, Ellicott C. Matthay and Till Bärnighausen
    Citation: BMC Medical Research Methodology 2024 24:91
  40. Invasive micropapillary carcinoma (IMPC) of the breast is known for its high propensity for lymph node (LN) invasion. Inadequate LN dissection may compromise the precision of prognostic assessments. This study...

    Authors: Xiangdi Meng, Furong Hao, Nan Wang, Peiyan Qin, Zhuojun Ju and Daqing Sun
    Citation: BMC Medical Research Methodology 2024 24:90
  41. Outliers, data points that significantly deviate from the norm, can have a substantial impact on statistical inference and provide valuable insights in data analysis. Multiple methods have been developed for o...

    Authors: Jiaxin Cai, Weiwei Hu, Yuhui Yang, Hong Yan and Fangyao Chen
    Citation: BMC Medical Research Methodology 2024 24:89
  42. The analysis of dental caries has been a major focus of recent work on modeling dental defect data. While a dental caries focus is of major importance in dental research, the examination of developmental defec...

    Authors: Everette P. Keller, Andrew B. Lawson, Carol L. Wagner and Susan G. Reed
    Citation: BMC Medical Research Methodology 2024 24:88
  43. Overweight is a major risk factor for non-communicable diseases (NCDs) in Europe, affecting almost 60% of all adults. Tackling obesity is therefore a key long-term health challenge and is vital to reduce prema...

    Authors: Ingrid Pelgrims, Brecht Devleesschauwer, Stefanie Vandevijvere, Eva M. De Clercq, Johan Van der Heyden and Stijn Vansteelandt
    Citation: BMC Medical Research Methodology 2024 24:87
  44. Prostate cancer is the most common cancer after non-melanoma skin cancer and the second leading cause of cancer deaths in US men. Its incidence and mortality rates vary substantially across geographical region...

    Authors: Ming Wang, Zheng Li, Jun Lu, Lijun Zhang, Yimei Li and Liangliang Zhang
    Citation: BMC Medical Research Methodology 2024 24:86
  45. Recruiting participants to clinical trials is an ongoing challenge, and relatively little is known about what recruitment strategies lead to better recruitment. Recruitment interventions can be considered comp...

    Authors: Natasha Hudek, Kelly Carroll, Seana Semchishen, Shelley Vanderhout, Justin Presseau, Jeremy Grimshaw, Dean A. Fergusson, Katie Gillies, Ian D. Graham, Monica Taljaard and Jamie C. Brehaut
    Citation: BMC Medical Research Methodology 2024 24:85
  46. The timing of treating cancer patients is an essential factor in the efficacy of treatment. So, patients who will not respond to current therapy should receive a different treatment as early as possible. Machi...

    Authors: Elham Majd, Li Xing and Xuekui Zhang
    Citation: BMC Medical Research Methodology 2024 24:83

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