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Research article
Estimating correlation coefficients among outcomes is one of the most important analytical tasks in epidemiological and clinical research. Availability of multivariate longitudinal data presents a unique oppor...
BMC Medical Research Methodology 2017 17:124
Published on: 17 August 2017
Research article
Self-interviews, where the respondent rather than the interviewer enters answers to questions, have been proposed as a way to reduce social desirability bias associated with interviewer-led interviews. Compute...
BMC Medical Research Methodology 2017 17:125
Published on: 17 August 2017
Research article
The objective consensus methodology has recently been applied in consensus finding in several studies on medical decision-making among clinical experts or guidelines. The main advantages of this method are an ...
BMC Medical Research Methodology 2017 17:123
Published on: 16 August 2017
Research article
This cohort study examined the impact of the lengths of lookback and confirmation periods as well as the definition of confirmatory events on the number of incident cancer cases identified and age-standardized...
BMC Medical Research Methodology 2017 17:122
Published on: 14 August 2017
Research article
Dentine hypersensitivity (DH) affects people’s quality of life (QoL). However changes in the internal meaning of QoL, known as Response shift (RS) may undermine longitudinal assessment of QoL. This study aimed...
BMC Medical Research Methodology 2017 17:120
Published on: 14 August 2017
Research article
Decisionmakers and guideline developers demand rapid syntheses of the evidence when time sensitive evidence-informed decisions are required. A potential trade-off of such rapid reviews is that their results ca...
BMC Medical Research Methodology 2017 17:121
Published on: 14 August 2017
Research Article
In clinical trials, the opportunity for an early stop during an interim analysis (either for efficacy or for futility) may relevantly save time and financial resources. This is especially important, if the pla...
BMC Medical Research Methodology 2017 17:119
Published on: 8 August 2017
Research article
Illness perceptions involve the personal beliefs that patients have about their illness and may influence health behaviours considerably. Since an instrument to measure these perceptions for Malay population i...
BMC Medical Research Methodology 2017 17:118
Published on: 3 August 2017
Research article
Information about design, implementation, monitoring and evaluation is central to understand the impact of programmes within the field of sexual, reproductive, maternal, newborn, child and adolescent health (S...
BMC Medical Research Methodology 2017 17:117
Published on: 3 August 2017
Research article
Each year over five million people develop chronic non-malignant pain and can experience healthcare as an adversarial struggle. The aims of this study were: (1) to bring together qualitative evidence syntheses...
BMC Medical Research Methodology 2017 17:116
Published on: 1 August 2017
Research Article
Random survival forest (RSF) models have been identified as alternative methods to the Cox proportional hazards model in analysing time-to-event data. These methods, however, have been criticised for the bias ...
BMC Medical Research Methodology 2017 17:115
Published on: 28 July 2017
Research article
Missing data is a common problem in epidemiological studies, and is particularly prominent in longitudinal data, which involve multiple waves of data collection. Traditional multiple imputation (MI) methods (f...
BMC Medical Research Methodology 2017 17:114
Published on: 25 July 2017
Research article
More patient-specific medical care is expected as more is learned about variations in patient responses to medical treatments. Analytical tools enable insights by linking treatment responses from different typ...
BMC Medical Research Methodology 2017 17:113
Published on: 20 July 2017
Research Article
The extended illness-death model is a useful tool to study the risks and consequences of hospital-acquired infections (HAIs). The statistical quantities of interest are the transition-specific hazard rates and...
BMC Medical Research Methodology 2017 17:111
Published on: 20 July 2017
Research Article
The analysis of perinatal outcomes often involves datasets with some multiple births. These are datasets mostly formed of independent observations and a limited number of clusters of size two (twins) and maybe...
BMC Medical Research Methodology 2017 17:110
Published on: 20 July 2017
Research Article
The Matchpoint trial aims to identify the optimal dose of ponatinib to give with conventional chemotherapy consisting of fludarabine, cytarabine and idarubicin to chronic myeloid leukaemia patients in blastic ...
BMC Medical Research Methodology 2017 17:112
Published on: 20 July 2017
Research Article
In a random effects meta-analysis model, true treatment effects for each study are routinely assumed to follow a normal distribution. However, normality is a restrictive assumption and the misspecification of ...
BMC Medical Research Methodology 2017 17:109
Published on: 19 July 2017
Research article
The application of adaptive design methodology within a clinical trial setting is becoming increasingly popular. However the application of these methods within trials is not being reported as adaptive designs...
BMC Medical Research Methodology 2017 17:108
Published on: 18 July 2017
Research Article
Joint models of longitudinal and time-to-event data are increasingly used to perform individual dynamic prediction of a risk of event. However the difficulty to perform inference in nonlinear models and to cal...
BMC Medical Research Methodology 2017 17:105
Published on: 17 July 2017
Debate
The standard definition for protocol adherence is the proportion of all scheduled doses that are delivered. In clinical research, this definition has several limitations when evaluating protocol adherence in t...
BMC Medical Research Methodology 2017 17:106
Published on: 17 July 2017
Debate
Distinguishing cohort studies from case series is difficult.
BMC Medical Research Methodology 2017 17:107
Published on: 17 July 2017
Technical advance
The sample size required to power a study to a nominal level in a paired comparative diagnostic accuracy study, i.e. studies in which the diagnostic accuracy of two testing procedures is compared relative to a...
BMC Medical Research Methodology 2017 17:102
Published on: 14 July 2017
Research article
Network meta-analysis overcomes the limitations of traditional pair-wise meta-analysis by incorporating all available evidence into a general statistical framework for simultaneous comparisons of several treat...
BMC Medical Research Methodology 2017 17:104
Published on: 14 July 2017
Research article
Prognostic models often show poor performance when applied to independent validation data sets. We illustrate how treatment use in a validation set can affect measures of model performance and present the uses...
BMC Medical Research Methodology 2017 17:103
Published on: 14 July 2017
Research article
African Americans have been historically under-represented in genetic studies. More research is needed on effective recruitment strategies for this population, especially on approaches that supplement traditio...
BMC Medical Research Methodology 2017 17:101
Published on: 14 July 2017
