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  1. Patient-Reported Outcomes (PROs) are standardized questionnaires used to measure subjective outcomes such as quality of life in healthcare. They are considered paramount to assess the results of therapeutic in...

    Authors: Antoine Vanier, Véronique Sébille, Myriam Blanchin and Jean-Benoit Hardouin

    Citation: BMC Medical Research Methodology 2021 21:128

    Content type: Research article

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  2. Kidney graft failure risk prediction models assist evidence-based medical decision-making in clinical practice. Our objective was to develop and validate statistical and machine learning predictive models to p...

    Authors: Sameera Senanayake, Sanjeewa Kularatna, Helen Healy, Nicholas Graves, Keshwar Baboolal, Matthew P. Sypek and Adrian Barnett

    Citation: BMC Medical Research Methodology 2021 21:127

    Content type: Research

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  3. Mortality is a key component of the natural history of COVID-19 infection. Surveillance data on COVID-19 deaths and case diagnoses are widely available in the public domain, but they are not used to model time...

    Authors: Ian C. Marschner

    Citation: BMC Medical Research Methodology 2021 21:126

    Content type: Research

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  4. Q-methodology is an approach to studying complex issues of human ‘subjectivity’. Although this approach was developed in the early twentieth century, the value of Q-methodology in healthcare was not recognised...

    Authors: Kate Churruca, Kristiana Ludlow, Wendy Wu, Kate Gibbons, Hoa Mi Nguyen, Louise A. Ellis and Jeffrey Braithwaite

    Citation: BMC Medical Research Methodology 2021 21:125

    Content type: Research

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  5. Mortality modelling in the critical care paradigm traditionally uses logistic regression, despite the availability of estimators commonly used in alternate disciplines. Little attention has been paid to covari...

    Authors: John L. Moran, John D. Santamaria and Graeme J. Duke

    Citation: BMC Medical Research Methodology 2021 21:124

    Content type: Research article

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  6. Due to clinical and methodological diversity, clinical studies included in meta-analyses often differ in ways that lead to differences in treatment effects across studies. Meta-regression analysis is generally...

    Authors: Michael Geissbühler, Cesar A. Hincapié, Soheila Aghlmandi, Marcel Zwahlen, Peter Jüni and Bruno R. da Costa

    Citation: BMC Medical Research Methodology 2021 21:123

    Content type: Research

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  7. Attrition is a major obstacle for lifestyle interventions sustained for the medium-to-long term and can have significant consequences on the internal validity of a trial. When the degree of attrition differs b...

    Authors: Bevens W, Shoushtari A, Jelinek P, Jelinek GA and Weiland TJ

    Citation: BMC Medical Research Methodology 2021 21:122

    Content type: Research

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  8. The International Classification of Functioning, Disability, and Health (ICF) Generic-30 (Rehabilitation) Set is a tool used to assess the functioning of a clinical population in rehabilitation. The ICF Generi...

    Authors: Yuki Senju, Masahiko Mukaino, Birgit Prodinger, Melissa Selb, Yuki Okouchi, Kouji Mizutani, Megumi Suzuki, Shin Yamada, Shin-Ichi Izumi, Shigeru Sonoda, Yohei Otaka, Eiichi Saitoh and Gerold Stucki

    Citation: BMC Medical Research Methodology 2021 21:121

    Content type: Research

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  9. Pandemic events often trigger a surge of clinical trial activity aimed at rapidly evaluating therapeutic or preventative interventions. Ensuring rapid public access to the complete and unbiased trial record is...

    Authors: Christopher W. Jones, Amanda C. Adams, Elizabeth Murphy, Rachel P. King, Benjamin Saracco, Karen R. Stesis, Susan Cavanaugh, Brian W. Roberts and Timothy F. Platts-Mills

    Citation: BMC Medical Research Methodology 2021 21:120

    Content type: Research article

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  10. Data-sharing policies in randomized clinical trials (RCTs) should have an evaluation component. The main objective of this case–control study was to assess the impact of published re-uses of RCT data in terms ...

    Authors: N. Anthony, C. Pellen, C. Ohmann, D. Moher and F. Naudet

    Citation: BMC Medical Research Methodology 2021 21:119

    Content type: Research

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  11. Loss to follow-up is a major challenge for very preterm (VPT) cohorts; attrition is associated with social disadvantage and parents with impaired children may participate less in research. We investigated the ...

    Authors: Aurélie Piedvache, Stef van Buuren, Henrique Barros, Ana Isabel Ribeiro, Elizabeth Draper and Jennifer Zeitlin

    Citation: BMC Medical Research Methodology 2021 21:118

    Content type: Research article

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  12. In the last decade Open Science principles have been successfully advocated for and are being slowly adopted in different research communities. In response to the COVID-19 pandemic many publishers and research...

    Authors: Lonni Besançon, Nathan Peiffer-Smadja, Corentin Segalas, Haiting Jiang, Paola Masuzzo, Cooper Smout, Eric Billy, Maxime Deforet and Clémence Leyrat

    Citation: BMC Medical Research Methodology 2021 21:117

    Content type: Commentary

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  13. We hypothesized that monitoring the volume of activity and overall performance indicators is not sufficient to understand the underlying differences between emergency departments. We aimed to understand the un...

    Authors: Marine Demarquet, Laurie Fraticelli, Julie Freyssenge, Clément Claustre, Mikaël Martinez, Jonathan Duchenne, Carlos El Khoury, Abdesslam Redjaline and Karim Tazarourte

    Citation: BMC Medical Research Methodology 2021 21:116

    Content type: Research

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  14. The monitoring and evaluation of public health programs based on traditional face-to-face interviews in hard-to-reach and unstable regions present many challenges. Mobile phone-based methods are considered to ...

    Authors: Xiaomeng Chen, Diwakar Mohan, Abdoulaye Maïga, Emily Frost, Djeneba Coulibaly, Luay Basil, Birahim Yaguemar Gueye, Mariam Traore Guindo, Assa Sidibé Keita, Haoua Dembelé Keita and Melissa A. Marx

    Citation: BMC Medical Research Methodology 2021 21:115

    Content type: Research article

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  15. Use of real world data (RWD) from non-randomised studies (e.g. single-arm studies) is increasingly being explored to overcome issues associated with data from randomised controlled trials (RCTs). We aimed to c...

    Authors: Janharpreet Singh, Keith R. Abrams and Sylwia Bujkiewicz

    Citation: BMC Medical Research Methodology 2021 21:114

    Content type: Research

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  16. In a star-shaped network, pairwise comparisons link treatments with a reference treatment (often placebo or standard care), but not with each other. Thus, comparisons between non-reference treatments rely on i...

    Authors: Jeong-Hwa Yoon, Sofia Dias and Seokyung Hahn

    Citation: BMC Medical Research Methodology 2021 21:113

    Content type: Technical advance

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  17. Neighbourhood is a complex structure but of high relevance for health. Its operationalisation remains however a challenge.The aim of this work is to present a new application of the use of semi-variograms as a...

    Authors: Odile Sauzet, Janne H. Breiding, Kim A. Zolitschka, Jürgen Breckenkamp and Oliver Razum

    Citation: BMC Medical Research Methodology 2021 21:112

    Content type: Research

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  18. Diagnostic accuracy studies aim to examine the diagnostic accuracy of a new experimental test, but do not address the actual merit of the resulting diagnostic information to a patient in clinical practice. In ...

    Authors: Amra Hot, Patrick M. Bossuyt, Oke Gerke, Simone Wahl, Werner Vach and Antonia Zapf

    Citation: BMC Medical Research Methodology 2021 21:110

    Content type: Research

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  19. Cardinality matching (CM), a novel matching technique, finds the largest matched sample meeting prespecified balance criteria thereby overcoming limitations of propensity score matching (PSM) associated with l...

    Authors: Stephen P. Fortin, Stephen S Johnston and Martijn J Schuemie

    Citation: BMC Medical Research Methodology 2021 21:109

    Content type: Research article

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  20. PR loss in ER+/HER2- breast cancer indicates worse prognosis and insensitivity to anti-estrogen therapy, while the mechanisms of PR loss in ER+/HER2- breast cancer remain unrevealed.

    Authors: Taobo Hu, Yan Chen, Yiqiang Liu, Danhua Zhang, Jiankang Pan and Mengping Long

    Citation: BMC Medical Research Methodology 2021 21:108

    Content type: Research

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  21. Sparse relative effectiveness evidence is a frequent problem in Health Technology Assessment (HTA). Where evidence directly pertaining to the decision problem is sparse, it may be feasible to expand the eviden...

    Authors: Georgios F. Nikolaidis, Beth Woods, Stephen Palmer and Marta O. Soares

    Citation: BMC Medical Research Methodology 2021 21:107

    Content type: Research article

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  22. A debilitating late effect for childhood cancer survivors (CCS) is cancer-related fatigue (CRF). Little is known about the prevalence and risk factors of fatigue in this population. Here we describe the method...

    Authors: Adriaan Penson, Sylvia van Deuren, Ewald Bronkhorst, Ellen Keizer, Tom Heskes, Marieke J. H. Coenen, Judith G. M. Rosmalen, Wim J. E. Tissing, Helena J. H. van der Pal, Andrica C. H. de Vries, Marry M. van den Heuvel-Eibrink, Sebastian Neggers, Birgitta A. B. Versluys, Marloes Louwerens, Margriet van der Heiden-van der Loo, Saskia M. F. Pluijm…

    Citation: BMC Medical Research Methodology 2021 21:106

    Content type: Research

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  23. Previous research has shown that chronic disease case definitions constructed using population-based administrative health data may have low accuracy for ascertaining cases of episodic diseases such as rheumat...

    Authors: Allison Feely, Lily SH Lim, Depeng Jiang and Lisa M. Lix

    Citation: BMC Medical Research Methodology 2021 21:105

    Content type: Research article

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  24. Tacrolimus is given post-kidney transplant to suppress the immune system, and the amount of drug in the body is measured frequently. Higher variability over time may be indicative of poor drug adherence, leadi...

    Authors: Kristen R. Campbell, Rui Martins, Scott Davis and Elizabeth Juarez-Colunga

    Citation: BMC Medical Research Methodology 2021 21:104

    Content type: Research

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  25. Practical methods for facilitating process improvement are needed to support high quality, safe care. How best to specify (identify and define) process improvements – the changes that need to be made in a heal...

    Authors: Jan W. van der Scheer, Matthew Woodward, Akbar Ansari, Tim Draycott, Cathy Winter, Graham Martin, Karolina Kuberska, Natalie Richards, Ruth Kern and Mary Dixon-Woods

    Citation: BMC Medical Research Methodology 2021 21:103

    Content type: Technical advance

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  26. Ninety-day hometime, the number of days a patient is living in the community in the first 90 after stroke, exhibits a non-normal bucket-shaped distribution, with lower and upper constraints making its analysis...

    Authors: Jessalyn K. Holodinsky, Amy Y. X. Yu, Moira K. Kapral and Peter C. Austin

    Citation: BMC Medical Research Methodology 2021 21:102

    Content type: Research article

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  27. Systematic reviews (SRs) and meta-analyses (MAs) are commonly conducted to evaluate and summarize medical literature. This is especially useful in assessing in vitro studies for consistency. Our study aims to ...

    Authors: Linh Tran, Dao Ngoc Hien Tam, Abdelrahman Elshafay, Thao Dang, Kenji Hirayama and Nguyen Tien Huy

    Citation: BMC Medical Research Methodology 2021 21:101

    Content type: Research article

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  28. Sample size calculation is a key point in the design of a randomized controlled trial. With time-to-event outcomes, it’s often based on the logrank test. We provide a sample size calculation method for a compo...

    Authors: Jordi Cortés Martínez, Ronald B. Geskus, KyungMann Kim and Guadalupe Gómez Melis

    Citation: BMC Medical Research Methodology 2021 21:99

    Content type: Research

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  29. Viral haemorrhagic fevers are characterized by irregular outbreaks with high mortality rate. Difficulties arise when implementing therapeutic trials in this context. The outbreak duration is hard to predict an...

    Authors: Pauline Manchon, Drifa Belhadi, France Mentré and Cédric Laouénan

    Citation: BMC Medical Research Methodology 2021 21:98

    Content type: Research article

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  30. In longitudinal critical care studies, researchers may be interested in summarizing an exposure over time and evaluating its association with a long-term outcome. For example, the number of days a patient has ...

    Authors: Rameela Raman, Wencong Chen, Michael O. Harhay, Jennifer L. Thompson, E. Wesley Ely, Pratik P. Pandharipande and Mayur B. Patel

    Citation: BMC Medical Research Methodology 2021 21:97

    Content type: Research article

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  31. Advances in machine learning (ML) provide great opportunities in the prediction of hospital readmission. This review synthesizes the literature on ML methods and their performance for predicting hospital readm...

    Authors: Yinan Huang, Ashna Talwar, Satabdi Chatterjee and Rajender R. Aparasu

    Citation: BMC Medical Research Methodology 2021 21:96

    Content type: Research article

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  32. Diagnosis performances of case-identifying algorithms developed in healthcare database are usually assessed by comparing identified cases with an external data source. When this is not feasible, intra-database...

    Authors: Nicolas H. Thurin, Pauline Bosco-Levy, Patrick Blin, Magali Rouyer, Jérémy Jové, Stéphanie Lamarque, Séverine Lignot, Régis Lassalle, Abdelilah Abouelfath, Emmanuelle Bignon, Pauline Diez, Marine Gross-Goupil, Michel Soulié, Mathieu Roumiguié, Sylvestre Le Moulec, Marc Debouverie…

    Citation: BMC Medical Research Methodology 2021 21:95

    Content type: Research article

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  33. Systematic reviews (SRs) are considered one of the most reliable types of studies in evidence-based medicine. SRs rely on a comprehensive and systematic data gathering, including the search of academic literat...

    Authors: Tobias Justesen, Josefine Freyberg and Anders N. Ø. Schultz

    Citation: BMC Medical Research Methodology 2021 21:94

    Content type: Research article

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  34. The availability of large epidemiological or clinical data storing biological samples allow to study the prognostic value of novel biomarkers, but efficient designs are needed to select a subsample on which to...

    Authors: Francesca Graziano, Maria Grazia Valsecchi and Paola Rebora

    Citation: BMC Medical Research Methodology 2021 21:93

    Content type: Research article

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  35. Clinical trials in home hospice settings are important to build the evidence base for practice, but balancing the burden and benefit of clinical trial conduct for clinicians, patients, and family caregivers is...

    Authors: Jennifer Tjia, Margaret Clayton, Germán Chiriboga, Brooke Staples, Geraldine Puerto, Lynley Rappaport and Susan DeSanto-Madeya

    Citation: BMC Medical Research Methodology 2021 21:92

    Content type: Research article

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  36. During the COVID-19 emergency, IRST IRCCS, an Italian cancer research institute and promoter of no profit clinical studies, adapted its activities and procedures as per European and national guidelines to main...

    Authors: Linda Valmorri, Bernadette Vertogen, Chiara Zingaretti, Anna Miserocchi, Roberta Volpi, Alberto Clemente, Isabella Bondi, Irene Valli, Britt Rudnas, Giovanni Martinelli and Oriana Nanni

    Citation: BMC Medical Research Methodology 2021 21:91

    Content type: Commentary

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  37. Healthcare-associated infections (HAIs) represent a major Public Health issue. Hospital-based prevalence studies are a common tool of HAI surveillance, but data quality problems and non-representativeness can ...

    Authors: A. D’Ambrosio, J. Garlasco, F. Quattrocolo, C. Vicentini and C. M. Zotti

    Citation: BMC Medical Research Methodology 2021 21:90

    Content type: Technical advance

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  38. Survival analyses methods (SAMs) are central to analysing time-to-event outcomes. Appropriate application and reporting of such methods are important to ensure correct interpretation of the data. In this study...

    Authors: Moses M. Ngari, Susanne Schmitz, Christopher Maronga, Lazarus K. Mramba and Michel Vaillant

    Citation: BMC Medical Research Methodology 2021 21:89

    Content type: Research article

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  39. Crowdsourcing engages the help of large numbers of people in tasks, activities or projects, usually via the internet. One application of crowdsourcing is the screening of citations for inclusion in a systemati...

    Authors: Anna H. Noel-Storr, Patrick Redmond, Guillaume Lamé, Elisa Liberati, Sarah Kelly, Lucy Miller, Gordon Dooley, Andy Paterson and Jenni Burt

    Citation: BMC Medical Research Methodology 2021 21:88

    Content type: Research article

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  40. Short-term associations between extreme heat events and adverse health outcomes are well-established in epidemiologic studies. However, the use of different exposure definitions across studies has limited our ...

    Authors: Shan Jiang, Joshua L. Warren, Noah Scovronick, Shannon E. Moss, Lyndsey A. Darrow, Matthew J. Strickland, Andrew J. Newman, Yong Chen, Stefanie T. Ebelt and Howard H. Chang

    Citation: BMC Medical Research Methodology 2021 21:87

    Content type: Research article

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  41. Health-related quality of life (HRQoL) tools are limited by the indicators included in the construct and variation in interpretation by different researchers. Neutral Theory describes the ideal construct that ...

    Authors: Ravi Jandhyala

    Citation: BMC Medical Research Methodology 2021 21:86

    Content type: Research article

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  42. Asset-based indices are widely-used proxy measures of wealth in low and middle-income countries (LMIC). The stability of these indices within households over time is not known.

    Authors: Jithin Sam Varghese, John A. Maluccio, Solveig A. Cunningham, Manuel Ramirez-Zea and Aryeh D. Stein

    Citation: BMC Medical Research Methodology 2021 21:85

    Content type: Research article

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  43. When quantifying the probability of survival in cancer patients using cancer registration data, it is common to estimate marginal relative survival, which under assumptions can be interpreted as marginal net s...

    Authors: Paul C. Lambert, Elisavet Syriopoulou and Mark R. Rutherford

    Citation: BMC Medical Research Methodology 2021 21:84

    Content type: Research article

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  44. Generalized linear mixed models (GLMMs), typically used for analyzing correlated data, can also be used for smoothing by considering the knot coefficients from a regression spline as random effects. The result...

    Authors: Muhammad Abu Shadeque Mullah, James A. Hanley and Andrea Benedetti

    Citation: BMC Medical Research Methodology 2021 21:83

    Content type: Research article

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  45. The COVID-19 pandemic has become a source of fear across the world. Measuring the level or significance of fear in different populations may help identify populations and areas in need of public health and edu...

    Authors: Ashley Elizabeth Muller, Jan Peter William Himmels and Stijn Van de Velde

    Citation: BMC Medical Research Methodology 2021 21:82

    Content type: Research article

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  46. Identifying how unwarranted variations in healthcare delivery arise is challenging. Experimental vignette studies can help, by isolating and manipulating potential drivers of differences in care. There is a la...

    Authors: Jessica Sheringham, Isla Kuhn and Jenni Burt

    Citation: BMC Medical Research Methodology 2021 21:81

    Content type: Research article

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  47. Research participation is beneficial to patients, clinicians and healthcare services. There is currently poor alignment between UK clinical research activity and local prevalence of disease. The National Insti...

    Authors: Tanvi Rai, Sharon Dixon and Sue Ziebland

    Citation: BMC Medical Research Methodology 2021 21:80

    Content type: Research article

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  48. An assumption in many analyses of longitudinal patient-reported outcome (PRO) data is that there is a single population following a single health trajectory. One approach that may help researchers move beyond ...

    Authors: Jae-Yung Kwon, Richard Sawatzky, Jennifer Baumbusch, Sandra Lauck and Pamela A. Ratner

    Citation: BMC Medical Research Methodology 2021 21:79

    Content type: Research article

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