Practical application of cure mixture model for long-term censored survivor data from a withdrawal clinical trial of patients with major depressive disorder

Table 2 Result of standard logistic and Cox regressions to a sertraline randomized withdrawal study in patients with MDD

			95% CI
Standard logistic regression	Estimates	SE	Lower	Upper	p-value
Intercept	1.686	1.687	-1.621	4.992	0.3178
Treatment	0.968	0.429	0.152	1.848	0.0239
Baseline HAM-D score at OP	0.007	0.062	-0.111	0.134	0.9096
Baleline HAM-D score at DP	-0.100	0.068	-0.240	0.029	0.1443
Gender	-1.842	0.575	-3.123	-0.817	0.0014
Age	0.026	0.020	-0.013,	0.068	0.2020
The number of episodes	0.174	0.139	-0.016	0.531	0.2111
Duration from the 1st episode	-0.002	0.003	-0.008	0.005	0.5575
Duration of this episode	-0.002	0.022	-0.041	0.046	0.9296
Interval from the previous episode	0.004	0.007	-0.008	0.019	0.5553
Complication	0.572	0.413	-0.241	1.388	0.1654
Maximum log-likelihood	-81.603
AIC	185.206
			95% CI
*Standard Cox regression*	Estimates	SE	Lower	Upper	p-value
Treatment	-0.845	0.388	-1.604	-0.086	0.0293
Baseline HAM-D score at OP	0.005	0.053	-0.099	0.109	0.9222
Baseline HAM-D score at DP	0.063	0.059	-0.052	0.180	0.2847
Gender	1.639	0.543	0.575	2.702	0.0025
Age	-0.023	0.018	-0.058	0.012	0.1977
The number of episodes	-0.152	0.130	-0.406	0.102	0.2399
Duration from the 1st episode	0.002	0.003	-0.004	0.007	0.5729
Duration of this episode	0.005	0.019	-0.033	0.042	0.8038
Interval from the previous episode	-0.003	0.006	-0.014	0.009	0.6274
Complication	-0.518	0.358	-1.221	0.184	0.1482
Maximum log-likelihood*	-180.917
AIC	381.834

ISSN: 1471-2288