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Table 3 Coverage probability for the 95% confidence interval of the simple product-based estimator (ESRS) and revised product-based estimator (ESRR) using a log-based variance

From: Evaluation of exposure-specific risks from two independent samples: A simulation study

Low exposure probability (.05)/Low disease probability in unexposed (.02)

 

N1 = 1,000, N2 = 1,000

N1 = 5,000, N2 = 5,000

RR/ESR

ESRS

ESRR

ESRS

ESRR

1.0/.02

96.8

97.3

97.5

97.5

2.0/.04

96.4

98.1

95.9

97.2

3.0/.06

95.7

98.3

92.7

96.6

4.0/.08

94.1

98.2

90.3

98.0

5.0/.10

93.9

98.4

87.1

97.7

Low exposure probability (.05)/Moderate disease probability in unexposed (.09)

 

N1 = 1,000, N2 = 1,000

N1 = 5,000, N2 = 5,000

RR/ESR

ESRS

ESRR

ESRS

ESRR

1.0/.09

96.8

97.2

95.9

96.2

2.0/.18

95.8

96.8

93.4

96.3

3.0/.27

94.3

97.0

87.8

96.4

4.0/.36

89.3

96.1

70.8

97.0

5.0/.45

83.2

96.6

45.0

96.6

High exposure probability (.20)/Low disease probability in unexposed (.02)

 

N1 = 1,000, N2 = 1,000

N1 = 5,000, N2 = 5,000

RR/ESR

ESRS

ESRR

ESRS

ESRR

1.0/.02

97.6

98.5

94.5

96.6

2.0/.04

94.2

98.9

85.6

98.0

3.0/.06

89.5

99.0

55.1

98.6

4.0/.08

76.8

99.2

22.3

99.4

5.0/.10

65.4

99.6

4.2

99.4

High exposure probability (.20)/Moderate disease probability in unexposed (.09)

 

N1 = 1,000, N2 = 1,000

N1 = 5,000, N2 = 5,000

RR/ESR

ESRS

ESRR

ESRS

ESRR

1.0/.09

94.7

96.8

94.7

96.5

2.0/.18

85.4

98.5

51.1

98.0

3.0/.27

55.9

98.5

1.8

98.6

4.0/.36

17.6

99.4

0

99.4

5.0/.45

2.9

99.5

0

99.4

  1. N1 is the sample the overall risk is derived from
  2. N2 is the sample the relative risk is derived from
  3. Relative Risk/Exposure-Specific Risk (RR/ESR) values are the hypothesized values
  4. Italics denote coverage probabilities that did not attain 95%