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Table 8 Properties of point and 95% interval estimates calculated from Models A - E based on 1000 simulated datasets in scenario 9 - unbalanced, 46 centres, same centre composition as the COMPETE II trial.

From: Comparing methods to estimate treatment effects on a continuous outcome in multicentre randomized controlled trials: A simulation study

 

SCENARIO 9

Model

Mean effect

(SD)

Ave.

SE

MSE

Cover.

of CI

Power

ICC = 0.125

A

1.254

(0.236)

0.249

0.056

0.965

0.999

B

1.253

(0.240)

0.236

0.058

0.952

1

C

1.253

(0.237)

0.235

0.056

0.949

0.999

D

1.253

(0.237)

0.230

0.056

0.944

0.999

E-1

1.256

(0.405)

0.207

0.165

0.787

0.991

E-2

1.257

(0.270)

0.261

0.073

0.935

0.995

  1. SD: empirical standard deviation; Ave. SE: average estimated SE; MSE: mean squared error; Cover. of CI: coverage proportion of 95% confidence interval; ICC: intraclass (intracentre) correlation
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BMC Medical Research Methodology

ISSN: 1471-2288

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