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Table 2 Thresholds by DESR to compare with the rules of Gehan (r alt = 0.2, r nul = 0.05, epd alt = 0.4, epd nul = 0.6, power = 0.8, alpha = 0.05)

From: A comparison of a new multinomial stopping rule with stopping rules of fleming and gehan in single arm phase II cancer clinical trials

Study Size Stage 1 Drug Rejection Stage 2 Drug Acceptance Power Alpha Error ENnul/PESnul ENalt/PESalt
n 1 n 2 n 1r n 1p n 1r+n 2r n 1p+n 2p     
14 1 ≤1/14 ≥8/14 ≥2/17 ≤7/17 0.835 0.089 14.1/0.89 14.9/0.14
14 3 ≤1/14 ≥8/14 ≥2/17 ≤9/17 0.855 0.101 14.3/0.89 17.0/0.008
14 4 ≤1/14 ≥8/14 ≥3/18 ≤9/18 0.797 0.051 14.4/0.89 17.4/0.14
14 5 ≤1/14 ≥8/14 ≥3/19 ≤9/19 0.787 0.041 14.6/0.89 18.3/0.14
14 6 ≤1/14 ≥8/14 ≥3/20 ≤9/20 0.776 0.034 14.7/0.89 19.2/0.14
14 9 ≤1/14 ≥8/14 ≥3/23 ≤11/23 0.814 0.04 15.0/0.89 21.7/0.14
14 10 ≤1/14 ≥8/14 ≥3/24 ≤12/24 0.829 0.046 15.1/0.89 23.9/0.008
14 11 ≤1/14 ≥8/14 ≥4/25 ≤12/25 0.779 0.035 15.2/0.89 24.9/0.008
14 13 ≤1/14 ≥8/14 ≥4/27 ≤14/27 0.817 0.032 15.4/0.89 25.2/0.14
14 15 ≤1/14 ≥8/14 ≥4/29 ≤14/29 0.807 0.032 15.7/0.89 26.9/0.14
14 16 ≤1/14 ≥8/14 ≥4/30 ≤14/30 0.8 0.027 15.8/0.89 27.8/0.14
14 18 ≤1/14 ≥8/14 ≥4/32 ≤16/32 0.829 0.026 16.0/0.89 29.5/0.14
14 20 ≤1/14 ≥8/14 ≥5/34 ≤17/34 0.809 0.0174 16.2/0.89 31.2/0.14
14 21 ≤1/14 ≥8/14 ≥5/35 ≤17/35 0.804 0.021 16.3/0.89 32.0/0.14
14 22 ≤1/14 ≥8/14 ≥5/36 ≤19/36 0.83 0.024 16.4/0.89 32.9/0.14
14 23 ≤1/14 ≥8/14 ≥5/37 ≤19/37 0.828 0.02 16.5/0.89 33.8/0.14
  1. ENnul = expected number of patients accrued if a drug meets the criteria of the null hypothesis
  2. ENalt = expected number of patients accrued if a drug meets the criteria of the alternate hypothesis
  3. PESnul = probability of stopping the trial after stage I if a drug meets the criteria of the null hypothesis
  4. PESalt = probability of stopping the trial after stage I if a drug meets the criteria of the alternate hypothesis