Table 2 Dose and incremental ratios in 81 modified-Fibonacci-sequence designed studies
From: What does a modified-Fibonacci dose-escalation actually correspond to?
Planned dose in | Actual doses | |||||
|---|---|---|---|---|---|---|
Dose-level (nof studies reaching the dose-level) | Genuine Fibonacci sequence | Modified Fibonacci sequence | Median of actual dose | Min. of actual dose | Max. of actual dose | Mean (± SD) of actual dose |
1(81) | 1 | 1.0 | 1 | - | - | - |
2(81) | 2 | 2.0 | 2.00 | 0.80 | 10 | 1.82 (0.65) |
3 (77) | 3 | 3.3 | 3.00 | 0.80 | 3.33 | 4.08 (1.65) |
4 (67) | 5 | 5.1 | 4.00 | 0.97 | 10.00 | 9.23 (3.12) |
5 (58) | 8 | 6.60 | 5.32 | 1.20 | 33.33 | 17.61 (4.71) |
6 (43) | 13 | 8.80 | 7.80 | 0.90 | 56.25 | 34.49 (6.89) |
7 (32) | 21 | 11.8 | 11.93 | 1.86 | 80.00 | 67.96 (9.77) |
8 (19) | 34 | 15.6 | 15.78 | 6.67 | 128.00 | 35.64 (5.43) |
9 (13) | 55 | 20.8 | 19.50 | 13.33 | 256.00 | 78.11 (8.69) |
10 (7) | 89 | 27.8 | 23.00 | 18.00 | 512.00 | 133.38 (12.69) |
11 (5) | 144 | 36.8 | 28.89 | 23.50 | 1024.00 | 227.16 (17.85) |
12 (3) | 233 | 49.0 | 38.44 | 35.83 | 2048.00 | 707.43 (29.89) |
13 (0) | 377 | 65.2 | - | - | - | - |