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Table 2 Dose and incremental ratios in 81 modified-Fibonacci-sequence designed studies

From: What does a modified-Fibonacci dose-escalation actually correspond to?

  Planned dose in Actual doses
Dose-level (nof studies reaching the dose-level) Genuine Fibonacci sequence Modified Fibonacci sequence Median of actual dose Min. of actual dose Max. of actual dose Mean (± SD) of actual dose
1(81) 1 1.0 1 - - -
2(81) 2 2.0 2.00 0.80 10 1.82 (0.65)
3 (77) 3 3.3 3.00 0.80 3.33 4.08 (1.65)
4 (67) 5 5.1 4.00 0.97 10.00 9.23 (3.12)
5 (58) 8 6.60 5.32 1.20 33.33 17.61 (4.71)
6 (43) 13 8.80 7.80 0.90 56.25 34.49 (6.89)
7 (32) 21 11.8 11.93 1.86 80.00 67.96 (9.77)
8 (19) 34 15.6 15.78 6.67 128.00 35.64 (5.43)
9 (13) 55 20.8 19.50 13.33 256.00 78.11 (8.69)
10 (7) 89 27.8 23.00 18.00 512.00 133.38 (12.69)
11 (5) 144 36.8 28.89 23.50 1024.00 227.16 (17.85)
12 (3) 233 49.0 38.44 35.83 2048.00 707.43 (29.89)
13 (0) 377 65.2 - - - -
  1. n: number of studied reaching the specified dose-level; SD: standard deviation.