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Table 4 Results of Correction Procedure for Hypothetical Data on SNP B-type Error after Increasing Size of Misclassification Sample

From: Statistical adjustment of genotyping error in a case–control study of childhood leukaemia

 

‘Recessive’ artificial SNP 1

‘Log additive’ artificial SNP 2

 

             Aa

             aa

             Aa

       aa

Size increase of misclassification sample

OR

 95% CIa

OR

 95% CIa

OR

 95% CIa

OR

 95% CIa

0.5 x size

1.01

0.66, 1.55

1.98

1.15, 3.38

1.30

0.85, 1.99

1.63

0.93, 2.84

1 x

1.01

0.70, 1.45

1.99

1.21, 3.26

1.30

0.91, 1.85

1.63

0.97, 2.75

5x size

1.00

0.71, 1.41

2.00

1.26, 3.19

1.29

0.92, 1.80

1.65

1.01, 2.69

  1. OR = Odds ratio; CI = confidence interval; Aa = Heterozygous genotype; aa = Homozygous mutant genotype.
  2. aConfidence intervals based on Wald method for uncorrected estimates and percentile-based for corrected estimates.