Table 3 Change in symptom domains per standard validated measures by RAD reasons for study drug continuation
Groups based on RAD-Q | Groups based on RAD-I | |||||||
|---|---|---|---|---|---|---|---|---|
RAD domain | Item | Comparator | N | Mean change (SE) | p-value | N | Mean change (SE) | p-value |
Positive Symptoms | Benefits | PANSS Positive | ||||||
Yes | 215 | −10.4 (0.4) | 206 | −10.7 (0.4) | ||||
No | 20 | −5.2 (1.5) | .001 | 30 | −5.6 (0.8) | .001 | ||
Negative Symptoms | Benefits | PANSS Negative | ||||||
Yes | 111 | −7.8 (0.5) | 110 | −7.6 (0.5) | ||||
No | 90 | −2.9 (0.5) | .001 | 112 | −3.5 (0.5) | .001 | ||
Mood Items | Benefits | PANSS Anxiety/Depression | ||||||
Yes | 113 | −5.7 (0.4) | 139 | −5.5 (0.3) | ||||
No | 97 | −3.4 (0.4) | .001 | 83 | −3.3 (0.4) | .001 | ||
Cognition Items | Benefits | PANSS Cognition | ||||||
Yes | 108 | −7.7 (0.5) | 131 | −7.1 (0.5) | ||||
No | 102 | −4.0 (0.4) | .001 | 91 | −4.1 (0.4) | .001 | ||
Functioning Items | Benefits | QLS Total | ||||||
Yes | 137 | 25.1 (2.0) | 141 | 23.4 (2.0) | ||||
No | 81 | 7.3 (2.0) | .001 | 88 | 8.5 (2.0) | .001 | ||
Social Support Items | Family/Friends Support | QLS Interpersonal Relations | ||||||
Yes | 43 | 7.0 (1.4) | 45 | 7.6 (1.3) | ||||
No | 181 | 8.1 (0.8) | .512 | 186 | 7.7 (0.8) | .975 | ||