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Table 5 Estimated parameters of the conditional LCAs in the OHTS and EGPS data

From: The effect of changes in intraocular pressure on the risk of primary open-angle glaucoma in patients with ocular hypertension: an application of latent class analysis

OHTS

Variables

Parameters for IOP change and the effects of covariates on class membership

Effects on POAG

 

Class 1

Class2 (Ref.)

Class 3

Class 4

Class 5

Class 6

 

Class Size IOP Change

14.2%

27.1%

21.1%

9.1%

17.6%

10.9%

 

 I

17.58(0.20)#

19.83(0.21)#

22.30(0.21)#

22.82(0.79)#

24.74(0.22)#

27.70(0.28)#

-

 L

−0.57(0.08)#

−0.53(0.06)#

−0.47(0.09)#

−0.95(0.30)#

−0.20(0.09)*

0.16(0.17)

-

 Q

0.06(0.01)#

0.05(0.01)#

0.05(0.01)#

0.07(0.04)

0.02(0.02)

−0.05(0.03)

-

 V

4.36(0.27)#

4.30(0.32)#

4.80(0.25)#

16.07(1.46)#

4.66(0.31)#

12.15(1.15)#

-

Covariates

       

 Intercept

−2.64(0.63)#

 

2.08(0.47)#

−0.06(0.47)

2.35(0.54)#

1.04(0.61)

-

 TRT

1.60(0.66)*

-

−3.25(0.35)#

−2.19(0.63)#

−5.98(0.56)#

−6.46(0.70)#

0.16(0.29)

 MALE

0.25(0.23)

-

−0.99(0.24)#

0.24(0.27)

−0.68(0.28)*

−0.22(0.30)

0.23(0.19)

 RACEB

−0.10(0.27)

-

−0.37(0.30)

0.75(0.31)*

−0.91(0.34)*

0.05(0.37)

−0.05(0.24)

 AGE

0.06(0.12)

-

−0.01(0.12)

0.08(0.16)

−0.05(0.14)

0.13(0.15)

0.18(0.09) *

 IOP0

−0.79(0.18)#

-

0.21(0.22)

1.03(0.36)*

0.89(0.18)#

1.73(0.22)#

−0.10(0.11)

 CCT

−0.35(0.12)*

-

0.18(0.11)

−0.08(0.17)

0.14(0.13)

0.09(0.16)

−0.64(0.13)#

 PSD

0.13(0.11)

-

0.04(0.11)

0.08(0.13)

0.17(0.13)

0.12(0.15)

0.23(0.10)*

 VCD

0.06(0.11)

-

−0.08(0.12)

−0.15(0.17)

−0.10(0.13)

−0.09(0.15)

0.60(0.10)#

 BB

−0.60(0.48)

-

−0.37(0.61)

- **

−0.30(0.62)

−1.21(0.77)

0.19(0.57)

 CHB

−0.19(0.37)

-

−0.32(0.42)

0.47(0.45)

−0.42(0.44)

−0.50(0.49)

0.09(0.31)

 DM

−0.23(0.35)

-

0.22(0.32)

−0.71(0.45)

0.23(0.36)

0.64(0.40)

−1.67(0.53)*

 HEART

0.70(0.44)

-

0.10(0.49)

0.43(0.56)

−0.09(0.56)

−0.48(0.73)

0.71(0.29)*

 HBP

0.47(0.24)*

-

0.40(0.27)

0.06(0.34)

0.41(0.30)

0.66(0.33)*

0.08(0.22)

EGPS

Variables

Parameters for IOP change and the effects of covariates on class membership

Effects on POAG

 
 

Class1 (Ref.)

Class 2

Class 3

Class 4

Class 5

  

Class Size IOP Change

26.3%

20.1%

29.3%

12.9%

11.4%

  

 I

18.66(0.25) #

18.24(0.18)#

21.24(0.20)#

21.85(0.47)#

24.33(0.34)#

-

 

 L

−0.34(0.14)*

−1.29(0.18)#

−0.25(0.11)*

−1.76(0.28)#

0.06(0.26)

-

 

 Q

0.05(0.03)

0.11(0.04)*

0.02(0.03)

0.02(0.07)

−0.08(0.07)

-

 

 V

3.79(0.23)#

3.75(0.25)#

4.59(0.24)#

7.12(0.85)#

12.17(1.32)#

-

 

Covariates

       

 Intercept

-

−0.84(0.33)*

0.30(0.28)

−0.85(0.58)

−0.71(0.34)*

-

 

 TRT

-

0.36(0.27)

−0.65(0.23)*

−0.58(0.37)

−1.79(0.37)#

−0.01(0.21)

 

 MALE

-

−0.35(0.29)

0.14(0.23)

0.18(0.40)

0.38(0.33)

−0.24(0.22)

 

 Black

-

-

-

-

-

-

 

 AGE

-

−0.09(0.16)

0.01(0.13)

0.40(0.23)

0.45(0.20)*

0.16(0.10)

 

 IOP0

-

−0.61(0.24)*

0.82(0.17)#

1.24(0.24)#

1.79(0.23)#

0.11(0.13)

 

 CCT

-

−0.33(0.13)*

−0.14(0.12)

−0.43(0.15)*

0.09(0.15)

−0.36(0.12)*

 

 PSD

-

0.27(0.16)

−0.23(0.14)

−0.18(0.24)

−0.41(0.23)

0.18(0.09)*

 

 VCD

-

−0.13(0.17)

−0.03(0.13)

0.72(0.26)*

0.17(0.16)

0.46(0.12)#

 

 BB

-

−0.17(0.50)

−0.82(0.52)

- **

−0.58(0.69)

−0.07(0.41)

 

 CHB

-

−0.10(0.56)

−0.97(0.52)

0.89(1.03)

−1.22(0.79)

−0.28(0.47)

 

 DM

-

−0.46(0.52)

0.12(0.45)

−1.32(1.27)

0.82(0.81)

−0.18(0.54)

 

 HEART

-

0.78(0.41)

0.11(0.44)

−0.83(0.77)

−0.79(0.61)

0.74(0.32)*

 

 HBP

-

0.02(0.36)

0.53(0.30)

−1.27(0.90)

0.11(0.54)

0.24(0.26)

 
  1. *: p < 0.05; #: p < 0.001; **: Not estimable due to zero count of beta blocker use in the given class.
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BMC Medical Research Methodology

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