Trial | Year | Trial Size | Mean Trial Duration (yrs) | Prevention | Drug (first agent/s) | Add on Drug (s)# | Drug Class* | Mean SBP* at base- line | Mean DBP* at base- line | Mean Age | Male % | Diabetes % | Smoker % |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ANBP1 [26] | 1980 | 3427 | 4 | Primary | chlorothiazide | N | 0,1,2 | 157.4 | 100.5 | 50.4 | 63.0 | 0.0 | 25.0 |
IPPPSH [27] | 1985 | 6357 | 4 | Mixed | Oxprenolol | Y | 1,2 | 173.0 | 107.5 | 52.2 | 50.2 | Â | 29.1 |
MRC-mild [28] | 1985 | 17354 | 5 | Mixed | bendrofluazide or propranolol | N | 1,2 | 161.5 | 98.5 | 50.0 | 50.0 | Â | 31.0 |
HEP [29] | 1986 | 884 | 8 | Primary | Atenolol | N | 0,1,2 | 196.4 | 98.9 | 68.8 | 30.9 | 0.0 | 24.3 |
SHEP [30] | 1991 | 4736 | 4.5 | Primary | Chlorthalidone | N | 1,2 | 170.3 | 76.6 | 71.6 | 43.2 | 10.1 | 12.7 |
STOP [31] | 1991 | 1627 | 2.1 | Primary | atenolol or hydrochlorothiazide + amiloride or metoprolol or pindolol | N | 1,2 | 195.0 | 102.0 | 75.7 | 37.0 | Â | 8.0 |
MRC-elderly [32] | 1992 | 4396 | 5.8 | Primary | atenolol or amiloride/ hydrochlorothiazide | N | 1,2 | 184.7 | 90.7 | 70.3 | 41.8 | 0.0 | 17.5 |
PATS [33] | 1995 | 5665 | 2 | Secondary | Indapamide | N | 1 | 153.8 | 92.8 | 60.0 | 72.0 | Â | Â |
Syst-Eur [34] | 1997 | 4695 | 2 | Primary | Nitrendipine | N | 1,3,4 | 173.9 | 85.5 | 70.3 | 33.2 | Â | 7.3 |
PREVENT [35] | 2000 | 825 | 3 | Secondary | Amlodipine | Y | 2,3,4 | 129.4 | 78.9 | 56.9 | 80.1 | Â | 24.7 |
PROGRESS [36] | 2001 | 6105 | 4 | Secondary | Perindopril | N | 1,3 | 147.0 | 86.0 | 64.0 | 70.0 | 12.5 | 20.0 |
EUROPA [37] | 2003 | 12218 | 4.2 | Secondary | Perindopril | Y | 1,2,3,4 | 137.0 | 82.0 | 60.0 | 85.4 | 12.3 | Â |
SCOPE [38] | 2003 | 4937 | 3.7 | Primary | Candesartan | Y | 1,2,3,4,5 | 166.3 | 90.4 | 76.4 | 35.5 | 12.0 | 8.7 |
HYVET-pilot [39] | 2003 | 857 | 1.1 | Primary | bendroflumethiazide or lisinopril | N | 1,3,4 | 181.5 | 99.6 | 83.8 | 36.6 | Â | 4.2 |
PEACE [40] | 2004 | 8290 | 4.8 | Secondary | Trandolapril | Y | 1,2,3,4 | 133.5 | 78.0 | 64.0 | 82.0 | 17.0 | 14.5 |
ACTION [41] | 2004 | 7665 | 4.9 | Secondary | Nifedipine | Y | 1,2,3,4 | 137.5 | 79.9 | 63.4 | 79.4 | 14.5 | 17.7 |
TRANSCEND [42] | 2008 | 5926 | 4.7 | Secondary | Telmisartan | Y | 1,2,4,5 | 141.0 | 81.9 | 66.9 | 57.0 | 35.7 | 9.8 |
HYVET-main [43] | 2008 | 3845 | 2.1 | Primary | Indapamide | N | 1,4 | 173.0 | 90.8 | 83.6 | 39.5 | 6.8 | 6.5 |