Table 5 Efficacy of atypical antipsychotics in elderly patients with dementia: Number needed to treat

Clinical End Point

>50% Improvement in Behave-AD ¹ total score

Katz [62]

Double-blind placebo controlled RCT (n=625)

12 weeks

(45%)

(33%)

12%

8

Schneider [6]

Meta Analysis of 3 studies (n=1001)

12 weeks

266/574 (46%)

139/427 (33%)

14%

7.4

>30% Improvement in Behave-AD ¹ total score

DeDeyn [8]

Double-blind placebo controlled RCT (n=344)

12 weeks

(72%)

(61%)

11%

9

CGI-C ² (much/very much improved)

Brodaty [61]

Double-blind placebo controlled RCT (n=93)

12 weeks

27/46 (59%)

12/47 (26%)

33%

3.3

Schneider [6]

Meta Analysis of 2 studies (n=717)

8-12 weeks

227/351 (65%)

175/366 (48%)

17%

6

Katz [5]

Meta Analysis of 4 studies (n=889)

End point

(28%)

(17%)

11%

9

Sultzer [63]

Double-blind placebo controlled RCT (n=421)

12 weeks

(61%)

(40%)

21%

5