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Table 2 Multivariate Cox model for FTR and results of the MRS in the STR group : (i) the first three columns provides the results of the multivariate Cox model analysis of graft failure risk factors for FTR (N = 2206); (ii) the next three columns provide the results of the relative survival model based on 540 STR (26 recipients presenting missing data for the waiting time before re-transplantation were excluded)

From: Comparison of the risk factors effects between two populations: two alternative approaches illustrated by the analysis of first and second kidney transplant recipients

 

Cox model in

MRS in

 

the FTR group

the STR group

 

HR

95% CI

p-value

HR

95% CI

p-value

Variables entering in the model for FTR only

      

Causal nephropathy (recurrent / non recurrent)

1.24

0.96-1.59

0.0987

-

-

-

History of diabetes (positive / negative)

1.34

0.96-1.85

0.0819

-

-

-

History of hypertension (positive / negative)

0.77

0.57-1.05

0.0986

-

-

-

History of cardiac disease (positive / negative)

1.41

1.11-1.79

0.0051

-

-

-

History of vascular disease (positive / negative)

1.10

0.81-1.51

0.5351

-

-

-

History of dyslipemia (positive / negative)

1.12

0.87-1.45

0.3828

-

-

-

History of hepatitis B/C (positive / negative)

0.82

0.45-1.47

0.4969

-

-

-

History of malignancy (positive / negative)

1.25

0.84-1.86

0.2698

-

-

-

Body mass index (≥ 30 kg.m-2 / < 30 kg.m-2)

1.58

1.12-2.14

0.0084

-

-

-

Anti-class I PRA (positive / negative)

1.45

1.07-1.97

0.0182

-

-

-

Anti-class II PRA (positive / negative)

1.09

0.78-1.52

0.6299

-

-

-

Donor status (deceased/living)

2.50

1.41-4.43

0.0016

-

-

-

Donor EBV serology (positive / negative)

1.65

0.98-2.78

0.0606

-

-

-

Number of HLA-A-B-DR mismatches (> 4 / ≤ 4)

1.30

0.97-1.76

0.0824

-

-

-

Induction therapy (depleting / non depleting)

0.79

0.60-1.05

0.1091

-

-

-

Cold ischemia time (≥ 24 h / < 24 h)

1.29

1.01-1.66

0.0441

-

-

-

Variables entering in both models

      

Transplantation period (< 2005 / ≥ 2005)

1.33

0.97-1.82

0.0693

0.97

0.55-1.74

0.9360

Recipient gender (male / female)

1.17

0.91-1.51

0.2186

0.61

0.38-1.05

0.0720

Recipient age (≥ 55 years / < 55 years)

1.39

1.05-1.83

0.0204

1.65

1.01-2.72

0.0480

Donor age (≥55 years / <55 years)

1.34

1.03-1.74

0.0313

0.59

0.33-0.99

0.0440

Variables entering in the model for STR only

      

Donor gender (male / female)

-

-

-

1.53

1.03-2.48

0.0320

Waiting time before regraft ≥ 3 years

-

-

-

1.92

1.22-3.00

<0.0001

  1. PRA, panel reactive antibody; EBV, Epstein-Barr virus; HLA, human leukocyte antigen.