Table 1 Sample size calculations for hypothetical trials with proportional or non-proportional hazards of the treatment effect

Recruit

Follow-up

PH designs

Non-PH designs

RMST

Logrank

RMST

Logrank

(K ₁, yr)

(K ₂, yr)

${\mathbf{t}}_{\mathbf{\text{des}}}^{\mathbf{\ast }}$

n

Events

n

Events

${\mathbf{t}}_{\mathbf{\text{des}}}^{\mathbf{\ast }}$

n

Events

n

Events