Skip to main content

Table 1 Sample size calculations for hypothetical trials with proportional or non-proportional hazards of the treatment effect

From: Restricted mean survival time: an alternative to the hazard ratio for the design and analysis of randomized trials with a time-to-event outcome

Recruit Follow-up PH designs   Non-PH designs  
   RMST Logrank RMST Logrank
(K 1, yr) (K 2, yr) t des n Events n Events t des n Events n Events
1 7 8 424 368 415 359 4.4 324 286 412 364
2 6 8 426 363 422 359 4.5 324 281 406 351
3 5 8 432 360 431 359 4.4 325 275 399 337
4 4 8 440 356 444 359 4.5 325 266 393 322
5 3 7.5 463 360 462 359 4.3 328 258 389 305
6 2 7.0 488 359 490 359 4.1 332 245 391 288
7 1 6.7 532 359 533 360 3.8 351 237 406 273
  1. See the text for further details.