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Table 6 HR, RMST and derived statistics on survival for four randomized controlled trials in various cancer sites conducted by the Medical Research Council

From: Restricted mean survival time: an alternative to the hazard ratio for the design and analysis of randomized trials with a time-to-event outcome

Statistic ASTEC BA06 ICON4 OE02
t max (yr) 6.8 6.7 6.4 10.8
t final (yr) 6.1 6.7 6.3 10.8
S (t ) 0.72 0.39 0.082 0.11
N (events a) 1394 (188) 962 (483) 749 (417) 802 (655)
Design HR 0.75 0.75 0.75 0.75
Achieved HR 1.16 0.85 0.82 0.85
(Cox model)     
P-value for HR 0.3 0.07 0.04 0.03
(logrank test)     
P-value for non-PH 0.06 0.7 0.6 0.1
(G-T test b)     
RMST in control 5.39 3.69 2.46 2.68
arm ( μ ̂ 0 )     
RMST in research 5.28 4.02 2.79 3.13
arm ( μ ̂ 1 )     
Diff. Δ ̂ = -0.11 (0.10) 0.33 (0.18) 0.33 (0.17) 0.46 (0.26)
μ ̂ 1 - μ ̂ 0 (SE)     
P-value for 0.3 0.07 0.05 0.08
Δ ̂ (RMST test)     
P-value for 0.07 0.4 0.7 0.04
non-PH c     
  1. See text for details.
  2. aEvents occurring in the interval (0,t *).
  3. bGrambsch-Therneau test
  4. cFrom a flexible parametric hazards model with a time-dependent treatment effect.