Statistic
|
ASTEC
|
BA06
|
ICON4
|
OE02
|
---|
t max (yr)
|
6.8
|
6.7
|
6.4
|
10.8
|
(yr)
|
6.1
|
6.7
|
6.3
|
10.8
|
S (t
∗)
|
0.72
|
0.39
|
0.082
|
0.11
|
N (events a)
|
1394 (188)
|
962 (483)
|
749 (417)
|
802 (655)
|
Design HR
|
0.75
|
0.75
|
0.75
|
0.75
|
Achieved HR
|
1.16
|
0.85
|
0.82
|
0.85
|
(Cox model)
| | | | |
P-value for HR
|
0.3
|
0.07
|
0.04
|
0.03
|
(logrank test)
| | | | |
P-value for non-PH
|
0.06
|
0.7
|
0.6
|
0.1
|
(G-T test b)
| | | | |
RMST in control
|
5.39
|
3.69
|
2.46
|
2.68
|
arm ()
| | | | |
RMST in research
|
5.28
|
4.02
|
2.79
|
3.13
|
arm ()
| | | | |
Diff.
|
-0.11 (0.10)
|
0.33 (0.18)
|
0.33 (0.17)
|
0.46 (0.26)
|
(SE)
| | | | |
P-value for
|
0.3
|
0.07
|
0.05
|
0.08
|
(RMST test)
| | | | |
P-value for
|
0.07
|
0.4
|
0.7
|
0.04
|
non-PH c
| | | | |
- See text for details.
-
aEvents occurring in the interval (0,t
*).
-
bGrambsch-Therneau test
-
cFrom a flexible parametric hazards model with a time-dependent treatment effect.