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Table 4 Discrimination measures and hazard ratios evaluated in the derivation and validation datasets

From: External validation of a Cox prognostic model: principles and methods

Measure Derivation data Validation data
  Estimate SE Estimate SE
Harrell c-index 0.673 0.009 0.658 0.016
Gönen & Heller K 0.655 0.008 0.645 0.015
Explained variation ( R D 2 ) 0.166 0.017 0.145 0.033
HR: group 2 versus 1 1.58 0.19 1.63 0.35
HR: group 3 versus 1 3.33 0.39 3.34 0.70
HR: group 4 versus 1 4.75 0.60 6.33 1.54
  1. All values are based on the PI of the prognostic model. Risk groups were defined as described in the text. Standard errors (SE) for the c-index and for R D 2 were estimated from 200 bootstrap samples. HR = hazard ratio.