Accuracy of T2 compared to T1 | Parameter value | AUC for T1 and T2 | AUC for T1 | AUC difference | IDI in events | IDI in non events | IDI* | |
---|---|---|---|---|---|---|---|---|
1) Higher sensitivity | S2 = 80, C2 = 90 | True | 0.88 | 0.80 | 0.09 | 0.10 | 0.04 | 0.15 |
Estimated | 0.90 (0.89, 0.90) | 0.80 (0.80, 0.81) | 0.09 (0.08, 0.10) | 0.13 (0.11, 0.15) | 0.06 (0.04, 0.07) | 0.19 (0.16, 0.21) | ||
2) Higher specificity | S2 = 70, C2 = 95 | True | 0.87 | 0.80 | 0.07 | 0.10 | 0.04 | 0.15 |
Estimated | 0.88 (0.87. 0.89) | 0.80 (0.80, 0.81) | 0.07 (0.06, 0.09) | 0.12 (0.10, 0.14) | 0.05 (0.04, 0.06) | 0.17 (0.15, 0.19) | ||
3) Lower sensitivity | S2 = 60, C2 = 90 | True | 0.84 | 0.80 | 0.04 | 0.03 | 0.01 | 0.04 |
Estimated | 0.85 (0.84, 0.86) | 0.80 (0.80, 0.81) | 0.05 (0.04, 0.05) | 0.05 (0.04, 0.06) | 0.02 (0.02, 0.03) | 0.08 (0.06, 0.19) | ||
4) Lower specificity | S2 = 70, C2 = 80 | True | 0.83 | 0.80 | 0.03 | 0.02 | 0.01 | 0.03 |
Estimated | 0.85 (0.84, 0.86) | 0.80 (0.80, 0.81) | 0.04 (0.04, 0.05) | 0.04 (0.03, 0.04) | 0.02 (0.01, 0.02) | 0.06 (0.05, 0.06) | ||
5) Both better | S2 = 80, C2 = 95 | True | 0.90 | 0.80 | 0.11 | 0.17 | 0.07 | 0.24 |
Estimated | 0.91 (0.90, 0.92) | 0.80 (0.79, 0.81) | 0.11 (0.09, 0.12) | 0.19 (0.16, 0.21) | 0.08 (0.07, 0.09) | 0.27 (0.24, 0.29) | ||
6) Both worse | S2 = 60, C2 = 80 | True | 0.82 | 0.80 | 0.02 | 0.01 | 0.00 | 0.01 |
Estimated | 0.84 (0.83, 0.84) | 0.80 (0.80, 0.81) | 0.03 (0.03, 0.04) | 0.02 (0.02, 0.03) | 0.01 (0.007, 0.01) | 0.03 (0.02, 0.04) | ||
7) No better | S2 = 70, C2 = 90 | True | 0.85 | 0.80 | 0.05 | 0.05 | 0.02 | 0.07 |
Estimated | 0.86 (0.85, 0.87) | 0.80 (0.80, 0.81) | 0.06 (0.05, 0.07) | 0.08 (0.07, 0.10) | 0.04 (0.03, 0.04) | 0.12 (0.10, 0.14) | ||
8) No value | S2 = 70, C2 = 30 | True | 0.84 | 0.80 | 0.04 | 0.01 | 0.01 | 0.02 |
Estimated | 0.84 (0.83, 0.86) | 0.80 (0.79, 0.80) | 0.04 (0.03, 0.06) | 0.02 (0.01, 0.02) | 0.01 (0.004, 0.01) | 0.02 (0.02, 0.04) |