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Table 3 Patient clinical and HRQL measurements

From: Measuring health-related quality of life in chronic obstructive pulmonary disease: properties of the EQ-5D-5L and PROMIS-43 short form

Measure No. of missing Total sample [Mean (SD)] GOLD 1 (n = 102) [Mean (SD)] GOLD 2 (n = 353) [Mean (SD)] GOLD 3 (n = 165) [Mean (SD)] GOLD 4 (n = 50) [Mean (SD)] ANOVA RE ratio ANOVA Kruskal-Wallis test
        F-stat   p-value p-value
FACIT-Dyspnea 6 44.6 (8.4) 41.0 (7.9) 43.3 (8.0) 47.6 (8.0) 51.6 (6.9) 31.19 Ref <.0001 <.0001
mMRC dyspnea 60 1.50 (0.99) 1.20 (0.95) 1.38 (0.95) 1.79 (0.95) 1.88 (1.06) 11.71 0.38 <.0001 <.0001
Borg dyspnea (at rest) 55 0.67 (1.08) 0.55 (0.91) 0.60 (1.07) 0.92 (1.19) 0.64 (0.97) 3.52 0.11 0.01 0.02
Borg dyspnea (during 6MWT) 60 2.52 (1.94) 2.07 (1.73) 2.27 (1.90) 3.02 (1.78) 3.78 (2.37) 13.06 0.42 <.0001 <.0001
6MWD 60 335.6 (110.4) 371.9 (111.2) 345.5 (109.4) 301.2 (103.1) 297.8 (101.3) 11.24 0.36 <.0001 <.0001
EQ-5D index 0 0.79 (0.15) 0.81 (0.14) 0.81 (0.14) 0.76 (0.17) 0.74 (0.15) 6.13 0.20 0.0004 0.002
EQ-VAS 0 70.6 (19.6) 76.6 (17.5) 72.6 (19.1) 65.7 (20.2) 61.1 (19.7) 12.24 0.39 <.0001 <.0001
PROMIS           
 Physical function (P-PF) 0 40.6 (7.6) 43.2 (8.2) 41.7 (7.7) 38.3 (6.0) 35.3 (5.5) 21.41 0.69 <.0001 <.0001
 Anxiety (P-A) 0 49.7 (9.2) 49.5 (9.6) 49.3 (9.0) 50.0 (9.4) 52.3 (8.7) 1.69 0.05 0.17 0.15
 Depression (P-D) 0 48.3 (9.3) 49.3 (10.1) 47.3 (8.8) 48.5 (9.6) 51.8 (8.9) 4.08 0.13 0.007 0.01
 Fatigue (P-F) 0 50.8 (9.2) 51.2 (9.9) 50.0 (9.2) 51.3 (8.8) 53.9 (8.4) 3.01 0.10 0.03 0.04
 Sleep disturbance (P-SD) 0 49.8 (9.4) 51.5 (10.2) 49.3 (9.0) 50.0 (9.6) 48.9 (9.4) 1.64 0.05 0.18 0.23
 Social roles (P-SR) 2 48.1 (9.3) 49.3 (9.0) 49.0 (9.4) 46.3 (9.3) 44.7 (7.9) 6.07 0.19 0.0004 0.001
 Pain interference (P-PI) 3 53.9 (9.6) 53.8 (9.5) 54.3 (9.5) 53.3 (9.7) 53.1 (9.8) 0.56 0.02 0.64 0.74
 Pain intensity scale (P-P) 0 3.49 (2.67) 3.49 (2.69) 3.54 (2.62) 3.43 (2.70) 3.28 (2.90) 0.18 0.01 0.91 0.85
  1. 6MWD = six-minute walk distance; 6MWT = six-minute walk test; ANOVA = analysis of variance; GOLD = Global initiative for chronic Obstructive Lung Disease; FACIT = Factional Assessment of Chronic Illness Therapy; mMRC = modified Medical Research Council; PROMIS = Patient Reported Outcomes Measurement Information System; RE = relative efficiency; ref = reference group (RE = 1).