Table 2 Comparison of IPD and APD Meta-Analyses

Explicit and Relevant Clinical Question

Exhaustive Search

All published studies

All presented studies

All completed studies

Screening: inclusion/exclusion criteria

Data Acquisition (extraction/transfer)

Aggregate data

Individual patient data

Data Checking

Source data

Submitted data

Published/presented

Data Updating

Missing Studies/Data

Uniform outcomes

Tests for heterogeneity

Estimating Summary Effect Measures

Binomial data

Time-to-event data

Exploring Heterogeneity Subgroup analyses

Study Level

Patient Level