Simulation parameters1 | Type of imbalance | Bias | Mean Square Error | Empirical type I error2 | Empirical power2 | ||
---|---|---|---|---|---|---|---|
Intraclass correlation coefficient (ρ) | Number of clusters in each arm (g) | Total number of subjects in each arm (N) | Type of imbalance | ||||
0.005 | 5 | 89 | None | 0.0025 | 0.0238 | 0.0190 | 0.7648 |
Moderate | 0.0010 | 0.0243 | 0.0204 | 0.7622 | |||
Poisson | 0.0014 | 0.0243 | 0.0214 | 0.7596 | |||
Pareto | -0.0064 | 0.0393 | 0.0256 | 0.6250 | |||
0.005 | 10 | 73 | None | -0.0011 | 0.0288 | 0.0328 | 0.7660 |
Moderate | -0.0015 | 0.0290 | 0.0322 | 0.7718 | |||
Poisson | -0.0007 | 0.0298 | 0.0318 | 0.7662 | |||
Pareto | -0.0005 | 0.0344 | 0.0352 | 0.7090 | |||
0.005 | 20 | 67 | None | -0.0011 | 0.0303 | 0.0384 | 0.7764 |
Moderate | -0.0038 | 0.0296 | 0.0318 | 0.7700 | |||
Poisson | -0.0012 | 0.0301 | 0.0382 | 0.7664 | |||
Pareto | -0.0004 | 0.0323 | 0.0334 | 0.7322 | |||
0.005 | 40 | 65 | None | 0.0005 | 0.0310 | 0.0446 | 0.7986 |
Moderate | 0.0021 | 0.0322 | 0.0478 | 0.7896 | |||
Poisson | 0.0028 | 0.0305 | 0.0396 | 0.7860 | |||
Pareto | -0.0007 | 0.0320 | 0.0382 | 0.7518 | |||
0.020 | 5 | 119 | None | 0.0025 | 0.0238 | 0.0190 | 0.7648 |
Moderate | -0.0011 | 0.0248 | 0.0310 | 0.7856 | |||
Poisson | -0.0021 | 0.0250 | 0.0306 | 0.7786 | |||
Pareto | 0.0009 | 0.0413 | 0.0674 | 0.6262 | |||
0.020 | 10 | 81 | None | -0.0031 | 0.0273 | 0.0320 | 0.7798 |
Moderate | 0.0006 | 0.0282 | 0.0364 | 0.7772 | |||
Poisson | -0.0003 | 0.0288 | 0.0378 | 0.7778 | |||
Pareto | 0.0078 | 0.0394 | 0.0550 | 0.6910 | |||
0.020 | 20 | 70 | None | 0.0026 | 0.0312 | 0.0476 | 0.7838 |
Moderate | 0.0026 | 0.0312 | 0.0476 | 0.7838 | |||
Poisson | 0.0032 | 0.0306 | 0.0436 | 0.7894 | |||
Pareto | 0.0003 | 0.0362 | 0.0460 | 0.7056 | |||
0.020 | 40 | 66 | None | -0.0026 | 0.0314 | 0.0498 | 0.7878 |
Moderate | 0.0026 | 0.0312 | 0.0476 | 0.7838 | |||
Poisson | 0.0049 | 0.0326 | 0.0476 | 0.7828 | |||
Pareto | -0.0007 | 0.0337 | 0.0422 | 0.7328 | |||
0.050 | 5 | 423 | None | 0.0015 | 0.0246 | 0.0482 | 0.7980 |
Moderate | -0.0001 | 0.0240 | 0.0460 | 0.8004 | |||
Poisson | -0.0005 | 0.0237 | 0.0478 | 0.7988 | |||
Pareto | 0.0026 | 0.0337 | 0.0768 | 0.6808 | |||
0.050 | 10 | 103 | None | -0.0006 | 0.0280 | 0.0426 | 0.7964 |
Moderate | 0.0012 | 0.0286 | 0.0446 | 0.7952 | |||
Poisson | -0.0017 | 0.0293 | 0.0440 | 0.7754 | |||
Pareto | -0.0022 | 0.0466 | 0.0770 | 0.6342 | |||
0.050 | 20 | 76 | None | 0.0027 | 0.0298 | 0.0436 | 0.8020 |
Moderate | -0.0018 | 0.0308 | 0.0452 | 0.7784 | |||
Poisson | -0.0016 | 0.0323 | 0.0526 | 0.7672 | |||
Pareto | -0.0056 | 0.0396 | 0.0528 | 0.6620 | |||
0.050 | 40 | 67 | None | -0.0019 | 0.0313 | 0.0468 | 0.7880 |
Moderate | -0.0012 | 0.0294 | 0.0516 | 0.7740 | |||
Poisson | 0.0000 | 0.0335 | 0.0504 | 0.7712 | |||
Pareto | 0.0022 | 0.0376 | 0.0516 | 0.7026 | |||
0.100 | 10 | 213 | None | 0.0006 | 0.0263 | 0.0426 | 0.8056 |
Moderate | 0.0015 | 0.0289 | 0.0530 | 0.7940 | |||
Poisson | -0.0007 | 0.0287 | 0.0538 | 0.8004 | |||
Pareto | -0.0027 | 0.0438 | 0.0730 | 0.6394 | |||
0.100 | 20 | 89 | None | -0.0029 | 0.0303 | 0.0470 | 0.7888 |
Moderate | -0.0020 | 0.0324 | 0.0530 | 0.7760 | |||
Poisson | -0.0004 | 0.0316 | 0.0488 | 0.7744 | |||
Pareto | 0.0064 | 0.0492 | 0.0674 | 0.6276 | |||
0.100 | 40 | 70 | None | 0.0038 | 0.0331 | 0.0510 | 0.7890 |
Moderate | 0.0031 | 0.0337 | 0.0506 | 0.7738 | |||
Poisson | 0.0020 | 0.0332 | 0.0456 | 0.7658 | |||
Pareto | 0.0019 | 0.0433 | 0.0536 | 0.6641 |