Table 2 Estimates of model parameters using non linear mixed models taking into account left-censored (undetectable) values (corrected) or not (crude) with data from ROCO2 clinical trial. N = 17 patients, 100 measures, 12% left-censored.

V ₀

6.13

5.78; 6.48

6.12

5.77; 6.47

δ

0.13

0.11; 0.17

0.19

0.14; 0.26

c

1.73

1.15; 2.61

1.66

0.88; 3.13

ε

0.89

0.74; 0.96

0.86

0.64; 0.95

${\sigma }_{{\gamma }_0}^2$

0.42

0.082; 0.75

0.41

0.077; 0.74

${\sigma }_{{\gamma }_1}^2$

3.23

0.38; 6.09

3.77

0.38; 7.16

${\sigma }_e^2$

0.071

0.045; 0.097

0.073

0.044; 0.10