Skip to main content

Advertisement

Table 2 Estimates of model parameters using non linear mixed models taking into account left-censored (undetectable) values (corrected) or not (crude) with data from ROCO2 clinical trial. N = 17 patients, 100 measures, 12% left-censored.

From: Estimation of dynamical model parameters taking into account undetectable marker values

Parameter Crude approach Corrected approach
  Estimate 95% CI Estimate 95% CI
V 0 6.13 5.78; 6.48 6.12 5.77; 6.47
δ 0.13 0.11; 0.17 0.19 0.14; 0.26
c 1.73 1.15; 2.61 1.66 0.88; 3.13
ε 0.89 0.74; 0.96 0.86 0.64; 0.95
σ γ 0 2 MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaaiiGacqWFdpWCdaqhaaWcbaGae83SdC2aaSbaaWqaaiabicdaWaqabaaaleaacqaIYaGmaaaaaa@325D@ 0.42 0.082; 0.75 0.41 0.077; 0.74
σ γ 1 2 MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaaiiGacqWFdpWCdaqhaaWcbaGae83SdC2aaSbaaWqaaiabigdaXaqabaaaleaacqaIYaGmaaaaaa@325F@ 3.23 0.38; 6.09 3.77 0.38; 7.16
σ e 2 MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaaiiGacqWFdpWCdaqhaaWcbaGaemyzaugabaGaeGOmaidaaaaa@30E8@ 0.071 0.045; 0.097 0.073 0.044; 0.10