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Table 5 Baseline differences in standard deviations, stratified by diagnosis. Each comparison refers to one SF-36 scale at baseline: Mean score in AMOS cohort minus mean score in corresponding cohort, divided by standard deviation of score in AMOS cohort. A negative difference indicates that AMOS cohorts have worse health status than corresponding cohorts at baseline.

From: Assessing the order of magnitude of outcomes in single-arm cohorts through systematic comparison with corresponding cohorts: An example from the AMOS study

Diagnosis

Median

Interquartile range

Ranges: Number (percentage) of comparisons

N (total)

   

≤ -0.8

-0.79 to -0.5

-0.49 to -0.2

-0.19 to 0.19

0.2 to 0.49

0.5 to 0.79

≥ 0.8

 

Asthma

-0.02

-0.20 to +0.27

0 (0)

4 (5)

15 (20)

34 (44)

17 (22)

7 (9)

0 (0)

77 (100)

Depression

-0.25

-0.51 to +0.03

10 (13)

9 (12)

28 (36)

19 (24)

9 (12)

0 (0)

3 (4)

78 (100)

Low back pain

-0.05

-0.45 to +0.31

15 (7)

30 (15)

38 (19)

58 (29)

32 (16)

15 (7)

14 (7)

202 (100)

Migraine

-0.42

-0.64 to -0.17

28 (19)

36 (24)

48 (32)

31 (21)

6 (4)

1 (1)

0 (0

150 (100)

Neck pain

-0.37

-0.66 to -0.12

1 (10)

3 (30)

2 (20)

3 (30)

0 (0)

1 (10)

0 (0)

10 (100)

Total

-0.22

-0.53 to +0.13

55 (11)

82 (16)

131 (25)

144 (28)

64 (12)

24 (5)

17 (3)

517 (100)