Table 5 Reporting characteristics of the analysis of multiple genetic variants for 315 randomly selected HuGE articles (2001–2003)
From: Reporting of Human Genome Epidemiology (HuGE) association studies: An empirical assessment
Reporting characteristic | Count | Percent |
|---|---|---|
Number of genes analyzed | Â | Â |
   1 | 188 | 59.7 |
   2 | 71 | 22.5 |
   >= 3 | 56 | 17.8 |
Number of genetic variants analyzed | Â | Â |
   1 | 114 | 36.2 |
   2 | 85 | 27.0 |
   3 | 56 | 17.8 |
   4 | 21 | 6.6 |
   >= 5 | 39 | 12.4 |
Reported on linkage disequilibrium (among those studying 2 or more polymorphisms) (n = 201) | Â | Â |
   No | 155 | 77.1 |
   Yes | 46 | 22.9 |
Reported on an analysis using haplotypes (among those studying 2 or more polymorphisms) (n = 201) | Â | Â |
   No | 158 | 78.6 |
   Yes | 43 | 21.4 |
Reported on a interlocus or gene-gene interaction (among those studying 2 or more polymorphisms) (n = 201) | Â | Â |
   No | 152 | 75.6 |
   Yes | 49 | 24.4 |
If interlocus or gene-gene interactions were assessed, was risk quantified as an odds ratio or risk ratio (n = 49) | Â | Â |
   No | 22 | 44.9 |
   Yes | 27 | 55.1 |
If interlocus or gene-gene interactions were assessed, was risk quantified as an absolute difference (n = 49) | Â | Â |
   No | 47 | 95.9 |
   Yes | 2 | 4.1 |
If interlocus or gene-gene interactions were assessed, was risk quantified as an attributable fraction (n = 49) | Â | Â |
   No | 49 | 100.0 |
   Yes | 0 | 0.0 |
If interlocus or gene-gene interactions were assessed, claim was made of a statistically significant interaction (n = 49) | Â | Â |
   No | 24 | 49.0 |
   Yes | 25 | 51.0 |