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Table 5 Reporting characteristics of the analysis of multiple genetic variants for 315 randomly selected HuGE articles (2001–2003)

From: Reporting of Human Genome Epidemiology (HuGE) association studies: An empirical assessment

Reporting characteristic Count Percent
Number of genes analyzed   
   1 188 59.7
   2 71 22.5
   >= 3 56 17.8
Number of genetic variants analyzed   
   1 114 36.2
   2 85 27.0
   3 56 17.8
   4 21 6.6
   >= 5 39 12.4
Reported on linkage disequilibrium (among those studying 2 or more polymorphisms) (n = 201)   
   No 155 77.1
   Yes 46 22.9
Reported on an analysis using haplotypes (among those studying 2 or more polymorphisms) (n = 201)   
   No 158 78.6
   Yes 43 21.4
Reported on a interlocus or gene-gene interaction (among those studying 2 or more polymorphisms) (n = 201)   
   No 152 75.6
   Yes 49 24.4
If interlocus or gene-gene interactions were assessed, was risk quantified as an odds ratio or risk ratio (n = 49)   
   No 22 44.9
   Yes 27 55.1
If interlocus or gene-gene interactions were assessed, was risk quantified as an absolute difference (n = 49)   
   No 47 95.9
   Yes 2 4.1
If interlocus or gene-gene interactions were assessed, was risk quantified as an attributable fraction (n = 49)   
   No 49 100.0
   Yes 0 0.0
If interlocus or gene-gene interactions were assessed, claim was made of a statistically significant interaction (n = 49)   
   No 24 49.0
   Yes 25 51.0