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Table 7 Comparison of the reporting characteristics of HuGE articles from two time periods (2001–2003 vs. 2006)

From: Reporting of Human Genome Epidemiology (HuGE) association studies: An empirical assessment

  Published from 2001–2003 Published in 2006  
Reporting characteristic Count Percent Count Percent P-Valuea
Basic descriptive items
Number of study participants      
   < 100 49 15.6 5 17.9 0.90
   100–499 190 60.3 16 57.1  
   500–999 47 14.9 4 14.3  
   >= 1000 29 9.2 3 10.7  
Number of genes analyzed      
   1 188 59.7 21 75.0 0.12
   2 71 22.5 4 14.3  
   >= 3 56 17.8 3 10.7  
Number of genetic variants analyzed      
   1 114 36.2 10 35.7 0.29
   2 85 27.0 4 14.3  
   3 56 17.8 6 21.4  
   4 21 6.6 1 3.6  
   >= 5 39 12.4 7 25.0  
Number of environmental factors examined in gene-environment interactions      
   1 34 70.8 1 50.0 0.26
   2 10 20.8 1 50.0  
   >= 3 4 8.4 0 0.0  
Items applicable to all articles that were addressed in less than 50% of the 2001–2003 HuGE articles
Reported the available power of the study      
   No 275 87.3 20 71.4 0.03
   Yes 40 12.7 8 28.6  
Explicitly stated the use of unrelated study participants      
   No 259 82.2 18 64.3 0.03
   Yes 56 17.8 10 35.7  
Reported that genotyping results were validated using duplicate samples      
   No 293 93.0 22 78.6 0.02
   Yes 22 7.0 6 21.4  
Reported that genotyping results were validated using a different method      
   No 284 90.2 24 85.7 0.32
   Yes 31 9.8 4 14.3  
Reported that the evaluation of the genetic test was blind to outcomes or phenotypes      
   Blind 35 11.1 3 10.7 0.62
   Unclear 280 88.9 25 89.3  
Reported that the evaluation of the outcomes or phenotypes was blind to the genetic test      
   Blind 12 3.8 2 7.1 0.32
   Unclear 303 96.2 26 92.9  
Reported that individuals were excluded from the original group(s) of study participants      
   No 278 88.2 26 92.9 0.86
   Yes 37 11.8 2 7.1  
Reported that several samples could not be genotyped      
   No 266 84.4 23 82.1 0.46
   Yes 49 15.6 5 17.9  
Reported that unlinked genetic markers were used to identify population stratification      
   No 313 99.4 28 100.0 1.00
   Yes 2 0.6 0 0.0  
Reported that all genetic variants were examined for Hardy-Weinberg equilibrium      
   No 164 52.1 12 42.9 0.23
   Yes 151 47.9 16 57.1  
  1. a P-values were determined from two-sided Mann-Whitney U tests for the basic descriptive items and one sided Fisher's Exact Tests for the items that were reported in less than 50% of the 2001–2003 articles.