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Table 2 Regions of significance and voting for a positive treatment effect in three uncontrolled studies on Bosentan in PAH based on the approach presented in this paper

From: Regression toward the mean – a detection method for unknown population mean based on Mee and Chua's algorithm

Study N 6MWD at Baseline 6MWD at week 16 correlation region of significance Vote of significance
Souza et al. 2005 [18] 15 396 ± 135 434 ± 137 r = 0.2 [0;337] & [672;∞] Unlikely
     r = 0.5 [0;300] Unlikely
     r = 0.8 - Never
Provencher et al. 2006 [19] 99 322 ± 105 364 ± 109 r = 0.2 [0;347] & [410;∞] Probably
     r = 0.5 [0;367] & [481;∞] Probably
     r = 0.8 [0;448] & [1292;∞] Most likely
Apostolopoulou et al. 2006 [20] 21 416 ± 105 459 ± 101 r = 0.2 [0;412] & [575;∞] Unlikely
     r = 0.5 [0;420] & [820;∞] Unlikely
     r = 0.8 [0;466] Probably
  1. (N- number of patients, 6MWT-6-minute walk distance, data before and after intervention is mean ± standard deviation, region of significance: only 6MWD values > 0 reported)