Table 2 Regions of significance and voting for a positive treatment effect in three uncontrolled studies on Bosentan in PAH based on the approach presented in this paper
Study | N | 6MWD at Baseline | 6MWD at week 16 | correlation | region of significance | Vote of significance |
|---|---|---|---|---|---|---|
Souza et al. 2005 [18] | 15 | 396 ± 135 | 434 ± 137 | r = 0.2 | [0;337] & [672;∞] | Unlikely |
r = 0.5 | [0;300] | Unlikely | ||||
r = 0.8 | - | Never | ||||
Provencher et al. 2006 [19] | 99 | 322 ± 105 | 364 ± 109 | r = 0.2 | [0;347] & [410;∞] | Probably |
r = 0.5 | [0;367] & [481;∞] | Probably | ||||
r = 0.8 | [0;448] & [1292;∞] | Most likely | ||||
Apostolopoulou et al. 2006 [20] | 21 | 416 ± 105 | 459 ± 101 | r = 0.2 | [0;412] & [575;∞] | Unlikely |
r = 0.5 | [0;420] & [820;∞] | Unlikely | ||||
r = 0.8 | [0;466] | Probably |