M1
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Aggregate data only
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Aggregates the IPD and includes observational data through random effects on change from baseline 6MWD
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2.1
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M2
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Aggregate and IPD
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Extends M1 to combine aggregate data and IPD
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2.2
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M3
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Aggregate and IPD
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Extends M2 to include covariate adjustments on change from baseline 6MWD
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2.3
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M4
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Aggregate and IPD
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Extends M3 to include interactions between treatment effect and covariates
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2.4
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S1
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Aggregate and IPD
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Same as M4 but SE in observational studies are inflated by a factor of 10 to downweight their evidence
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3.3
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S2
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Aggregate and IPD
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Same as M4 but constructed a control arm for observational studies where all patients assumed to deteriorate by 25 m from baseline in 6MWD
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3.4
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