Table 5 Summary of NMA models used for comparison of treatment combinations for PAH synthesising aggregate data from the literature and IPD from IMPRES study
Model | Data | Description | Section with model details |
|---|---|---|---|
M1 | Aggregate data only | Aggregates the IPD and includes observational data through random effects on change from baseline 6MWD | 2.1 |
M2 | Aggregate and IPD | Extends M1 to combine aggregate data and IPD | 2.2 |
M3 | Aggregate and IPD | Extends M2 to include covariate adjustments on change from baseline 6MWD | 2.3 |
M4 | Aggregate and IPD | Extends M3 to include interactions between treatment effect and covariates | 2.4 |
S1 | Aggregate and IPD | Same as M4 but SE in observational studies are inflated by a factor of 10 to downweight their evidence | 3.3 |
S2 | Aggregate and IPD | Same as M4 but constructed a control arm for observational studies where all patients assumed to deteriorate by 25 m from baseline in 6MWD | 3.4 |