| Complete patient data (N = 82,887) | Aggregated quarterly-clinic data (N = 1,518) | Case–control study (N = 5,000) | Two-phase studyd | ||||||
---|---|---|---|---|---|---|---|---|---|---|
Design #1 (N = 5,000) | Design #2 (N = 5,000) | |||||||||
 | OR | 95% CI | OR | 95% CI | OR | 95% CI | OR | 95% CI | OR | 95% CI |
Age a | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 Linear | 0.96 | (0.94, 0.98) | 0.35 | (0.19, 0.66) | 0.94 | (0.25, 0.52) | 0.94 | (0.87, 1.01) | 0.88 | (0.80, 0.95) |
 Quadratic | 1.06 | (1.05, 1.07) | 0.77 | (0.54, 1.10) | 1.05 | (0.88, 1.00) | 1.04 | (0.99, 1.08) | 1.03 | (0.98, 1.08) |
Gender | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 Male | REF |  | REF |  | REF |  | REF |  | REF |  |
 Femaleb | 0.72 | (0.69, 0.74) | 0.87 | (0.82, 0.93) | 0.75 | (0.66, 0.84) | 0.76 | (0.67, 0.87) | 0.71 | (0.62, 0.82) |
WHO stage | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 1/2 | REF |  | REF |  | REF |  | REF |  | REF |  |
 3/4c | 3.33 | (2.97, 3.74) | 1.57 | (1.44, 1.72) | 3.69 | (2.62, 5.20) | 3.31 | (2.41, 4.55) | 4.31 | (2.87, 6.46) |
Region | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 Central/North | REF |  | REF |  | REF |  | REF |  | REF |  |
 South | 0.92 | (0.88, 0.95) | 0.88 | (0.82, 0.93) | 0.93 | (0.83, 1.05) | 0.91 | (0.80, 1.04) | 1.02 | (0.88, 1.17) |
Year of registration | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 2005 | REF |  | REF |  | REF |  | REF |  | REF |  |
 2006 | 0.91 | (0.87, 0.95) | 1.00 | (0.94, 1.07) | 0.97 | (0.83, 1.05) | 0.83 | (0.68, 1.01) | 0.88 | (0.83, 0.93) |
 2007 | 0.76 | (0.73, 0.80) | 0.91 | (0.85, 0.97) | 0.74 | (0.63, 0.86) | 0.75 | (0.62, 0.91) | 0.75 | (0.71, 0.80) |
Clinic type | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 Public | REF |  | REF |  | REF |  | REF |  | REF |  |
 Private | 0.31 | (0.20, 0.48) | 1.08 | (0.99, 1.19) | 0.39 | (0.13, 1.14) | 0.31 | (0.19, 0.50) | 0.31 | (0.20, 0.47) |
Clinic/year interaction | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 Private/2006 | 2.16 | (1.35, 3.46) | 2.03 | (0.95, 4.35) | 2.20 | (0.67, 7.28) | 2.18 | (1.30, 3.67) | 2.20 | (1.37, 3.53) |
 Private/2007 | 2.05 | (1.26, 3.32) | 1.98 | (0.91, 4.32) | 2.36 | (0.69, 8.05) | 2.07 | (1.21, 3.52) | 1.98 | (1.22, 3.21) |