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Table 2 The use of systematic reviews in trial design

From: Using systematic reviews to inform NIHR HTA trial planning and design: a retrospective cohort

Reasons Cohort I No. of applications (%) Cohort II No. of applications (%)
(n = 42) (n = 34)
Adverse events 7 (16.6) 1 (2.9)
Choice of frequency/dose 2 (4.7) 1 (2.9)
Duration of follow-up 1 (2.3) 2 (5.8)
Estimating the control group event rate 2 (4.7) 0 (0)
Estimating the difference to detect or margin of equivalence 2 (4.7) 1 (2.9)
Inform standard deviation 0 (0) 3 (8.8)
Intensity of interventions 1 (2.3) 1 (2.9)
Justification of prevalence 3 (7.1) 0 (0)
Justification of treatment comparison 38 (90.4) 32 (94.1)
Recruitment and consent 4 (9.5) 1 (2.9)
Route of intervention 0 (0) 1 (2.9)
Selection of definition or outcome 5 (11.9) 5 (16.1)
Withdrawal rate 1 (2.3) 0 (0)