A new statistical method for curve group analysis of longitudinal gene expression data illustrated for breast cancer in the NOWAC postgenome cohort as a proof of principle

Table 3 P-values obtained when testing whether there are more genes in the curve groups than what is expected by chance in different strata

p-value
Curve group	Screen-detected cancers with spread	Screen-detected cancers without spread	Interval cancers with spread	Interval cancers without spread	Clinical cancers with spread	Clinical cancers without spread
Global	0.36	0.43	0.02*	0.46	0.40	0.81
123	0.10	0.33	0.21	0.89	0.06	0.34
132	0.38	0.19	0.009*	0.32	0.51	0.63
312	0.83	0.30	0.07	0.21	0.98	0.81
321	0.18	0.90	0.05*	0.40	0.22	0.66
231	0.33	0.63	0.21	0.83	0.94	0.93
213	0.70	0.27	0.29	0.16	0.90	0.59