Table 1 Characteristics of the hospital-based pediatric studies sponsored by the Assistance Publique-Hôpitaux de Paris between 2002 and 2008
From: Academic pediatric clinical research: factors associated with study implementation duration
Characteristics | Observational studies (n = 72) | Interventional studies without drug therapy (n = 32) | Interventional studies involving drug therapy (n = 35) | p-value | Excluded studies (n = 6) | |
|---|---|---|---|---|---|---|
NA | ||||||
Funding mechanism | 0.07 | 5 | ||||
Government | 39 (54) | 20 (63) | 12 (34) | 1 (100) | ||
External | 20 (28) | 4 (13) | 14 (40) | 0 (0) | ||
Internal | 13 (18) | 8 (25) | 9 (26) | 0 (0) | ||
Year of grant | - | 0 | ||||
2002 | 17 (24) | 1 (3) | 3 (9) | 1 (17) | ||
2003 | 5 (7) | 2 (6) | 3 (9) | 4 (67) | ||
2004 | 9 (13) | 2 (6) | 5 (14) | 1 (17) | ||
2005 | 15 (21) | 1 (3) | 7 (20) | 0 | ||
2006 | 6 (8) | 5 (16) | 6 (17) | 0 | ||
2007 | 12 (17) | 12 (38) | 9 (26) | 0 | ||
2008 | 8 (11) | 9 (28) | 2 (6) | 0 | ||
Coordinator center | 0.31 | 0 | ||||
Pediatric hospital | 28 (39) | 15 (47) | 19 (54) | 6 (100) | ||
General hospital | 44 (61) | 17 (53) | 16 (46) | 0 (0) | ||
Number of centers | 6 [2;16] | 5 [2;16] | 3 [1;15] | 0.78 | 1 [1;1] | 1 |
Monocentric study | 12 (17) | 5 (15.6) | 14 (40) | 0.01 | 4 (80) | 1 |
International study | 1 (1) | 0 (0) | 4 (11) | 0.006 | 0 (0) | 0 |
Rare disease | 50 (69) | 20 (63) | 27 (77) | 0.43 | 4 (67) | 0 |
Chronic disease | 60 (83) | 22 (69) | 26 (74) | 0.22 | 4 (67) | 0 |
Study population | 0.003 | 0 | ||||
Pediatric | 30 (42) | 19 (59) | 27 (77) | 6 (100) | ||
Mixed (children and adults) | 42 (58) | 13 (41) | 8 (23) | 0 (0) | ||
Number of patients to include | 150 [82;388] | 128 [66;240] | 60 [36;100] | 0.12 | 20 [20;25] | 3 |
Length of participation, months | 0.2 [0.03;12] | 4 [0.2;17] | 8 [0.5;24] | 0.61 | 0.1 [0.03;2] | 2 |
Referenced in ClinicalTrials.gov | 21 (29) | 32 (100) | 24 (69) | <0.001 | 1 (17) | 0 |