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Table 4 Difficulties in clinical research by study characteristicsa

From: Patient enrollment and logistical problems top the list of difficulties in clinical research: a cross-sectional survey

  Study characteristics
  Privatebsponsorship Public sponsorship   Multi center Single center   Otherc Clinicald  
Difficulties with: % % p % % p % % p
Literature review (get relevant articles, read, synthesize) 2.4 6.9 0.19 3.1 7.9 0.078 7.2 4.9 0.39
Research question (formulation of a main research question and/or hypothesis) 1.2 13.1 0.001 3.2 15.0 <0.001 15.1 5.9 0.004
Study design (identification of the study design, variables, instruments, analysis, including calculation of the sample size) 2.4 25.8 <0.001 8.2 29.1 <0.001 23.3 18.0 0.21
Approval by the Research Ethics Committee 12.2 17.9 0.25 11.9 20.3 0.038 12.8 20.4 0.056
Getting funding 3.7 23.9 <0.001 13.8 23.1 0.026 19.0 19.5 1.00
Approval by the safety agencies (Swiss Agency for Therapeutic Products, etc.) 17.3 8.3 0.023 14.6 7.0 0.024 3.9 15.7 <0.001
Patients enrollment 51.3 41.5 0.13 48.1 42.5 0.30 37.1 51.5 0.005
Data collection 19.5 28.9 0.12 22.0 30.0 0.10 26.1 27.2 0.82
Collaboration with caregivers for patient enrollment 18.3 22.1 0.54 20.1 21.8 0.80 19.4 22.5 0.53
Recruitment of competent persons to conduct the study 12.2 22.0 0.059 16.4 22.9 0.12 16.7 23.3 0.13
Data management 6.1 20.4 0.002 10.1 21.8 0.002 19.6 14.6 0.22
Data analysis (statistical or other) and results interpretation 3.7 26.7 <0.001 10.8 29.3 <0.001 23.5 20.1 0.46
Writing a manuscript for a scientific publication 1.2 23.8 <0.001 8.9 25.6 <0.001 20.9 16.7 0.36
Publication in a peer-reviewed journal 4.9 25.5 <0.001 14.6 24.8 0.020 21.1 20.0 0.80
Other(s) difficulty(ies) 3.7 5.8 0.58 5.0 5.3 1.00 8.9 1.9 0.002
  1. aSelected from the multivariable model (Table 3). P-values come from the Fisher’s exact test
  2. bIndustry or foundation
  3. cHealth/illness, public health, methodology, etc
  4. dIntervention or diagnosis or prognosis