Table 1 Previous studies reporting adherence to HU treatment in SCA
Author, Year | Study design | Sample size and population | Adherence assessment method | % adherence |
|---|---|---|---|---|
Thornburg et al., 2010 [12] | Single site, cross sectional | 75 (3.5–17.8 years) | Visit adherence, Morisky score, provider report, Pharmacy-refill | 82, 84, 77, 49 respectively |
Thornburg et al., 2010 [13] | Multisite randomized controlled trial (Baby HUG) | 153, 9 months–1.5 years | 80 % of liquid medication taken by volume remaining at study visit | 89 |
Ware et al., 2002 [10] | Multisite randomized controlled trial (HUG-KIDS) | 53, 5–15 years | Pill count | 94 |
Kinney et al., 1999 [9] | Multisite randomized controlled trial (HUG-KIDS) | 84, 5–15 y ears | Pill count | 74 |
Candrilli et al., (2011) [4] | Retrospective insurance claims | 312, mean age 21 years | Medication possession ratio | 35 |