Table 1 Simulation scenarios
Scenarios | Effect size | Censoring rate | |||
|---|---|---|---|---|---|
α | β j | γ j | T− | T+ | |
(1) Complete null | 0 | 0 | 0 | 0.72 | 0.72 |
(2) Treatment effect only | − 0.8 | 0 | 0 | 0.62 | 0.80 |
(3) 20 prognostic markers | 0 | ~ U(−0.05, − 0.20) | 0 | 0.70 | 0.70 |
(4) 15 treatment-effect modifiers | 0 | 0 | ~ U(−0.10, − 0.40) | 0.71 | 0.71 |
(5) Treatment effect + (4) | − 0.8 | 0 | ~ U(−0.10, − 0.40) | 0.61 | 0.78 |
(6) 20 prognostic markers + (5) | − 0.8 | ~ U(−0.05, − 0.20) | ~ U(−0.10, − 0.40) | 0.60 | 0.76 |