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Table 1 Simulation scenarios

From: Robust estimation of the expected survival probabilities from high-dimensional Cox models with biomarker-by-treatment interactions in randomized clinical trials

Scenarios Effect size Censoring rate
α β j γ j T T+
(1) Complete null 0 0 0 0.72 0.72
(2) Treatment effect only − 0.8 0 0 0.62 0.80
(3) 20 prognostic markers 0 U(−0.05, − 0.20) 0 0.70 0.70
(4) 15 treatment-effect modifiers 0 0 U(−0.10, − 0.40) 0.71 0.71
(5) Treatment effect + (4) − 0.8 0 U(−0.10, − 0.40) 0.61 0.78
(6) 20 prognostic markers + (5) − 0.8 U(−0.05, − 0.20) U(−0.10, − 0.40) 0.60 0.76
  1. T+: experimental arm, T: control arm