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Fig. 3 | BMC Medical Research Methodology

Fig. 3

From: Design considerations and analysis planning of a phase 2a proof of concept study in rheumatoid arthritis in the presence of possible non-monotonicity

Fig. 3

Receiver operating characteristic ROC curve display the true positive rate (statistical power) and false positive rate for Bayesian Emax (red) and NDLM model (blue) under Fixed design (S1). Bayesian Emax (blue dashed line) and NDLM model (red solid line) and dose response following a U-Shaped, b Emax or c Loglinear curve

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