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Table 2 Overall and treatment strategy-specific subgroup definitions, sample sizes, and number of events for the case study

From: Accounting for parameter uncertainty in the definition of parametric distributions used to describe individual patient variation in health economic models

  Sample size Event observations
Progression (Post-induction) Death (Post-induction) Progression (Re-induction) Death (Re-induction) Death (Salvage)
Subgroup 0: No Subgroups 558 519 39 370 109 410
Observation 279 270 9 200 54 216
Maintenance 279 249 30 170 55 194
Subgroup 1: SD 191 185 6 128 43 142
Observation 95 95 0 68 22 73
Maintenance 96 90 6 60 21 69
Subgroup 2: CR/PR 367 334 33 242 66 268
Observation 184 175 9 132 32 143
Maintenance 183 159 24 110 34 125
Subgroup 3: Synchronous 410 382 28 275 82 300
Observation 191 186 5 143 33 153
Maintenance 219 196 23 132 49 147
Subgroup 4: Metachronous 147 137 10 95 27 110
Observation 88 84 4 57 21 63
Maintenance 59 53 6 38 6 47
Subgroup 5: SD & Synchronous 141 136 5 94 34 102
Observation 67 67 0 49 15 52
Maintenance 74 69 5 45 19 50
Subgroup 6: SD & Metachronous 50 49 1 34 9 40
Observation 28 28 0 19 7 21
Maintenance 22 21 1 15 2 19
Subgroup 7: CR/PR & Synchronous 269 246 23 181 48 198
Observation 124 119 5 94 18 101
Maintenance 145 127 18 87 30 97
Subgroup 8: CR/PR & Metachronous 97 88 9 61 18 70
Observation 60 56 4 38 14 42
Maintenance 37 32 5 23 4 28
  1. SD stable disease, CR/PR complete or partial response