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Table 5 Results of Simulations for Scenario 3

From: A comparison of estimators from self-controlled case series, case-crossover design, and sequence symmetry analysis for pharmacoepidemiological studies

  Setting Results of simulations
Methods (Effect measures) β X Et C (Days)a β C2C3 Mean of estimates (Ratio scale) Bias (Log scale) Empirical standard error Mean squared error Mean standard error Coverage (%)
SCCS (IRR) log(1.0) 15 log(5.0) 1.43 0.3587 0.1255 0.1445 0.1214 18.7
CCO (OR)     1.45 0.3691 0.1979 0.1754 0.1981 53.6
SSA (ASR)     1.04 0.0432 0.2104 0.0461 0.2077 94.5
SCCS (IRR) log(3.0)    4.32 0.3656 0.0719 0.1388 0.0711 0.3
CCO (OR)     4.37 0.3762 0.1720 0.1711 0.1696 39.6
SSA (ASR)     3.12 0.0392 0.1735 0.0316 0.1704 94.5
SCCS (IRR) log(10.0)    14.43 0.3664 0.0427 0.1361 0.0413 0.0
CCO (OR)     14.38 0.3632 0.1612 0.1579 0.1598 36.9
SSA (ASR)     10.18 0.0178 0.1589 0.0256 0.1557 95.4
SCCS (IRR) log(3.0) 5   3.18 0.0584 0.0923 0.0119 0.0910 87.7
CCO (OR)     3.23 0.0730 0.1870 0.0403 0.1913 94.9
SSA (ASR)     3.11 0.0344 0.2224 0.0506 0.2152 94.9
SCCS (IRR)   10   3.67 0.2021 0.0803 0.0473 0.0806 30.0
CCO (OR)     3.73 0.2185 0.1799 0.0801 0.1799 79.3
SSA (ASR)     3.12 0.0385 0.1898 0.0375 0.1920 95.2
SCCS (IRR)   20   4.94 0.4978 0.0640 0.2519 0.0638 0.0
CCO (OR)     4.73 0.4562 0.1545 0.2320 0.1578 14.0
SSA (ASR)     3.09 0.0299 0.1585 0.0260 0.1531 94.2
SCCS (IRR)   30   5.85 0.6673 0.0542 0.4482 0.0543 0.0
CCO (OR)     4.51 0.4075 0.1320 0.1834 0.1323 10.5
SSA (ASR)     3.05 0.0162 0.1296 0.0171 0.1309 95.3
SCCS (IRR)   15 log(0.2) 3.06 0.0195 0.0976 0.0099 0.0947 93.7
CCO (OR)     3.08 0.0267 0.2001 0.0409 0.1949 94.6
SSA (ASR)     3.05 0.0174 0.2276 0.0521 0.2229 94.3
SCCS (IRR)    log(0.5) 3.16 0.0528 0.0944 0.0117 0.0924 89.1
CCO (OR)     3.21 0.0685 0.1979 0.0438 0.1932 94.1
SSA (ASR)     3.10 0.0340 0.2236 0.0511 0.2187 95.1
SCCS (IRR)    log(2.0) 3.61 0.1843 0.0857 0.0413 0.0833 40.4
CCO (OR)     3.67 0.2010 0.1859 0.0750 0.1838 82.7
SSA (ASR)     3.09 0.0281 0.2006 0.0410 0.1971 95.3
  1. Abbreviations ASR Adjusted sequence ratio, CCO Case-crossover, IRR Incident rate ratio, OR Odds ratio, SCCS Self-controlled case series, SSA Sequence symmetry analysis
  2. aLength of the period in which the time-varying covariate C3(t) has an effect