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Table 5 Results of Simulations for Scenario 3

From: A comparison of estimators from self-controlled case series, case-crossover design, and sequence symmetry analysis for pharmacoepidemiological studies

 

Setting

Results of simulations

Methods (Effect measures)

β X

Et C (Days)a

β C2C3

Mean of estimates (Ratio scale)

Bias (Log scale)

Empirical standard error

Mean squared error

Mean standard error

Coverage (%)

SCCS (IRR)

log(1.0)

15

log(5.0)

1.43

0.3587

0.1255

0.1445

0.1214

18.7

CCO (OR)

   

1.45

0.3691

0.1979

0.1754

0.1981

53.6

SSA (ASR)

   

1.04

0.0432

0.2104

0.0461

0.2077

94.5

SCCS (IRR)

log(3.0)

  

4.32

0.3656

0.0719

0.1388

0.0711

0.3

CCO (OR)

   

4.37

0.3762

0.1720

0.1711

0.1696

39.6

SSA (ASR)

   

3.12

0.0392

0.1735

0.0316

0.1704

94.5

SCCS (IRR)

log(10.0)

  

14.43

0.3664

0.0427

0.1361

0.0413

0.0

CCO (OR)

   

14.38

0.3632

0.1612

0.1579

0.1598

36.9

SSA (ASR)

   

10.18

0.0178

0.1589

0.0256

0.1557

95.4

SCCS (IRR)

log(3.0)

5

 

3.18

0.0584

0.0923

0.0119

0.0910

87.7

CCO (OR)

   

3.23

0.0730

0.1870

0.0403

0.1913

94.9

SSA (ASR)

   

3.11

0.0344

0.2224

0.0506

0.2152

94.9

SCCS (IRR)

 

10

 

3.67

0.2021

0.0803

0.0473

0.0806

30.0

CCO (OR)

   

3.73

0.2185

0.1799

0.0801

0.1799

79.3

SSA (ASR)

   

3.12

0.0385

0.1898

0.0375

0.1920

95.2

SCCS (IRR)

 

20

 

4.94

0.4978

0.0640

0.2519

0.0638

0.0

CCO (OR)

   

4.73

0.4562

0.1545

0.2320

0.1578

14.0

SSA (ASR)

   

3.09

0.0299

0.1585

0.0260

0.1531

94.2

SCCS (IRR)

 

30

 

5.85

0.6673

0.0542

0.4482

0.0543

0.0

CCO (OR)

   

4.51

0.4075

0.1320

0.1834

0.1323

10.5

SSA (ASR)

   

3.05

0.0162

0.1296

0.0171

0.1309

95.3

SCCS (IRR)

 

15

log(0.2)

3.06

0.0195

0.0976

0.0099

0.0947

93.7

CCO (OR)

   

3.08

0.0267

0.2001

0.0409

0.1949

94.6

SSA (ASR)

   

3.05

0.0174

0.2276

0.0521

0.2229

94.3

SCCS (IRR)

  

log(0.5)

3.16

0.0528

0.0944

0.0117

0.0924

89.1

CCO (OR)

   

3.21

0.0685

0.1979

0.0438

0.1932

94.1

SSA (ASR)

   

3.10

0.0340

0.2236

0.0511

0.2187

95.1

SCCS (IRR)

  

log(2.0)

3.61

0.1843

0.0857

0.0413

0.0833

40.4

CCO (OR)

   

3.67

0.2010

0.1859

0.0750

0.1838

82.7

SSA (ASR)

   

3.09

0.0281

0.2006

0.0410

0.1971

95.3

  1. Abbreviations ASR Adjusted sequence ratio, CCO Case-crossover, IRR Incident rate ratio, OR Odds ratio, SCCS Self-controlled case series, SSA Sequence symmetry analysis
  2. aLength of the period in which the time-varying covariate C3(t) has an effect
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BMC Medical Research Methodology

ISSN: 1471-2288

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