Evaluating screening approaches for hepatocellular carcinoma in a cohort of HCV related cirrhosis patients from the Veteran’s Affairs Health Care System

Table 2 Comparison of the patient-level true positive rate (TPR(·,τ₁,τ₂)) when the threshold for each screening algorithm was chosen such that the screening-level false positive rate is 10%, i.e FPR(·,τ₁)=0.1. In each definition, the choice of the parameters τ₁ and τ₂ varies

	Results from validation cohort
Screening algorithm	A1	B1	C1	D1	A2	B2	C2	D2
AFP only	0.5753	0.5672	0.5442	0.5388	0.4019	0.4099	0.3564	0.3361
AFP+Lab+ ΔAFP	0.6137	0.6119	0.5907	0.5809	0.4766	0.4820	0.4158	0.3770
PEB: AFP	0.6055	0.6045	0.6023	0.6364	0.4579	0.4955	0.4653	0.4891
Number of HCC cases	365	402	430	451	107	222	303	366

A1: τ₁=6 months and τ₂=0, B1: τ₁=12 months and τ₂=0, C1: τ₁=24 months and τ₂=0, D1: τ₁ is the maximum follow-up time and τ₂=0. A2: τ₁=6 months and τ₂=3 months, B2: τ₁=12 months and τ₂=3 months, C2: τ₁=24 months and τ₂=3 months, D2: τ₁ is the maximum follow-up time and τ₂=3 months. AFP+Lab+ ΔAFP: updated laboratory-based algorithm, PEB: AFP: parametric empirical Bayes algorithm applied to AFP

ISSN: 1471-2288