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Fig. 2 | BMC Medical Research Methodology

Fig. 2

From: Simulation-based power calculations for planning a two-stage individual participant data meta-analysis

Fig. 2

Simulation-based power estimates (based on 10,000 replications) for the planned IPD random effects meta-analysis* of 24 trials for detecting a treatment-BMI interaction when the true effect was − 0.1, conditional on a range of values of the between-study standard deviation (τ λ ) of the interaction effect, when either correctly analysing BMI as continuous or when wrongly analysing BMI as binary (≥ 30 versus < 30). *Based on using change score model (4) in each trial followed by random effects meta-analysis model (9). Standard = DerSimonian and Laird estimation, with p-values and CIs derived using standard normal-based method; HKSJ = DerSimonian and Laird estimation, with p-values and CIs derived using approach of Hartung-Knapp Sidik-Jonkman

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BMC Medical Research Methodology

ISSN: 1471-2288

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