|
n
ik
|
piP, piS
|
Δ
|
contrast-based
|
arm-based
|
|---|
|
1000
|
0.2
|
log(0.9)
|
0.024
|
0.024
|
| | |
log(1)
|
0.024
|
0.024
|
| | |
log(1.1)
|
0.024
|
0.025
|
|
200
|
0.1
|
log(0.9)
|
0.023
|
0.025
|
| | |
log(0.95)
|
0.022
|
0.025
|
| | |
log(1)
|
0.022
|
0.026
|
| | |
log(1.05)
|
0.021
|
0.025
|
| | |
log(1.1)
|
0.023
|
0.026
|
|
400
|
0.05
|
log(0.5)
|
0.032
|
0.024
|
| | |
log(2)
|
0.017
|
0.028
|
- nik denotes the number of treatment arms, piP and piS the success rates in arm P and S, respectively, in trial i (i=1,…,16), and Δ is the non-inferiority or superiority margin, respectively. We used 50,000 simulated data sets to estimate the type I error rate. The nominal level of α was 0.025
