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Table 1 Modified Preventability Algorithm [24]

From: Methods for evaluating adverse drug event preventability in emergency department patients

Definitely Preventable ADE
 1. Was there a history of allergy or previous reactions to the drug or drug class? Yes/No/Uncertain
 -If yes, was the re exposure inappropriate?a* Yes/No/Uncertain
 2. Was any drug involved inappropriate for the patient’s clinical condition?a Yes/No/Uncertain
 3. Was the dose, route or frequency of administration inappropriate for the patient’s age, weight or disease state?a Yes/No/Uncertain
 4.Was a toxic serum drug concentration (or laboratory monitoring test) documented?a Yes/No/Uncertain
 5. Was there a known treatment for the ADE? (eg. To prevent predictable drug side effects)a Yes/No/Uncertain
Probably Preventable ADE
 6. Was required therapeutic drug monitoring or other necessary tests not performed?b Yes/No/Uncertain
 7. Was a drug interaction involved in the ADE?b Yes/No/Uncertain
 8. Was poor compliance involved in the ADE?b Yes/No/Uncertain
 9. Were preventative measures not prescribed or administered to the patient? (eg. Untreated indication?) Yes/No/Uncertain
 -If yes, were preventative measures not contraindicated?b* Yes/No/Uncertain
Additional Criteria for ADE Preventability
 10. Was there an error in ADE diagnosis that contributed to the event persisting/getting worse?a* Yes/No/Uncertain
 11. Was there a delay in ADE diagnosis that contributed to the event persisting/getting worse?b* Yes/No/Uncertain
 12. Was there a failure to act on the result of monitoring or testing?a* Yes/No/Uncertain
 13. Were there errors in the transcription of the culprit drug(s) order?a* Yes/No/Uncertain
 14. Were there any errors in dispensing of the culprit drug(s) order?a* Yes/No/Uncertain
 15. Were there any errors in the administration of the culprit drug(s)?a* Yes/No/Uncertain
 16. Was a superior alternative treatment available (without contraindication) that is less likely to cause an ADE?b* Yes/No/Uncertain
 17. Was there any failure in communication that contributed to the ADE?a* Yes/No/Uncertain
 18. Was there any equipment failure that contributed to the ADE?a* Yes/No/Uncertain
 Automated preventability assessment based on algorithm Definitely/Probably/Not
  1. *Added to the modified Schumock and Thornton algorithm
  2. aIf yes, event is rated as “definitely preventable”
  3. bIf yes, event is rated as “probably preventable”