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Table 1 The resectable pancreatic cancer clinical trial with S0(tc=1)=35%, and S1(tc=1)=50% to attain 90% power at the significance level of 10%

From: Two-stage optimal designs with survival endpoint when the follow-up time is restricted

  Survival endpoint Simon’s design, interim accrual
  The proposed method Belin No Yes
  n 1 n c 1 c E S S 0 E T S L 0 E S S 0 n E S S 0 E T S L 0 n E S S 0 E T S L 0
Minimax 44 73 0.240 -1.281 61.3 3.1    59.3 4.0 72 69.8 3.5
Optimal 41 79 -0.085 -1.279 58.7 2.9 59.1 69 53.2 3.6 81 67.4 3.2
  1. The survival function follows an exponential distribution