Table 1 Characteristics of DRMAs with protocol registration or development and matched controls
Basic information | Total sample (N = 135) | P value | |
|---|---|---|---|
Registered (n = 45) | Matched (n = 90) | ||
Author number [median (IQR)] | 8 (7 to 9) | 5 (3 to 8) | < 0.01 |
> = 6 | 38 (84.44%) | 43 (48.78%) | |
< 6 | 7 (15.56%) | 47 (52.22%) | |
Regions* | |||
Asian | 10 (22.22%) | 20 (22.22%) | Reference |
European | 32 (71.11%) | 44 (48.89%) | ≈1 |
America | 3 (6.67%) | 25 (27.78%) | |
Australia | 0 (0.00%) | 1 (2.22%) | |
Database searched [median (IQR)] | 3 (2 to 7) | 2 (2 to 3) | 0.52 |
> = 2 | 36 (80.00%) | 76 (84.44%) | |
< 2 | 9 (20.00%) | 14 (15.56%) | |
Funding | 0.88 | ||
Yes | 38 (84.44%) | 63 (70.00%) | |
No | 4 (8.89%) | 6 (6.67%) | |
Not reported | 3 (6.67%) | 21 (23.33%) | ─ |
Journal type | 0.60 | ||
General journal | 7 (15.56%) | 11 (12.22%) | |
Specialist journal | 38 (84.44%) | 79 (87.78%) | |
Publish year* | 0.6 | ||
2011–2013 | 18 (40.00%) | 32 (35.56%) | |
2014–2016 | 15 (33.33%) | 38 (42.22%) | |
2017~ | 12 (26.67%) | 20 (22.22%) | |
Use of reporting checklist | |||
Yes | 36 | 56 | 0.02 |
No | 9 | 34 | |
The score of AMSTAR [median (IQR)] | 9 (8 to 11) | 9 (7 to 10) | ─ |
The score of PRISMA [median (IQR)] | 22 (22 to 23) | 22 (21 to 24) | ─ |