Fig. 5

Interval plots of results of the validation and actual measurements. a Tumor burden size per patient at baseline (above) and post-treatment (below). The intervals indicate the 95% central ranges of the simulated burden sizes. The stars indicate the tumor burden sizes re-measured by the second radiologist. b ORR per resampling. The intervals indicate the 95% central ranges of the objective response rates (ORRs) from the simulation. The circles and stars indicate the ORRs measured by the first radiologist and the second radiologist, respectively