Fig. 5

Distribution of simulated hazard ratio (n = 500 subjects) in simulation study II. The scatterplot of estimated hazards ratio for recrudescence and new infection for drug B relative to drug A from 1000 simulation runs. The median and interquartile range is shown. The centre green dot depicts the true hazard ratio which was used to simulate the respective datasets (1, 2.72 or 0.37). RC = recrudescence, NI = New infection. The description of each of the individual scenario is provided in Table 1