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Table 4 Results of MA and data synthesis

From: Methodological steps used by authors of systematic reviews and meta-analyses of clinical trials: a cross-sectional study

Variable

Number (%)

Know pre/post-intervention data and post-intervention data (Yes), n = 364

161 (44.2)

Investigating the efficacy of an intervention, and the pre- and post-intervention (pre/post) values for each group with the correlation value were not available, n = 156

 Used pre/post-difference values for each group

77 (49.4)

 Used post values for each group

40 (25.6)

 Used (pre/post) values for each group and use correlation value

39 (25.0)

If the (pre/post) values for each group are the only data available but the correlation value is not available, what did you do? n = 157

 Request authors of original articles

53 (33.8)

 Use a default correlation value of 0.5 if no response from authors

28 (17.8)

 Analyze several tests with correlation values ranging from 0.1–0.9 if nonresponse from authors

32 (20.4)

 I do not know what is meant by the correlation value

44 (28)

Using raw data (such as mean, SD) or analyzed results (such as p-values) in the MA, n = 382

 Use raw data

221 (57.9)

 Use analyzed result

26 (6.8)

 It is dependent on case by case

135 (35.3)

MA of adjusted or non-adjusted data, n = 372

 Unadjusted data alone

118 (31.7)

 Adjusted data alone

58 (15.6)

 Meta-analyze both ways

163 (43.8)

 Select data that have higher level of nominal significance

9 (2.4)

 I don’t know adjusted and unadjusted data

24 (6.5)

Repeating the same data of placebo in many subgroups when analyzing subgroup based on the concentration of the drug used, n = 350

 Yes

75 (21.4)

 No, because the same population cannot be pooled twice in one MA. So the author should only perform subtotal results.

275 (78.6)

 Ever extracted Pearson correlation for analysis, n = 370

96 (25.9)

 Ever extracted Spearman correlation for analysis, n = 368

71 (19.3)

Dealing with Pearson and Spearman correlation in the MA (combining or separating), n = 190

 Analyze each method separately in two MAs

127 (66.8)

 Use only Pearson method

34 (17.9)

 Combine both in one MA

23 (12.1)

 Use only Spearman method

6 (3.2)

  1. The data is represented by the number and percentage (%). MA; meta-analysis; standard deviation