Fig. 8
From: Sequence symmetry analysis graphic adjustment for prescribing trends
a: The curve-fit adjusted RR for risperidone and frusemide is 1.26, which effectively agrees with the Tsiropoulos adjusted RR of 1.27. The proportion of patients prescribed both medicines is 1.82%. b: The curve fitted difference where counts for after-prescribed frusemide generally exceed those for before-prescribed frusemide is greatest around week 5 and extends to week 37. After that, the counts for after-prescribed frusemide are generally less than those for before-prescribed frusemide. A sufficiently large positive effect denotes an adverse effect, a sufficiently large negative effect denotes a protective effect, and zero is the locus for no effect