Table 2 Static prediction model
From: Dynamic risk prediction for diabetes using biomarker change measurements
| Â | Placebo Hazard Ratio (95% Confidence Interval) | Metformin Hazard Ratio (95% Confidence Interval) |
|---|---|---|
Age | ||
 < 40 | REF | REF |
 40–44 | 1.17 (0.84,1.63) | 1.05 (0.72,1.52) |
 45–49 | 1.07 (0.79,1.45) | 0.93 (0.65,1.34) |
 50–54 | 0.9 (0.64,1.25) | 0.95 (0.67,1.34) |
 55–59 | 0.76 (0.53,1.1) | 0.8 (0.53,1.21) |
 60–64 | 0.91 (0.61,1.36) | 1.07 (0.72,1.6) |
 65+ | 0.98 (0.64,1.49) | 1 (0.66,1.51) |
Gender | ||
 Male | REF | REF |
 Female | 1.04 (0.85,1.28) | 1.14 (0.92,1.42) |
BMI | ||
 < 30 kg/m2 | REF | REF |
 ≥ 30 to < 35 kg/m2 | 0.96 (0.75,1.22) | 0.91 (0.71,1.18) |
 ≥ 35 kg/m2 | 1.28 (1.02,1.62)* | 1 (0.78,1.29) |
Smoking Status | ||
 Yes | 0.93 (0.67,1.3) | 1.33 (0.91,1.94) |
 No | REF | REF |
 Not available | 1.15 (0.82,1.62) | 1.31 (0.92,1.87) |
Race/ethnicity | ||
 White | REF | REF |
 Black | 1.13 (0.89,1.43) | 0.94 (0.73,1.22) |
 Hispanic | 1.31 (1,1.7)* | 0.98 (0.74,1.3) |
 Other | 1.34 (0.89,2.01) | 0.86 (0.5,1.47) |
Fasting plasma glucose (mg/dL) | 1.08 (1.07,1.09)*** | 1.05 (1.04,1.07)*** |
Hemoglobin A1c (%) | 1.52 (1.24,1.87)*** | 1.73 (1.39,2.17)*** |