Fig. 4

Distribution of the successive conclusions and errors, obtained by applying the decision rule to the 5000 simulated trials, at each interim analysis and in overall, for severe intraventricular haemorrhage. The left part of the plot represents the conclusions at each interim analysis. The right part represents the overall count of conclusions among the 11 analyses. The upper part of the plot represents the trials with an Acceptable difference between arms: orange area correspond to trials that conclude that the difference between arms is Acceptable, while it is true; red area correspond to trials that conclude that the difference between arms is Unacceptable, while it is not true (class a misclassifications). The bottom part of the plot represents the trials with an Unacceptable difference between arms: green area correspond to trials that conclude that the difference between arms is Unacceptable, while it is true; blue area correspond to trials that conclude that the difference between arms is Acceptable, while it is not true (class b misclassifications)