Table 3 Description of each of the models used in the analysis and their differences to the gold-standard model 1
Model | Description | Difference from model 1 |
|---|---|---|
1 | − Model for analysis of individual patient data − Estimation of the between-trial variance of the interaction between treatment effect and age − Estimation of the between-trial variance of the treatment effect − Separation of within- from between-trial interaction effects | – |
2 | − Model for analysis of individual patient data − Estimation of the between-trial variance of the interaction between treatment effect and age − Separation of within- from between-trial interaction effects | − No estimation of the between-trial variance of the treatment effect |
3 | − Model for analysis of individual patient data − Estimation of the between-trial variance of the treatment effect − Separation of within- from between-trial interaction effects | − No estimation of the between-trial variance of the interaction between treatment effect and age |
4 | − Model for analysis of individual patient data − Estimation of the between-trial variance of the interaction between treatment effect and age − Estimation of the between-trial variance of the treatment effect − No separation of within- from between-trial interaction effects | − No separation of within- from between-trial interaction effects |
5 | − Model for analysis of individual patient data − Estimation of the between-trial variance of the interaction between treatment effect and age − No separation of within- from between-trial interaction effects | − No estimation of the between-trial variance of the treatment effect − No separation of within- from between-trial interaction effects |
6 | − Model for analysis of individual patient data − Estimation of the between-trial variance of the treatment effect − No separation of within- from between-trial interaction effects | − No estimation of the between-trial variance of the interaction between treatment effect and age − No separation of within- from between-trial interaction effects |
7 | − Model for analysis of aggregate data − Estimation of the between-trial variance of the treatment effect | − Model for analysis of aggregate data − No estimation of the between-trial variance of the interaction between treatment effect and age − No separation of within- from between-trial interaction effects |