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Table 3 Description of each of the models used in the analysis and their differences to the gold-standard model 1

From: A comparison of the statistical performance of different meta-analysis models for the synthesis of subgroup effects from randomized clinical trials

Model Description Difference from model 1
1 − Model for analysis of individual patient data
− Estimation of the between-trial variance of the interaction between treatment effect and age
− Estimation of the between-trial variance of the treatment effect
− Separation of within- from between-trial interaction effects
2 − Model for analysis of individual patient data
− Estimation of the between-trial variance of the interaction between treatment effect and age
− Separation of within- from between-trial interaction effects
− No estimation of the between-trial variance of the treatment effect
3 − Model for analysis of individual patient data
− Estimation of the between-trial variance of the treatment effect
− Separation of within- from between-trial interaction effects
− No estimation of the between-trial variance of the interaction between treatment effect and age
4 − Model for analysis of individual patient data
− Estimation of the between-trial variance of the interaction between treatment effect and age
− Estimation of the between-trial variance of the treatment effect
− No separation of within- from between-trial interaction effects
− No separation of within- from between-trial interaction effects
5 − Model for analysis of individual patient data
− Estimation of the between-trial variance of the interaction between treatment effect and age
− No separation of within- from between-trial interaction effects
− No estimation of the between-trial variance of the treatment effect
− No separation of within- from between-trial interaction effects
6 − Model for analysis of individual patient data
− Estimation of the between-trial variance of the treatment effect
− No separation of within- from between-trial interaction effects
− No estimation of the between-trial variance of the interaction between treatment effect and age
− No separation of within- from between-trial interaction effects
7 − Model for analysis of aggregate data
− Estimation of the between-trial variance of the treatment effect
− Model for analysis of aggregate data
− No estimation of the between-trial variance of the interaction between treatment effect and age
− No separation of within- from between-trial interaction effects