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Table 3 Description of each of the models used in the analysis and their differences to the gold-standard model 1

From: A comparison of the statistical performance of different meta-analysis models for the synthesis of subgroup effects from randomized clinical trials

Model

Description

Difference from model 1

1

− Model for analysis of individual patient data

− Estimation of the between-trial variance of the interaction between treatment effect and age

− Estimation of the between-trial variance of the treatment effect

− Separation of within- from between-trial interaction effects

2

− Model for analysis of individual patient data

− Estimation of the between-trial variance of the interaction between treatment effect and age

− Separation of within- from between-trial interaction effects

− No estimation of the between-trial variance of the treatment effect

3

− Model for analysis of individual patient data

− Estimation of the between-trial variance of the treatment effect

− Separation of within- from between-trial interaction effects

− No estimation of the between-trial variance of the interaction between treatment effect and age

4

− Model for analysis of individual patient data

− Estimation of the between-trial variance of the interaction between treatment effect and age

− Estimation of the between-trial variance of the treatment effect

− No separation of within- from between-trial interaction effects

− No separation of within- from between-trial interaction effects

5

− Model for analysis of individual patient data

− Estimation of the between-trial variance of the interaction between treatment effect and age

− No separation of within- from between-trial interaction effects

− No estimation of the between-trial variance of the treatment effect

− No separation of within- from between-trial interaction effects

6

− Model for analysis of individual patient data

− Estimation of the between-trial variance of the treatment effect

− No separation of within- from between-trial interaction effects

− No estimation of the between-trial variance of the interaction between treatment effect and age

− No separation of within- from between-trial interaction effects

7

− Model for analysis of aggregate data

− Estimation of the between-trial variance of the treatment effect

− Model for analysis of aggregate data

− No estimation of the between-trial variance of the interaction between treatment effect and age

− No separation of within- from between-trial interaction effects