Table 5 Performance measures of various methods for handling 45% missingness in recurrences for individuals treated with artemether-lumefantrine
Full data Kaplan-Meier estimate of day 28 cure (SE) = 0.960 (0.1559) | ||||
|---|---|---|---|---|
| Â | Complete case analysis | MI | IPW | IPW-E |
Mechanism 1 | ||||
 Bias | 0.0159 (0.0165) | -0.0026 (0.0079) | 0.0002 (0.0075) | 0.0039 (0.0097) |
 Relative bias | 1.65 % | -0.27 % | 0.02 % | 0.41 % |
 Model based SE | 0.2152 (0.0007) | 0.2001 (0.0008) | 0.2097 (0.0009) | 0.2536 (0.0014) |
 Empirical SE | 0.2032 (0.0045) | 0.1854 (0.0041) | 0.2015 (0.0045) | 0.2582 (0.0058) |
 Coverage | 13.4 % (1.1) | 94.4 % (0.7) | 95.4 % (0.7) | 85.1 % (1.1) |
 RMSE a | 0.5732 (0.0079) | 0.1914 (0.0014) | 0.2028 (0.0023) | 0.2918 (0.0044) |
Mechanism 2a (Weak scenario) | ||||
 Bias | 0.0163 (0.0173) | -0.0022 (0.0084) | 0.0001 (0.0077) | 0.0039 (0.0104) |
 Relative bias | 1.70 % | -0.23 % | 0.01 % | 0.41 % |
 Model based SE | 0.2176 (0.0008) | 0.2041 (0.0008) | 0.2123 (0.0009) | 0.2594 (0.0017) |
 Empirical SE | 0.2053 (0.0046) | 0.1901 (0.0044) | 0.2028 (0.0046) | 0.268 (0.0062) |
 Coverage | 12.3 % (1.0) | 95.5 % (0.7) | 95.7 % (0.6) | 83.7 % (1.2) |
 RMSE a | 0.5907 (0.0085) | 0.1938 (0.0018) | 0.2039 (0.0024) | 0.3019 (0.0051) |
Mechanism 2b (Strong scenario) | ||||
 Bias | 0.0167 (0.0169) | -0.0026 (0.008) | 0.0001 (0.0076) | 0.004 (0.0102) |
 Relative bias | 1.74 % | -0.27 % | 0.01 % | 0.41 % |
 Model based SE | 0.2200 (0.0008) | 0.2060 (0.0008) | 0.2151 (0.0009) | 0.2659 (0.0016) |
 Empirical SE | 0.2060 (0.0046) | 0.1978 (0.0043) | 0.2051 (0.0045) | 0.2772 (0.006) |
 Coverage | 10.1 % (1.0) | 94.5 % (0.7) | 95.7 % (0.6) | 83.1 % (1.2) |
 RMSE a | 0.6085 (0.0082) | 0.2031 (0.0016) | 0.2063 (0.0023) | 0.3119 (0.0046) |