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Table 3 Case-Mix Risk Adjustment Models for Mortality, mRS and EQ-5D

From: Value-based healthcare in ischemic stroke care: case-mix adjustment models for clinical and patient-reported outcomes

 Model 1*:
Mortality
at 3 months
Model 2*:
mRS score
at 3 months
Model 3*:
EQ-5D index score
at 3 months
(Nagelkerke) R20.440.420.37
AUCa0.870.830.78
VariablesMultivariable OR
(95% CI)
P-valueMultivariable OR (95% CI)P-valueßeta
(SE)
P-value
Age1.07 (1.05–1.09)< 0.0011.04 (1.03–1.05)< 0.001−0.007 (0.001)< 0.001
NIHSS on admission1.17 (1.14–1.20)< 0.0011.17 (1.14–1.19)< 0.001− 0.020 (0.001)< 0.001
Heart failure2.54 (1.30–4.97)0.0073.58 (2.14–5.98)< 0.001− 0.130 (0.042)0.002
Previous stroke  1.74 (1.33–2.27)< 0.001− 0.063 (0.023)0.007
Smoking  1.58 (1.18–2.13)0.003− 0.055 (0.025)0.028
Caregiver at discharge  0.67 (0.51–0.86)0.0020.057 (0.022)0.010
Connective tissue disease  2.07 (0.93–4.61)0.074−0.119 (0.061)0.053
Cancer  1.99 (1.35–2.94)0.001−0.065 (0.042)0.122
CCI1.22 (1.13–1.32)< 0.001  −0.020 (0.007)0.003
Onset-to-door time (per 10 min)1.00 (1.00–1.00)0.123    
Diabetes  2.09 (1.12–3.88)0.020  
Sex
(Ref: Female)
    0.041 (0.020)0.036
SES    −0.019 (0.010)0.053
Nationality
(Ref: Native Dutch)
    −0.074 (0.045)0.097
  1. SES Socio-economic status, derived from neighborhood-based ranking, NIHSS National Institute of Health Stroke Scal, CCI Charlson comorbidity index, R2 R-squared, 95% CI 95% confidence interval, SE Standard error
  2. *The case-mix models was using backward selection with the Akaike information criterion (AIC) as a cut-off for the p-value. The imputed dataset (10 imputations of original data N = 1022) was used for the development of all three case-mix model development
  3. aAUC values were calculated for mortality, dichotomized mRS scores (0–2 vs. 3–6) and dichotomized EQ-5D index scores (< 0.65 vs. ≥ 0.65)